Inhibition of Cdc37 Ameliorates Arthritis in Collagen-Induced Arthritis Rats by Inhibiting Synoviocyte Proliferation and Migration Through the ERK Pathway

Niu, Y., Q. Dong, and R. Li. 2017. Matrine regulates Th1/Th2 cytokine responses in rheumatoid arthritis by attenuating the NF-kappaB signaling. Cell Biology International 41: 611–621.

Article  CAS  PubMed  Google Scholar 

Agere, S.A., N. Akhtar, J.M. Watson, and S. Ahmed. 2017. RANTES/CCL5 induces collagen degradation by activating MMP-1 and MMP-13 expression in human rheumatoid arthritis synovial fibroblasts. Frontiers in Immunology 8: 1341.

Article  PubMed  PubMed Central  Google Scholar 

Feldmann, M., F.M. Brennan, and R.N. Maini. 1996. Rheumatoid arthritis. Cell 85: 307–310.

Article  CAS  PubMed  Google Scholar 

Li, C.H., L.L. Xu, J.X. Zhao, L. Sun, Z.Q. Yao, X.L. Deng, R. Liu, L. Yang, R. Xing, and X.Y. Liu. 2016. CXCL16 upregulates RANKL expression in rheumatoid arthritis synovial fibroblasts through the JAK2/STAT3 and p38/MAPK signaling pathway. Inflammation Research 65: 193–202.

Article  CAS  PubMed  Google Scholar 

Liu, Y., Y.F. Pan, Y.Q. Xue, L.K. Fang, X.H. Guo, X. Guo, M. Liu, B.Y. Mo, M.R. Yang, F. Liu, et al. 2018. uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/Akt signaling pathway in patients with rheumatoid arthritis. Cellular & Molecular Immunology 15: 171–181.

Article  CAS  Google Scholar 

Huber, L.C., O. Distler, I. Tarner, R.E. Gay, S. Gay, and T. Pap. 2006. Synovial fibroblasts: Key players in rheumatoid arthritis. Rheumatology (Oxford) 45: 669–675.

Article  CAS  PubMed  Google Scholar 

Okamoto, H., K. Shidara, D. Hoshi, and N. Kamatani. 2007. Anti-arthritis effects of vitamin K(2) (menaquinone-4)–a new potential therapeutic strategy for rheumatoid arthritis. FEBS Journal 274: 4588–4594.

Article  CAS  PubMed  Google Scholar 

Lee, H.S., S.J. Woo, H.W. Koh, S.O. Ka, L. Zhou, K.Y. Jang, H.S. Lim, H.O. Kim, S.I. Lee, and B.H. Park. 2014. Regulation of apoptosis and inflammatory responses by insulin-like growth factor binding protein 3 in fibroblast-like synoviocytes and experimental animal models of rheumatoid arthritis. Arthritis & Rhematology 66: 863–873.

Article  CAS  Google Scholar 

Bartok, B., and G.S. Firestein. 2010. Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis. Immunological Reviews 233: 233–255.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nam, E.J., J.H. Kang, S. Sung, K.H. Sa, K.H. Kim, J.S. Seo, J.H. Kim, S.W. Han, I.S. Kim, and Y.M. Kang. 2013. A matrix metalloproteinase 1-cleavable composite peptide derived from transforming growth factor beta-inducible gene h3 potently inhibits collagen-induced arthritis. Arthritis and Rheumatism 65: 1753–1763.

Article  CAS  PubMed  Google Scholar 

Verba, K.A., R.Y. Wang, A. Arakawa, Y. Liu, M. Shirouzu, S. Yokoyama, and D.A. Agard. 2016. Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase. Science 352: 1542–1547.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verba, K.A., and D.A. Agard. 2017. How Hsp90 and Cdc37 lubricate kinase molecular switches. Trends in Biochemical Sciences 42: 799–811.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith, J.R., P.A. Clarke, E. de Billy, and P. Workman. 2009. Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. Oncogene 28: 157–169.

Article  CAS  PubMed  Google Scholar 

Gray, P.J., Jr., M.A. Stevenson, and S.K. Calderwood. 2007. Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells. Cancer Research 67: 11942–11950.

Article  CAS  PubMed  Google Scholar 

El Hamidieh, A., N. Grammatikakis, and E. Patsavoudi. 2012. Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion. PLoS ONE 7: e42722.

Article  PubMed  PubMed Central  Google Scholar 

Wang, Z., W. Wei, C.K. Sun, M.S. Chua, and S. So. 2015. Suppressing the CDC37 cochaperone in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth. Liver International 35: 1403–1415.

Article  PubMed  Google Scholar 

Schwarze, S.R., V.X. Fu, and D.F. Jarrard. 2003. Cdc37 enhances proliferation and is necessary for normal human prostate epithelial cell survival. Cancer Research 63: 4614–4619.

CAS  PubMed  Google Scholar 

Ota, A., and Y. Wang. 2012. Cdc37/Hsp90 protein-mediated regulation of IRE1alpha protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells. Journal of Biological Chemistry 287: 6266–6274.

Article  CAS  PubMed  Google Scholar 

Liu, Y., S. Wang, D. Ding, Z. Yu, W. Sun, and Y. Wang. 2018. Up-regulation of Cdc37 contributes to Schwann cell proliferation and migration after sciatic nerve crush. Neurochemical Research 43: 1182–1190.

Article  CAS  PubMed  Google Scholar 

Zhang, H.G., Y. Wang, J.F. Xie, X. Liang, D. Liu, P. Yang, H.C. Hsu, R.B. Ray, and J.D. Mountz. 2001. Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Arthritis and Rheumatism 44: 1555–1567.

Article  CAS  PubMed  Google Scholar 

King, D., D. Yeomanson, and H.E. Bryant. 2015. PI3King the lock: Targeting the PI3K/Akt/mTOR pathway as a novel therapeutic strategy in neuroblastoma. Journal of Pediatric Hematology/oncology 37: 245–251.

Article  CAS  PubMed  Google Scholar 

Chen, B.C., and W.W. Lin. 2001. PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: Enhancement by P2Y receptor-mediated CaMK activation. British Journal of Pharmacology 134: 1055–1065.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsing, C.H., M.C. Lin, P.C. Choi, W.C. Huang, J.I. Kai, C.C. Tsai, Y.L. Cheng, C.Y. Hsieh, C.Y. Wang, Y.P. Chang, et al. 2011. Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKbeta/NF-kappaB signaling. PLoS ONE 6: e17598.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, D.W., X.T. Wang, B.C. Mu, D.Q. Dou, and T.G. Kang. 2021. Effects of hydroxysafflor yellow A on rats with collagen-induced arthritis. Biochemical and Biophysical Research Communications 570: 26–34.

Article  CAS  PubMed  Google Scholar 

Yu, X., J. Zhou, F. Zhao, X. Liu, Y. Mao, L. Diao, C. Wen, and M. Liu. 2021. Tomatidine suppresses the destructive behaviors of fibroblast-like synoviocytes and ameliorates type II collagen-induced arthritis in rats. Frontiers in Pharmacology 12: 670707.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, C., A. Pan, X. Chen, J. Tu, X. Xia, and L. Sun. 2019. MiR-5571-3p and miR-135b-5p, derived from analyses of microRNA profile sequencing, correlate with increased disease risk and activity of rheumatoid arthritis. Clinical Rheumatology 38: 1753–1765.

Article  PubMed  Google Scholar 

Fan, W., Z. Xu, S. Liang, S. Zuo, C. Bian, X. Gao, Y. Qin, and J. Wu. 2021. MLL3 inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes and promotes secretion of inflammatory factors by activating CCL2 and the NF-kappaB pathway. Inflammation 44: 1803–1814.

Article  CAS  PubMed  Google Scholar 

Li, G., Y. Liu, F. Meng, Z. Xia, X. Wu, Y. Fang, C. Zhang, Y. Zhang, and D. Liu. 2019. LncRNA MEG3 inhibits rheumatoid arthritis through miR-141 and inactivation of AKT/mTOR signalling pathway. Journal of Cellular and Molecular Medicine 23: 7116–7120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Philippe, L., G. Alsaleh, A. Pichot, E. Ostermann, G. Zuber, B. Frisch, J. Sibilia, S. Pfeffer, S. Bahram, D. Wachsmann, and P. Georgel. 2013. MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes. Annals of the Rheumatic Diseases 72: 1071–1079.

Article  CAS  PubMed  Google Scholar 

Zhang, T., H. Li, J. Shi, S. Li, M. Li, L. Zhang, L. Zheng, D. Zheng, F. Tang, X. Zhang, et al. 2016. p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis. Arthritis Research & Therapy 18: 271.

Article  Google Scholar 

Liu, F.L., L.H. Lin, H.K. Sytwu, and D.M. Chang. 2010. GDF-5 is suppressed by IL-1beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes. Experimental and Molecular Pathology 88: 163–170.

Article  CAS  PubMed  Google Scholar 

Qiu, H., S. Sun, X. Ma, C. Cui, G. Chen, Z. Liu, H. Li, and M. Liu M. 2018. Jatrorrhizine hydrochloride suppresses proliferation, migration, and secretion of synoviocytes in vitro and ameliorates rat models of rheumatoid arthritis in vivo. Internation Journal of Molecular Sciences 19.

Lee, J.W., J. Lee, S.H. Um, and E.Y. Moon. 2017. Synovial cell death is regulated by TNF-alpha-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1alpha. Cell Death & Disease 8: e2727.

Article  CAS  Google Scholar 

Huang, C.C., C.H. Chiou, S.C. Liu, S.L. Hu, C.M. Su, C.H. Tsai, and C.H. Tang. 2019. Melatonin attenuates TNF-alpha and IL-1beta expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis. Journal of Pineal Research 66: e12560.

Article  PubMed  Google Scholar 

Pinto, L.G., J. Talbot, R.S. Peres, R.F. Franca, S.H. Ferreira, B. Ryffel, J.C. Aves-Filho, F. Figueiredo, T.M. Cunha, and F.Q. Cunha. 2015. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1beta production. Arthritis Research & Therapy 17: 235.

Article  Google Scholar 

Sparks, J.A. 2019. Rheumatoid Arthritis. Annals of Intern Medici

留言 (0)

沒有登入
gif