Recycling Tenofovir in Second-line Antiretroviral Treatment With Dolutegravir: Outcomes and Viral Load Trajectories to 72 weeks

aMedecins Sans Frontiers, Cape Town, South Africa;

bHealth Systems Collaborative, Oxford Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford;

cDivision of Public Health Medicine, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa;

dDepartment of Medicine, University of Cape Town, Cape Town, South Africa;

eWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa;

fDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa;

gUniversity of Liverpool, Department of Pharmacology, Liverpool, United Kingdom; and

hStellenbosch University, Division of Medical Virology, Cape Town, South Africa and National Health Laboratory Service, Tygerberg Business Unit, Cape Town, South Africa.

Correspondence to: Graeme Meintjes, Department of Medicine, University of Cape Town, Cape Town, South Africa (e-mail: [email protected]).

This work was supported by the Wellcome Trust [212265/Z/18/Z] (Ga.M.) and the Médecins Sans Frontières Khayelitsha project. The Wellcome Centre for Infectious Diseases Research in Africa is supported with core funding from the Wellcome Trust [203135/Z/16/Z]. Gr.M. was supported by the Wellcome Trust [214321/Z/18/Z], and the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation (NRF) of South Africa [Grant No 64787]. Ga.M. received fees from ViiV Healthcare for a consultancy in 2018. T.C. was a contractor for Gilead Sciences during the time of this analysis.

The authors have no conflicts of interest to disclose.

Presented at the Southern African HIV Clinicians Society 24th International Workshop on HIV Drug Resistance and Treatment Strategies (September 2021) and the fifthSouthern African HIV Clinicians Society Conference (October 2021).

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