Li, N. & Clevers, H. Coexistence of quiescent and active adult stem cells in mammals. Science 327, 542–545 (2010).
Article CAS PubMed PubMed Central Google Scholar
Cheung, T. H. & Rando, T. A. Molecular regulation of stem cell quiescence. Nat. Rev. Mol. Cell Biol. 14, 329–340 (2013).
Article CAS PubMed Google Scholar
Orford, K. W. & Scadden, D. T. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat. Rev. Genet. 9, 115–128 (2008).
Article CAS PubMed Google Scholar
Ramalho-Santos, M. & Willenbring, H. On the origin of the term ‘stem cell’. Cell Stem Cell 1, 35–38 (2007).
Article CAS PubMed Google Scholar
Barker, N., Bartfeld, S. & Clevers, H. Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell 7, 656–670 (2010).
Article CAS PubMed Google Scholar
Cho, I. J. et al. Mechanisms, hallmarks, and implications of stem cell quiescence. Stem Cell Rep. 12, 1190–1200 (2019).
Clevers, H. & Watt, F. M. Defining adult stem cells by function, not by phenotype. Annu. Rev. Biochem. 87, 1015–1027 (2018).
Article CAS PubMed Google Scholar
Cable, J. et al. Adult stem cells and regenerative medicine — a symposium report. Ann. N. Y. Acad. Sci. 1462, 27–36 (2020).
An, Z. et al. A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors. Nat. Commun. 9, 378 (2018).
Article PubMed PubMed Central Google Scholar
Lewis, E. E. L. et al. A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano 10, 8346–8354 (2016).
Article CAS PubMed Google Scholar
Barriga, F. M. et al. Mex3a marks a slowly dividing subpopulation of Lgr5+ intestinal stem cells. Cell Stem Cell 20, 801–816.e7 (2017).
Article CAS PubMed PubMed Central Google Scholar
Cai, S. et al. A quiescent Bcl11b high stem cell population is required for maintenance of the mammary gland. Cell Stem Cell 20, 247–260.e5 (2017).
Article CAS PubMed Google Scholar
Fu, N. Y. et al. Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive. Nat. Cell Biol. 19, 164–176 (2017).
Article CAS PubMed Google Scholar
Quarta, M. et al. An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy. Nat. Biotechnol. 34, 752–759 (2016).
Article CAS PubMed PubMed Central Google Scholar
Montarras, D. et al. Direct isolation of satellite cells for skeletal muscle regeneration. Science 309, 2064–2067 (2005).
Article CAS PubMed Google Scholar
Marqués-Torrejón, M. Á. et al. LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells. Nat. Commun. 12, 259 (2021).
Sacco, A., Doyonnas, R., Kraft, P., Vitorovic, S. & Blau, H. M. Self-renewal and expansion of single transplanted muscle stem cells. Nature 456, 502–506 (2008).
Article CAS PubMed PubMed Central Google Scholar
Kobayashi, H. et al. Environmental optimization enables maintenance of quiescent hematopoietic stem cells ex vivo. Cell Rep. 28, 145–158.e9 (2019).
Article CAS PubMed Google Scholar
Mourikis, P. et al. A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state. Stem Cells 30, 243–252 (2012).
Article CAS PubMed Google Scholar
Bjornson, C. R. R. et al. Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells 30, 232–242 (2012).
Article CAS PubMed Google Scholar
Engler, A. et al. Notch2 signaling maintains NSC quiescence in the murine ventricular-subventricular zone. Cell Rep. 22, 992–1002 (2018).
Article CAS PubMed Google Scholar
Wang, W. et al. Notch2 blockade enhances hematopoietic stem cell mobilization and homing. Haematologica 102, 1785–1795 (2017).
Article CAS PubMed PubMed Central Google Scholar
Fujimaki, S. et al. Notch1 and Notch2 coordinately regulate stem cell function in the quiescent and activated states of muscle satellite cells. Stem Cells 36, 278–285 (2018).
Article CAS PubMed Google Scholar
Sousa-Victor, P., García-Prat, L. & Muñoz-Cánoves, P. Control of satellite cell function in muscle regeneration and its disruption in ageing. Nat. Rev. Mol. Cell Biol. 23, 204–226 (2022).
Article CAS PubMed Google Scholar
De Micheli, A. J. et al. Single-cell analysis of the muscle stem cell hierarchy identifies heterotypic communication signals involved in skeletal muscle regeneration. Cell Rep. 30, 3583–3595.e5 (2020).
Article PubMed PubMed Central Google Scholar
Llorens-Bobadilla, E. et al. Single-cell transcriptomics reveals a population of dormant neural stem cells that become activated upon brain injury. Cell Stem Cell 17, 329–340 (2015).
Article CAS PubMed Google Scholar
Rodriguez-Fraticelli, A. E. et al. Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis. Nature 583, 585–589 (2020).
Article CAS PubMed PubMed Central Google Scholar
Velten, L. et al. Human haematopoietic stem cell lineage commitment is a continuous process. Nat. Cell Biol. 19, 271–281 (2017).
Article CAS PubMed PubMed Central Google Scholar
Cabezas-Wallscheid, N. et al. Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy. Cell 169, 807–823.e19 (2017).
Article CAS PubMed Google Scholar
Machado, L. et al. Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation. Cell Stem Cell 28, 1125–1135.e7 (2021).
Article CAS PubMed Google Scholar
Joost, S. et al. Single-cell transcriptomics reveals that differentiation and spatial signatures shape epidermal and hair follicle heterogeneity. Cell Syst. 3, 221–237.e9 (2016).
Article CAS PubMed PubMed Central Google Scholar
Zywitza, V., Misios, A., Bunatyan, L., Willnow, T. E. & Rajewsky, N. Single-cell transcriptomics characterizes cell types in the subventricular zone and uncovers molecular defects impairing adult neurogenesis. Cell Rep. 25, 2457–2469.e8 (2018).
Article CAS PubMed Google Scholar
Chua, B. A., Van Der Werf, I., Jamieson, C. & Signer, R. A. J. Post-transcriptional regulation of homeostatic, stressed, and malignant stem cells. Cell Stem Cell 26, 138–159 (2020).
Article CAS PubMed PubMed Central Google Scholar
de Morrée, A. et al. Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence. Proc. Natl Acad. Sci. USA 114, E8996–E9005 (2017).
Article PubMed PubMed Central Google Scholar
Urbán, N. et al. Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. Science 353, 292–295 (2016).
Article PubMed PubMed Central Google Scholar
Ma, X. et al. Msi2 maintains quiescent state of hair follicle stem cells by directly repressing the Hh signaling pathway. J. Invest. Dermatol. 137, 1015–1024 (2017).
Article CAS PubMed PubMed Central Google Scholar
Cabezas-Wallscheid, N. et al. Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Cell Stem Cell 15, 507–522 (2014).
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