Pancreas and Islet Transplantation: Comparative Outcome Analysis of a Single-centre Cohort Over 20-years

*Department of Surgery

§Clinical Islet Transplant Program

∥Department of Medicine, Division of Endocrinology and Metabolism

#Histocompatibility Laboratory, Department of Laboratory Medicine and Pathology, University of Alberta

**Alberta Diabetes Institute, Edmonton, Canada

†Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

¶Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico

‡CHRISTUS-LatAm Hub - Excellence and Innovation Center, Monterrey, Mexico

D.B. and A.M.J.S. shared co-senior authorship

B.A.M.-G.: contributed to study design, data retrieval and data verification, data analysis and interpretation, figure conception, design and construction, and writing of the report. K.V.: contributed to data retrieval, data verification, data interpretation, and writing of the report. J.H.: contributed to data retrieval, data verification, data interpretation and writing of the report. A.L.: contributed to patient follow-up, data retrieval, and writing of the report. K.D. contributed to organ procurement, patient care and follow-up, and writing of the report. B.A.: contributed to organ procurement, patient care and follow-up, and writing of the report. D.O.G.: contributed to islet isolation, data retrieval and writing of the report. T.K.: contributed to islet isolation, data retrieval, data verification, and writing of the report. O.Y.B.-C.: contributed to data analysis and interpretation, figure design and construction, and writing of the report. D.G., A.H., and P.M.C.: contributed to providing data on HLA typing and writing of the report. P.A.S.: contributed to patient follow-up, data retrieval, data interpretation and writing of the report. D.B.: contributed to organ procurement, study design, patient care and follow-up, data retrieval, data verification, data interpretation and writing of the report. A.M.J.S.: contributed to organ procurement, study design, patient care and follow-up, data retrieval, data verification, data interpretation and writing of the report. B.A.M.-G., K.V., .J.H, T.K., D.B., and A.M.J.S.: had access to raw data. D.B. and A.M.J.S.: had final responsibility for the decision to submit this manuscript for publication (Supplemental Digital Content 1, https://links.lww.com/SLA/E392).

All data are available upon reasonable request.

Peter Senior is the Charles A Allard Chair in Diabetes Research. AMJS is supported through a Canada Research Chair (Tier 1) in Regenerative Medicine and Transplant Surgery, and through grant support from the Juvenile Diabetes Research Foundation, Diabetes Canada, The Canadian Donation and Transplant Research Project, the Diabetes Research Institute Foundation of Canada (DRIFCan), the Alberta Diabetes Foundation, and the Canadian Stem Cell Network. Braulio A. Marfil-Garza is supported by the Patronato del Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), the Fundacion para la Salud y la Educacion Dr. Salvador Zubirán (FunSaEd), and the CHRISTUS Excellence and Innovation Center.

B.A.M.-G. is a co-inventor for a patent on TNFRSF25-mediated treatments of immune diseases and disorders (PCT/US2020/053085). P.A.S. serves in an independent data monitoring committee overseeing safety of stem cell-derived β-cells for T1D (Vertex Pharmaceuticals), as Board Chair for Diabetes Canada, and as a co-lead for Diabetes Action Canada’s innovations in T1D goal group. A.M.J.S. has received grants or contracts from the Juvenile Diabetes Research Foundation, Canadian Stem Cell Network, Diabetes Research Foundation in Canada, ViaCyte Inc., and the National Institutes of Diabetes and Digestive and Kidney Diseases. A.M.J.S. serves as a consultant to Protokinetix Inc., ViaCyte Inc., Hemostemix Inc., Diagon Inc., and Aspect Biosystems Inc. A.M.J.S. is a co-inventor for a patent on TNFRSF25-mediated treatments of immune diseases and disorders (PCT/US2020/053085) and for a Cellular Transplant Site- Device-less technology (US 14/863541, CA.286512). The remaining authors report no conflicts of interest.

[email protected]

Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website, www.annalsofsurgery.com.

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