van Asch, C. J. et al. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol. 9, 167–176 (2010).

Article  PubMed  Google Scholar 

Krishnamurthi, R. V. et al. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990–2010: findings from the Global Burden of Disease Study 2010. Lancet Glob. Health 1, e259–e281 (2013).

Article  PubMed  PubMed Central  Google Scholar 

GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 20, 795–820 (2021). Provides information on global burden and regional disparities related to ICH.

Article  Google Scholar 

Poon, M. T. C., Fonville, A. F. & Al-Shahi Salman, R. Long-term prognosis after intracerebral haemorrhage: systematic review and meta-analysis. J. Neurol. Neurosurg. Psychiatry 85, 660–667 (2014).

Article  PubMed  Google Scholar 

Moulin, S. et al. Dementia risk after spontaneous intracerebral haemorrhage: a prospective cohort study. Lancet Neurol. 15, 820–829 (2016). Patients with ICH are at high risk of developing post-ICH dementia, which contributes to the poor outcome of these patients.

Article  PubMed  Google Scholar 

Li, L. et al. Risks of recurrent stroke and all serious vascular events after spontaneous intracerebral haemorrhage: pooled analyses of two population-based studies. Lancet Neurol. 20, 437–447 (2021). Reports data from two community-based cohorts on vascular events occurring after ICH. It also identifies a specific subgroup of people with concomitant atrial fibrillation.

Article  PubMed  PubMed Central  Google Scholar 

Krishnamurthi, R. V. et al. Stroke prevalence, mortality and disability-adjusted life years in adults aged 20–64 years in 1990–2013: data from the global burden of disease 2013 study. Neuroepidemiology 45, 190–202 (2015).

Article  PubMed  Google Scholar 

Ariesen, M. J., Claus, S. P., Rinkel, G. J. E. & Algra, A. Risk factors for intracerebral hemorrhage in the general population: a systematic review. Stroke 34, 2060–2065 (2003).

Article  CAS  PubMed  Google Scholar 

Tatlisumak, T., Cucchiara, B., Kuroda, S., Kasner, S. E. & Putaala, J. Nontraumatic intracerebral haemorrhage in young adults. Nat. Rev. Neurol. 14, 237–250 (2018).

Article  PubMed  Google Scholar 

An, S. J., Kim, T. J. & Yoon, B.-W. Epidemiology, risk factors, and clinical features of intracerebral hemorrhage: an update. J. Stroke 19, 3–10 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Kittner, S. J. et al. Ethnic and racial variation in intracerebral hemorrhage risk factors and risk factor burden. JAMA Netw. Open 4, e2121921 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Roquer, J. et al. Sex-related differences in primary intracerebral hemorrhage. Neurology 87, 257–262 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Gokhale, S., Caplan, L. R. & James, M. L. Sex differences in incidence, pathophysiology, and outcome of primary intracerebral hemorrhage. Stroke 46, 886–892 (2015).

Article  PubMed  Google Scholar 

van Beijnum, J. et al. Outcome after spontaneous and arteriovenous malformation-related intracerebral haemorrhage: population-based studies. Brain 132, 537–543 (2009).

Article  PubMed  Google Scholar 

Rannikmäe, K. et al. Reliability of intracerebral hemorrhage classification systems: a systematic review. Int. J. Stroke 11, 626–636 (2016).

Article  PubMed  Google Scholar 

Meretoja, A. et al. SMASH-U: a proposal for etiologic classification of intracerebral hemorrhage. Stroke 43, 2592–2597 (2012).

Article  PubMed  Google Scholar 

Charidimou, A. et al. The cerebral haemorrhage anatomical rating instrument (CHARTS): development and assessment of reliability. J. Neurol. Sci. 372, 178–183 (2017).

Article  PubMed  Google Scholar 

Martí-Fàbregas, J. et al. The H-ATOMIC criteria for the etiologic classification of patients with intracerebral hemorrhage. PLoS ONE 11, e0156992 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Raposo, N. et al. A causal classification system for intracerebral hemorrhage subtypes (CLAS-ICH). Ann. Neurol. 93, 16–28 (2023).

Article  PubMed  Google Scholar 

van Asch, C. J. J. et al. Diagnostic yield and accuracy of CT angiography, MR angiography, and digital subtraction angiography for detection of macrovascular causes of intracerebral haemorrhage: prospective, multicentre cohort study. BMJ 351, h5762 (2015). Describes diagnostic performance of CTA in an ICH population as well as the prevalence of various causes of non-traumatic ICH when investigations are systematically performed.

Article  PubMed  PubMed Central  Google Scholar 

Pantoni, L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 9, 689–701 (2010).

Article  PubMed  Google Scholar 

Rodrigues, M. A. et al. The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. Lancet Neurol. 17, 232–240 (2018). Diagnostic criteria for CAA using CT scan and genetic testing.

Article  PubMed  PubMed Central  Google Scholar 

Sembill, J. A. et al. Simplified Edinburgh CT criteria for identification of lobar intracerebral hemorrhage associated with cerebral amyloid angiopathy. Neurology 98, e1997–e2004 (2022).

CAS  PubMed  Google Scholar 

Flaherty, M. L. et al. Racial variations in location and risk of intracerebral hemorrhage. Stroke 36, 934–937 (2005).

Article  PubMed  Google Scholar 

Charidimou, A. et al. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain 140, 1829–1850 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Viswanathan, A. & Greenberg, S. M. Cerebral amyloid angiopathy in the elderly. Ann. Neurol. 70, 871–880 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charidimou, A., Gang, Q. & Werring, D. J. Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J. Neurol. Neurosurg. Psychiatry 83, 124–137 (2012).

Article  PubMed  Google Scholar 

Rossrussel, R. W. Observations on intracerebral aneurysms. Brain 86, 425–442 (1963).

Article  Google Scholar 

Fischer, U. et al. Acute post-stroke blood pressure relative to premorbid levels in intracerebral haemorrhage versus major ischaemic stroke: a population-based study. Lancet Neurol. 13, 374–384 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Al-Shahi Salman, R. et al. Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data. Lancet Neurol. 17, 885–894 (2018). Provides data on haematoma expansion, the main target of medical treatments of ICH developed to date.

Article  PubMed  PubMed Central  Google Scholar 

Dowlatshahi, D. et al. Defining hematoma expansion in intracerebral hemorrhage: relationship with patient outcomes. Neurology 76, 1238–1244 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greenberg, C. H., Frosch, M. P., Goldstein, J. N., Rosand, J. & Greenberg, S. M. Modeling intracerebral hemorrhage growth and response to anticoagulation. PLoS ONE 7, e48458 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schlunk, F. & Greenberg, S. M. The pathophysiology of intracerebral hemorrhage formation and expansion. Transl Stroke Res. 6, 257–263 (2015).

Article  CAS  PubMed  Google Scholar 

Ironside, N., Chen, C.-J., Ding, D., Mayer, S. A. & Connolly, E. S. J. Perihematomal edema after spontaneous intracerebral hemorrhage. Stroke 50, 1626–1633 (2019).

Article  PubMed  Google Scholar 

Zheng, H., Chen, C., Zhang, J. & Hu, Z. Mechanism and therapy of brain edema after intracerebral hemorrhage. Cerebrovasc. Dis. 42, 155–169 (2016).

Article  PubMed  Google Scholar 

Keep, R. F., Hua, Y. & Xi, G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 11, 720–731 (2012).

Article  CAS  PubMed  Google Scholar 

Aronowski, J. & Zhao, X. Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. Stroke 42, 1781–1786 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Loan, J. J. et al. Secondary injury and inflammation after intracerebral haemorrhage: a systematic review and meta-analysis of molecular markers in patient brain tissue. J. Neurol. Neurosurg. Psychiatry 93, 126–132 (2022).

Article  PubMed  Google Scholar 

Maślińska, D. & Gajewski, M. Some aspects of the inflammatory process. Folia Neuropathol. 36, 199–204 (1998).

PubMed  Google Scholar 

Gong, C., Hoff, J. T. & Keep, R. F. Acute inflammatory reaction following experimental intracerebral hemorrhage in rat. Brain Res. 871, 57–65 (2000).

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