A DNA Methylation-based Epigenetic Signature for the Identification of Lymph Node Metastasis in T1 Colorectal Cancer

*Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Monrovia, CA

‡Department of Biological Chemistry, Division of Computational Biomedicine, School of Medicine, University of California, Irvine, CA

§Shandong Engineering & Technology Research Center for Tumor Marker Detection, Jinan, China

∥Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory, Jinan, China

†Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

¶Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan

#Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

**City of Hope Comprehensive Cancer Center, Duarte, CA

Y.Z. and F.P. contributed equally.

Supported by CA184792, CA187956, CA227602, CA072851, and CA202797 grants from the National Cancer Institute, National Institutes of Health.

Presented as a poster at Digestive Disease Week (DDW) in May 2021.

The authors report no conflicts of interest.

[email protected], [email protected]

Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website, www.annalsofsurgery.com.

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