Williams MC, Kwiecinski J, Doris M, McElhinney P, D’Souza MS, Cadet S, et al. Low-attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction: results from the multicenter SCOT-HEART trial (Scottish Computed Tomography of the HEART). Circulation 2020;141:1452‐62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tzolos E, Williams MC, McElhinney P, Lin A, Grodecki K, Flores Tomasino G, et al. Pericoronary adipose tissue attenuation, low-attenuation plaque burden, and 5-year risk of myocardial infarction. Cardiovasc Imaging 2022;15:1078‐88.

Google Scholar 

Oikonomou EK, Marwan M, Desai MY, Mancio J, Alashi A, Centeno EH, et al. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet 2018;392:929‐39.

Article  PubMed  PubMed Central  Google Scholar 

van Diemen PA, Bom MJ, Driessen RS, Schumacher SP, Everaars H, de Winter RW, et al. Prognostic value of RCA pericoronary adipose tissue CT-attenuation beyond high-risk plaques, plaque volume, and ischemia. Cardiovascular Imaging 2021;14:1598‐610.

PubMed  Google Scholar 

Kwiecinski J, Dey D, Cadet S, Lee SE, Otaki Y, Huynh PT, et al. Peri-coronary adipose tissue density is associated with 18F-sodium fluoride coronary uptake in stable patients with high-risk plaques. JACC Cardiovasc Imaging 2019;12:2000‐10.

Article  PubMed  PubMed Central  Google Scholar 

Lu MT, Park J, Ghemigian K, Mayrhofer T, Puchner SB, Liu T, et al. Epicardial and paracardial adipose tissue volume and attenuation–Association with high-risk coronary plaque on computed tomographic angiography in the ROMICAT II trial. Atherosclerosis 2016;251:47‐54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goeller M, Tamarappoo BK, Kwan AC, Cadet S, Commandeur F, Razipour A, et al. Relationship between changes in pericoronary adipose tissue attenuation and coronary plaque burden quantified from coronary computed tomography angiography. Eur Heart J Cardiovasc Imaging 2019;20:636‐43.

Article  PubMed  PubMed Central  Google Scholar 

Kuronuma K, van Diemen PA, Han D, Lin A, Grodecki K, Kwiecinski J, et al. Relationship between impaired myocardial blood flow by positron emission tomography and low-attenuation plaque burden and pericoronary adipose tissue attenuation from coronary computed tomography: From the prospective PACIFIC trial. J Nucl Cardiol 2023;16:1‐2.

Google Scholar 

Tzolos E, McElhinney P, Williams MC, Cadet S, Dweck MR, Berman DS, et al. Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography. J Cardiovasc Comput Tomogr 2021;15:81‐4.

Article  PubMed  Google Scholar 

Dey D, Diaz Zamudio M, Schuhbaeck A, Juarez Orozco LE, Otaki Y, Gransar H, et al. Relationship between quantitative adverse plaque features from coronary computed tomography angiography and downstream impaired myocardial flow reserve by 13N-ammonia positron emission tomography: a pilot study. Circ Cardiovasc Imaging 2015;8:e003255.

Article  PubMed  PubMed Central  Google Scholar 

Driessen RS, Stuijfzand WJ, Raijmakers PG, Danad I, Min JK, Leipsic JA, et al. Effect of plaque burden and morphology on myocardial blood flow and fractional flow reserve. J Am Coll Cardiol 2018;71:499‐509.

Article  PubMed  Google Scholar 

Nappi C, Ponsiglione A, Acampa W, Gaudieri V, Zampella E, Assante R, et al. Relationship between epicardial adipose tissue and coronary vascular function in patients with suspected coronary artery disease and normal myocardial perfusion imaging. Eur Heart J Cardiovasc Imaging 2019;20:1379‐87.

Article  PubMed  Google Scholar 

Nomura CH, Assuncao-Jr AN, Guimaraes PO, Liberato G, Morais TC, Fahel MG, et al. Association between perivascular inflammation and downstream myocardial perfusion in patients with suspected coronary artery disease. Eur Heart J Cardiovasc Imaging 2020;21:599‐605.

Article  PubMed  Google Scholar 

Qi XY, Qu SL, Xiong WH, Rom O, Chang L, Jiang ZS. Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword. Cardiovasc Diabetol 2018;17:1‐20.

Article  Google Scholar 

Jenke A, Wilk S, Poller W, Eriksson U, Valaperti A, Rauch BH, et al. Adiponectin protects against Toll-like receptor 4-mediated cardiac inflammation and injury. Cardiovasc Res 2013;99:422‐31.

Article  CAS  PubMed  Google Scholar 

Konior A, Schramm A, Czesnikiewicz-Guzik M, Guzik TJ. NADPH oxidases in vascular pathology. Antioxid Redox Signal 2014;20:2794‐814.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verhagen SN, Visseren FL. Perivascular adipose tissue as a cause of atherosclerosis. Atherosclerosis 2011;214:3‐10.

Article  CAS  PubMed  Google Scholar 

Lin A, Dey D, Wong DT, Nerlekar N. Perivascular adipose tissue and coronary atherosclerosis: from biology to imaging phenotyping. Curr Atheroscler Rep 2019;21:1‐2.

Article  CAS  Google Scholar 

Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, et al. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. Eur Heart J 2019;40:3529‐43.

Article  PubMed  PubMed Central  Google Scholar 

Dou H, Feher A, Davila AC, Romero MJ, Patel VS, Kamath VM, et al. Role of adipose tissue endothelial ADAM17 in age-related coronary microvascular dysfunction. Arterioscler Thromb Vasc Biol 2017;37:1180‐93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003;108:2460‐6.

Article  PubMed  Google Scholar 

Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 2009;119:1661‐70.

Article  CAS  PubMed  Google Scholar 

Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa JI, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79‐83.

Article  CAS  PubMed  Google Scholar 

Iacobellis G, Pistilli D, Gucciardo M, Leonetti F, Miraldi F, Brancaccio G, et al. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine 2005;29:251‐5.

CAS  PubMed  Google Scholar 

Hirata Y, Tabata M, Kurobe H, Motoki T, Akaike M, Nishio C, et al. Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. J Am Coll Cardiol 2011;58:248‐55.

Article  CAS  PubMed  Google Scholar 

Wen D, Xu Z, An R, Ren J, Jia Y, Li J, et al. Predicting haemodynamic significance of coronary stenosis with radiomics-based pericoronary adipose tissue characteristics. Clin Radiol 2022;77:e154‐61.

Article  CAS  PubMed  Google Scholar 

Lin A, Kolossváry M, Yuvaraj J, Cadet S, McElhinney PA, Jiang C, et al. Myocardial infarction associates with a distinct pericoronary adipose tissue radiomic phenotype: a prospective case-control study. Cardiovasc Imaging 2020;13:2371‐83.

CAS  Google Scholar