Y.P. Chen, A.T.C. Chan, Q.T. Le, P. Blanchard, Y. Sun, J. Ma, Nasopharyngeal carcinoma. Lancet 394, 64–80 (2019)

Article  PubMed  Google Scholar 

K.C.W. Wong, E.P. Hui, K.W. Lo, W.K.J. Lam, D. Johnson, L. Li, Q. Tao, K.C.A. Chan, K.F. To, A.D. King, B.B.Y. Ma, A.T.C. Chan, Nasopharyngeal carcinoma: an evolving paradigm. Nat. Rev. Clin. Oncol. 18, 679–695 (2021)

Article  CAS  PubMed  Google Scholar 

R. Zheng, S. Zhang, H. Zeng, S. Wang, K. Sun, R. Chen, L. Li, W. Wei, J. He, Cancer incidence and mortality in China, 2016. J. Natl. Cancer Cent. 2, 1–9 (2022)

Article  Google Scholar 

W. Chen, R. Zheng, P.D. Baade, S. Zhang, H. Zeng, F. Bray, A. Jemal, X.Q. Yu, J. He, Cancer statistics in China, 2015. CA Cancer J. Clin. 66, 115–132 (2016)

Article  PubMed  Google Scholar 

T. Yoshizaki, S. Kondo, K. Endo, Y. Nakanishi, M. Aga, E. Kobayashi, N. Hirai, H. Sugimoto, M. Hatano, T. Ueno, K. Ishikawa, N. Wakisaka, Modulation of the tumor microenvironment by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. Cancer Sci. 109, 272–278 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Zhang, K.D. MacIsaac, T. Zhou, P.Y. Huang, C. Xin, J.R. Dobson, K. Yu, D.Y. Chiang, Y. Fan, M. Pelletier, Y. Wang, S. Jaeger, V. Krishnamurthy Radhakrishnan, L. JeBailey, P. Skewes-Cox, J. Zhang, W. Fang, Y. Huang, H. Zhao, Y. Zhao, E. Li, B. Peng, A. Huang, G. Dranoff, P.S. Hammerman, J. Engelman, H. Bitter, Y.X. Zeng, Y. Yao, Genomic analysis of nasopharyngeal carcinoma reveals TME-based subtypes. Mol. Cancer Res. 15, 1722–1732 (2017)

Article  CAS  PubMed  Google Scholar 

S. Jin, R. Li, M.Y. Chen, C. Yu, L.Q. Tang, Y.M. Liu, J.P. Li, Y.N. Liu, Y.L. Luo, Y. Zhao, Y. Zhang, T.L. Xia, S.X. Liu, Q. Liu, G.N. Wang, R. You, J.Y. Peng, J. Li, F. Han, J. Wang, Q.Y. Chen, L. Zhang, H.Q. Mai, B.E. Gewurz, B. Zhao, L.S. Young, Q. Zhong, F. Bai, M.S. Zeng, Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma. Cell Res. 30, 950–965 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S.C. Liu, N.M. Tsang, P.J. Lee, Y.H. Sui, C.H. Huang, T.T. Liu, Epstein-barr virus induces adipocyte dedifferentiation to modulate the tumor microenvironment. Cancer Res. 81, 3283–3294 (2021)

Article  CAS  PubMed  Google Scholar 

X. Liu, Y. Deng, Y. Huang, J. Ye, S. Xie, Q. He, Y. Chen, Y. Lin, R. Liang, J. Wei, Y. Li, J. Zhang, Nasopharyngeal carcinoma progression: Accumulating genomic insta vcxzzbility and persistent epstein-barr virus infection. Curr Oncol. 29, 6035–6052 (2022)

Article  PubMed  PubMed Central  Google Scholar 

N.A. Giraldo, R. Sanchez-Salas, J.D. Peske, Y. Vano, E. Becht, F. Petitprez, P. Validire, A. Ingels, X. Cathelineau, W.H. Fridman, C. Sautès-Fridman, The clinical role of the TME in solid cancer. Br. J. Cancer. 120, 45–53 (2019)

Article  PubMed  Google Scholar 

Y. Huang, M. Kanada, J. Ye, Y. Deng, Q. He, Z. Lei, Y. Chen, Y. Li, P. Qin, J. Zhang, J. Wei, Exosome-mediated remodeling of the tumor microenvironment: From local to distant intercellular communication. Cancer Lett. 543, 215796 (2022)

Article  CAS  PubMed  Google Scholar 

D.G. Meckes Jr., K.H. Shair, A.R. Marquitz, C.P. Kung, R.H. Edwards, N. Raab-Traub, Human tumor virus utilizes exosomes for intercellular communication. Proc. Natl. Acad. Sci. U. S. A. 107, 20370–20375 (2010)

Article  PubMed  PubMed Central  Google Scholar 

A.A. Benders, W. Tang, J.M. Middeldorp, A.E. Greijer, L.B. Thorne, W.K. Funkhouser, W.K. Rathmell, M.L. Gulley, Epstein-Barr virus latent membrane protein 1 is not associated with vessel density nor with hypoxia inducible factor 1 alpha expression in nasopharyngeal carcinoma tissue. Head Neck Pathol. 3, 276–282 (2009)

Article  PubMed  PubMed Central  Google Scholar 

A. Kieser, K.R. Sterz, The Latent Membrane Protein 1 (LMP1). Curr. Top. Microbiol. Immunol. 391, 119–149 (2015)

CAS  PubMed  Google Scholar 

C. Keryer-Bibens, C. Pioche-Durieu, C. Villemant, S. Souquère, N. Nishi, M. Hirashima, J. Middeldorp, P. Busson, Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9. BMC Cancer 6, 283 (2006)

Article  PubMed  PubMed Central  Google Scholar 

J. Wei, J. Zhang, Y. Si, M. Kanada, Z. Zhang, S. Terakawa, H. Watanabe, Blockage of LMP1-modulated store-operated Ca2+ entry reduces metastatic potential in nasopharyngeal carcinoma cell. Cancer Lett. 360, 234–244 (2015)

Article  CAS  PubMed  Google Scholar 

J. Ye, J. Huang, Q. He, W. Zhao, X. Zhou, Z. Zhang, Y. Li, J. Wei, J. Zhang, Blockage of store-operated Ca2+ entry antagonizes Epstein-Barr virus-promoted angiogenesis by inhibiting Ca2+ signaling-regulated VEGF production in nasopharyngeal carcinoma. Cancer Manag. Res. 10, 1115–1124 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Ye, J. Wei, Y. Luo, Y. Deng, T. Que, X. Zhang, F. Liu, J. Zhang, X. Luo, Epstein-barr virus promotes tumor angiogenesis by activating STIM1-dependent Ca2+ signaling in nasopharyngeal carcinoma. Pathogens 10, 1275 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S.W. Messenger, S.S. Woo, Z. Sun, T.F.J. Martin, A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4. J. Cell Biol. 217, 2877–2890 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Savina, C.M. Fader, M.T. Damiani, M.I. Colombo, Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner. Traffic 6, 131–143 (2005)

Article  CAS  PubMed  Google Scholar 

A. Savina, M. Furlán, M. Vidal, M.I. Colombo, Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J. Biol. Chem. 278, 20083–20090 (2003)

Article  CAS  PubMed  Google Scholar 

Y. Chen, R. Koshy, E. Guirado, A. George, STIM1 a calcium sensor promotes the assembly of an ECM that contains Extracellular vesicles and factors that modulate mineralization. Acta Biomater. 120, 224–239 (2021)

Article  CAS  PubMed  Google Scholar 

S.Y. Chan, K.W. Choy, S.W. Tsao, Q. Tao, T. Tang, G.T. Chung, K.W. Lo, Authentication of nasopharyngeal carcinoma tumor lines. Int. J. Cancer. 122, 2169–2171 (2008)

Article  CAS  PubMed  Google Scholar 

M.J. Strong, M. Baddoo, A. Nanbo, M. Xu, A. Puetter, Z. Lin, Comprehensive high-throughput RNA sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes. J. Virol. 88, 10696–10704 (2014)

Article  PubMed  PubMed Central  Google Scholar 

J. Wei, J. Ye, Y. Luo, J. Weng, Q. He, F. Liu, M. Li, Y. Lin, Y. Li, Z. Zhang, S. Qu, J. Zhang, EB virus promotes metastatic potential by boosting STIM1-dependent Ca2+ signaling in nasopharyngeal carcinoma cells. Cancer Lett. 478, 122–132 (2020)

Article  CAS  PubMed  Google Scholar 

X. Xiao, X. Zhou, H. Ming, J. Zhang, G. Huang, Z. Zhang, P. Li, Chick chorioallantoic membrane assay: A 3D animal model for study of human nasopharyngeal carcinoma. PLoS ONE 10, e0130935 (2015)

Article  PubMed  PubMed Central  Google Scholar 

J. Wang, Q. Jiang, O.D. Faleti, C.M. Tsang, M. Zhao, G. Wu, S.W. Tsao, M. Fu, Y. Chen, T. Ding, T. Chong, Y. Long, X. Yang, Y. Zhang, Y. Cai, H. Li, M. Peng, X. Lyu, X. Li, Exosomal delivery of antagomiRs targeting viral and cellular microRNAs synergistically inhibits cancer angiogenesis. Mol. Ther. Nucleic Acids. 22, 153–165 (2020)

Article  PubMed  PubMed Central  Google Scholar 

A.K. Lo, C.W. Dawson, H.L. Lung, K.L. Wong, L.S. Young, The role of EBV-encoded LMP1 in the NPC tumor microenvironment: From function to therapy. Front. Oncol. 11, 640207 (2021)

Article  PubMed  PubMed Central  Google Scholar 

J. Zhao, C. Guo, F. Xiong, J. Yu, J. Ge, H. Wang, Q. Liao, Y. Zhou, Q. Gong, B. Xiang, M. Zhou, X. Li, G. Li, W. Xiong, J. Fang, Z. Zeng, Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma. Cancer Lett. 477, 131–143 (2020)

Article  CAS  PubMed  Google Scholar 

Y. Liu, S. He, X.L. Wang, W. Peng, Q.Y. Chen, D.M. Chi, J.R. Chen, B.W. Han, G.W. Lin, Y.Q. Li, Q.Y. Wang, R.J. Peng, P.P. Wei, X. Guo, B. Li, X. Xia, H.Q. Mai, X.D. Hu, Z. Zhang, Y.X. Zeng, J.X. Bei, Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution. Nat. Commun. 12, 741 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Wei, Y. Deng, J. Ye, Y. Luo, J. Weng, Q. He, F. Liu, M. Li, R. Liang, Y. Lin, Y. Li, J. Zhang, J. Yang, S. Qu, Store-operated Ca2+ entry as a key oncogenic Ca2+ signaling driving tumor invasion-metastasis cascade and its translational potential. Cancer Lett. 516, 64–72 (2021)

Article  CAS  PubMed  Google Scholar 

Z. Wang, F. Luo, L. Li, L. Yang, D. Hu, X. Ma, Z. Lu, L. Sun, Y. Cao, STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling. Eur. J. Cancer. 46, 2996–3006 (2010)

Article  CAS  PubMed  Google Scholar 

N. Wakisaka, S. Murono, T. Yoshizaki, M. Furukawa, J.S. Pagano, Epstein-barr virus latent membrane protein 1 induces and causes release of fibroblast growth factor-2. Cancer Res. 62, 6337–6344 (2002)

CAS  PubMed