Parham DM, Barr FG. Classification of rhabdomyosarcoma and its molecular basis. Adv Anat Pathol. 2013;20:387–97. https://doi.org/10.1097/PAP.0b013e3182a92d0d.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rudzinski ER, Anderson JR, Hawkins DS, Skapek SX, Parham DM, Teot LA. The World Health Organization classification of skeletal muscle tumors in pediatric rhabdomyosarcoma: a report from the Children’s Oncology Group. Arch Pathol Lab Med. 2015;139:1281–7. https://doi.org/10.5858/arpa.2014-0475-OA.

Article  PubMed  PubMed Central  Google Scholar 

Sun X, Guo W, Shen JK, Mankin HJ, Hornicek FJ, Duan Z. Rhabdomyosarcoma: advances in molecular and cellular biology. Sarcoma. 2015;2015:232010. https://doi.org/10.1155/2015/232010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raney B, Huh W, Hawkins D, Hayes-Jordan A, Million L, Rodeberg D, Teot L, Anderson J, Soft Tissue Sarcoma Committee of the Children’s Oncology Group A, CA. Outcome of patients with localized orbital sarcoma who relapsed following treatment on Intergroup Rhabdomyosarcoma Study Group (IRSG) Protocols-III and -IV, 1984–1997: a report from the Children’s Oncology Group. Pediatr Blood Cancer. 2013;60:371–6. https://doi.org/10.1002/pbc.24289.

Article  PubMed  Google Scholar 

Lei W-H, Wu W-F, Zhen J-Y, Li Y-H, Li J, Xin J. Alveolar paratesticular rhabdomyosarcoma mimicing epididymitis: case report and literature review. Medicine. 2018;97:e11164. https://doi.org/10.1097/md.0000000000011164.

Article  PubMed  PubMed Central  Google Scholar 

Armeanu-Ebinger S, Griessinger CM, Herrmann D, Fuchs J, Kneilling M, Pichler BJ, Seitz G. PET/MR imaging and optical imaging of metastatic rhabdomyosarcoma in mice. J Nucl Med Offl Publ Soc Nucl Med. 2014;55:1545–51. https://doi.org/10.2967/jnumed.114.138578.

Article  CAS  Google Scholar 

Moritake H, Kamimura S, Akiyoshi K, Nagatoshi Y, Chuman H, Okamura J. Prognostic significance of elevated lactate dehydrogenase and creatine kinase in patients with rhabdomyosarcoma. Med Pediatr Oncol. 2003;40:187–8. https://doi.org/10.1002/mpo.10115.

Article  PubMed  Google Scholar 

Al-Husseinawi E, Bui MM, Ahmed AA. Grb2-associated binding protein-1 as a biomarker in bone and soft tissue sarcomas. Pathology. 2019;51:610–4. https://doi.org/10.1016/j.pathol.2019.05.003.

Article  CAS  PubMed  Google Scholar 

Singh M, Leasure JM, Chronowski C, Geier B, Bondra K, Duan W, Hensley LA, Villalona-Calero M, Li N, Vergis AM, Kurmasheva RT, Shen C, Woods G, Sebastian N, Fabian D, Kaplon R, Hammond S, Palanichamy K, Chakravarti A, Houghton PJ. FANCD2 is a potential therapeutic target and biomarker in alveolar rhabdomyosarcoma harboring the PAX3-FOXO1 fusion gene. Clin Cancer Res Offl J Am Assoc Cancer Res. 2014;20:3884–95. https://doi.org/10.1158/1078-0432.Ccr-13-0556.

Article  CAS  Google Scholar 

Sun C, Liu C, Li S, Li H, Wang Y, Xie Y, Li B, Cui X, Chen Y, Zhang W, Li F. Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma. Int J Clin Exp Pathol. 2014;7:1606–15.

PubMed  PubMed Central  Google Scholar 

Wang Y, Sun C, Jiang J, Xie Y, Li B, Cui X, Chen Y, Liu C, Li F. GLI1 expression is an important prognostic factor that contributes to the poor prognosis of rhabdomyosarcoma. Histol Histopathol. 2016;31:329–37. https://doi.org/10.14670/hh-11-682.

Article  CAS  PubMed  Google Scholar 

Poli E, Zin A, Cattelan M, Tombolan L, Zanetti I, Scagnellato A, Bonvini P, Bisogno G. Prognostic value of circulating IGFBP2 and related autoantibodies in children with metastatic rhabdomyosarcomas. Diagnostics (Basel, Switzerland). 2020. https://doi.org/10.3390/diagnostics10020115.

Article  PubMed  PubMed Central  Google Scholar 

Rammal G, Fahs A, Kobeissy F, Mechref Y, Zhao J, Zhu R, Diab-Assaf M, Saab R, Ghayad SE. Proteomic profiling of rhabdomyosarcoma-derived exosomes yield insights into their functional role in paracrine signaling. J Proteome Res. 2019;18:3567–79. https://doi.org/10.1021/acs.jproteome.9b00157.

Article  CAS  PubMed  Google Scholar 

Stewart E, McEvoy J, Wang H, Chen X, Honnell V, Ocarz M, Gordon B, Dapper J, Blankenship K, Yang Y, Li Y, Shaw TI, Cho J-H, Wang X, Xu B, Gupta P, Fan Y, Liu Y, Rusch M, Griffiths L, Jeon J, Freeman BB, Clay MR, Pappo A, Easton J, Shurtleff S, Shelat A, Zhou X, Boggs K, Mulder H, Yergeau D, Bahrami A, Mardis ER, Wilson RK, Zhang J, Peng J, Downing JR, Dyer MA, Project SJCsRHWUPCG. Identification of therapeutic targets in rhabdomyosarcoma through integrated genomic, epigenomic, and proteomic analyses. Cancer Cell. 2018;34:411-426.e419. https://doi.org/10.1016/j.ccell.2018.07.012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Casado-Vela J, Pulgar TGd, Cebrián A, Alvarez-Ayerza N, Lacal JC. Human urine proteomics: building a list of human urine cancer biomarkers. Expert Rev Proteom. 2011;8:347–60. https://doi.org/10.1586/epr.11.26.

Article  CAS  Google Scholar 

Zhao M, Li M, Yang Y, Guo Z, Sun Y, Shao C, Li M, Sun W, Gao Y. A comprehensive analysis and annotation of human normal urinary proteome. Sci Rep. 2017;7:3024. https://doi.org/10.1038/s41598-017-03226-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Group CCsC, Association CA-C, Hematology TSGo, the Society of Pediatrics CMA, The Subspecialty Group of Oncology tSoPS & Association CM. Recommendations for the diagnosis and treatment of rhabdomyosarcoma in Chinese children and adolescents(CCCG-RMS-2016). Chin J Pediatr 2017; 55: 724-728. https://doi.org/10.3760/cma.j.issn.0578-1310.2017.10.002

Wiśniewski JR, Zougman A, Nagaraj N, Mann M. Universal sample preparation method for proteome analysis. Nat Methods. 2009;6:359–62. https://doi.org/10.1038/nmeth.1322.

Article  CAS  PubMed  Google Scholar 

Winter SV, Karayel O, Strauss MT, Padmanabhan S, Surface M, Merchant K, Alcalay RN, Mann M. Urinary proteome profiling for stratifying patients with familial Parkinson’s disease. EMBO Mol Med. 2021;13:e13257. https://doi.org/10.15252/emmm.202013257.

Article  CAS  Google Scholar 

Ramadan F, Fahs A, Ghayad SE, Saab R. Signaling pathways in Rhabdomyosarcoma invasion and metastasis. Cancer Metastasis Rev. 2020;39:287–301. https://doi.org/10.1007/s10555-020-09860-3.

Article  PubMed  Google Scholar 

Singh S, Vinson C, Gurley CM, Nolen GT, Beggs ML, Nagarajan R, Wagner EF, Parham DM, Peterson CA. Impaired Wnt signaling in embryonal rhabdomyosarcoma cells from p53/c-fos double mutant mice. Am J Pathol. 2010;177:2055–66. https://doi.org/10.2353/ajpath.2010.091195.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen EY, DeRan MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM, Lobbardi RM, Brockmann J, Keller C, Wu X, Langenau DM. Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci USA. 2014;111:5349–54. https://doi.org/10.1073/pnas.1317731111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, Ambrogio L, Auclair D, Wang J, Song YK, Tolman C, Hurd L, Liao H, Zhang S, Bogen D, Brohl AS, Sindiri S, Catchpoole D, Badgett T, Getz G, Mora J, Anderson JR, Skapek SX, Barr FG, Meyerson M, Hawkins DS, Khan J. Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov. 2014;4:216–31. https://doi.org/10.1158/2159-8290.Cd-13-0639.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moreira DC, Macy ME, Cost CR, Greffe BS, Garrington TP. Central nervous system involvement of rhabdomyosarcoma: a single institution experience. J Pediatr Hematol Oncol. 2019;41:152–4. https://doi.org/10.1097/mph.0000000000001166.

Article  PubMed  PubMed Central  Google Scholar 

De B, Kinnaman MD, Wexler LH, Kramer K, Wolden SL. Central nervous system relapse of rhabdomyosarcoma. Pediatr Blood Cancer. 2018. https://doi.org/10.1002/pbc.26710.

Article  PubMed  Google Scholar 

Vora M, Ansari J, Shanti RM, Veillon D, Cotelingam J, Coppola D, Shackelford RE. Increased nicotinamide phosphoribosyltransferase in rhabdomyosarcomas and leiomyosarcomas compared to skeletal and smooth muscle tissue. Anticancer Res. 2016;36:503–7.

CAS  PubMed  PubMed Central  Google Scholar 

Tombolan L, Poli E, Martini P, Zin A, Millino C, Pacchioni B, Celegato B, Bisogno G, Romualdi C, Rosolen A, Lanfranchi G. Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. BMC Cancer. 2016;16:886. https://doi.org/10.1186/s12885-016-2936-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai Y, Li J, Fang B, Edwards A, Zhang G, Bui M, Eschrich S, Altiok S, Koomen J, Haura EB. Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors. Can Res. 2012;72:2501–11. https://doi.org/10.1158/0008-5472.Can-11-3015.

Article  CAS  Google Scholar 

Vergé C, Bouchatal A, Chirat F, Guérardel Y, Maftah A, Petit J-M. Involvement of ST6Gal I-mediated α2,6 sialylation in myoblast proliferation and differentiation. FEBS Open Bio. 2020;10:56–69. https://doi.org/10.1002/2211-5463.12745.

Article  CAS  PubMed  Google Scholar 

Walsh S, Metter EJ, Ferrucci L, Roth SM. Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol (Bethesda, MD: 1985). 2007;102:2142–8. https://doi.org/10.1152/japplphysiol.01322.2006.

Article  CAS  Google Scholar 

Calero-Cuenca FJ, Osorio DS, Carvalho-Marques S, Sridhara SC, Oliveira LM, Jiao Y, Diaz J, Janota CS, Cadot B, Gomes ER. Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration. Curr Biol CB. 2021;31:1521-1530.e1528. https://doi.org/10.1016/j.cub.2021.01.007.

Article  CAS  PubMed  Google Scholar 

Meo AD, Batruch I, Brown MD, Yang C, Finelli A, Jewett MA, Diamandis EP, Yousef GM. Searching for prognostic biomarkers for small renal masses in the urinary proteome. Int J Cancer. 2020;146:2315–25. https://doi.org/10.1002/ijc.32650.

Article  CAS  PubMed  Google Scholar 

Mukherjee S, Biswas D, Gadre R, Jain P, Syed N, Stylianou J, Zeng Q, Mahadevan A, Epari S, Shetty P, Moiyadi A, Ball GR, Srivastava S. Comprehending meningioma signaling cascades using multipronged proteomics approaches & targeted validation of potential markers. Front Oncol. 2020;10:1600. https://doi.org/10.3389/fonc.2020.01600.

Article