Beger RD, Dunn W, Schmidt MA, Gross SS, Kirwan JA, Cascante M, Brennan L, Wishart DS, Oresic M, Hankemeier T, Broadhurst DI, Lane AN, Suhre K, Kastenmüller G, Sumner SJ, Thiele I, Fiehn O, Kaddurah-Daouk R, for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative (2016) Metabolomics enables precision medicine: “a white paper, community perspective.” Metabolomics 12(10):149. https://doi.org/10.1007/s11306-016-1094-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bertocchi A, Carloni S, Ravenda PS, Bertalot G, Spadoni I, Lo Cascio A, Gandini S, Lizier M, Braga D, Asnicar F, Segata N, Klaver C, Brescia P, Rossi E, Anselmo A, Guglietta S, Maroli A, Spaggiari P, Tarazona N, Cervantes A, Rescigno M (2021) Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver. Cancer Cell 39(5):708-724.e11. https://doi.org/10.1016/j.ccell.2021.03.004

Article  CAS  PubMed  Google Scholar 

Borst J, Ahrends T, Bąbała N, Melief C, Kastenmüller W (2018) CD4+ T cell help in cancer immunology and immunotherapy. Nat Rev Immunol 18(10):635–647. https://doi.org/10.1038/s41577-018-0044-0

Article  CAS  PubMed  Google Scholar 

Chandrashekar DS, Bashel B, Balasubramanya S, Creighton CJ, Ponce-Rodriguez I, Chakravarthi B, Varambally S (2017) UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia 19(8):649–658. https://doi.org/10.1016/j.neo.2017.05.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong Y, Ma WM, Shi ZD, Zhang ZG, Zhou JH, Li Y, Zhang SQ, Pang K, Li BB, Zhang WD, Fan T, Zhu GY, Xue L, Li R, Liu Y, Hao L, Han CH (2021) Role of NRP1 in Bladder Cancer Pathogenesis and Progression. Frontiers in oncology 11: 685980https://doi.org/10.3389/fonc.2021.685980

Article  PubMed  PubMed Central  Google Scholar 

Elgueta R, Tse D, Deharvengt SJ, Luciano MR, Carriere C, Noelle RJ, Stan RV (2016) Endothelial plasmalemma vesicle-associated protein regulates the homeostasis of splenic immature B cells and B-1 B cells. J Immunol Baltimore Md 1950 197(10):3970–3981. https://doi.org/10.4049/jimmunol.1501859

Article  CAS  Google Scholar 

Fardini Y, Wang X, Témoin S, Nithianantham S, Lee D, Shoham M, Han YW (2011) Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity. Mol Microbiol 82(6):1468–1480. https://doi.org/10.1111/j.1365-2958.2011.07905.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fei Y, Wang Y, Pang Y, Wang W, Zhu D, Xie M, Lan S, Wang Z (2020) Xylooligosaccharide modulates gut microbiota and alleviates colonic inflammation caused by high fat diet induced obesity. Front Physiol 10:1601. https://doi.org/10.3389/fphys.2019.01601

Article  PubMed  PubMed Central  Google Scholar 

Guo L, Zhang H, Hou Y, Wei T, Liu J (2016) Plasmalemma vesicle-associated protein: a crucial component of vascular homeostasis. Exp Ther Med 12(3):1639–1644. https://doi.org/10.3892/etm.2016.3557

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsieh YY, Tung SY, Pan HY, Yen CW, Xu HW, Lin YJ, Deng YF, Hsu WT, Wu CS, Li C (2018) Increased abundance of clostridium and fusobacterium in gastric microbiota of patients with gastric cancer in Taiwan. Sci Rep 8(1):158. https://doi.org/10.1038/s41598-017-18596-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu K, Wang S, Wang Z, Li L, Huang Z, Yu W, Chen Z, Wu QF (2019) Clinicopathological risk factors for gastric cancer: a retrospective cohort study in China. BMJ Open 9(9):e030639. https://doi.org/10.1136/bmjopen-2019-030639

Article  PubMed  PubMed Central  Google Scholar 

Iwahori K (2020) Cytotoxic CD8+ lymphocytes in the tumor microenvironment. Adv Exp Med Biol 1224:53–62. https://doi.org/10.1007/978-3-030-35723-8_4

Article  CAS  PubMed  Google Scholar 

Jiang Z, Zhou C, Cheng L, Yan B, Chen K, Chen X, Zong L, Lei J, Duan W, Xu Q, Li X, Wang Z, Ma Q, Ma J (2018) Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions. J Exp Clin Cancer Res 37(1):69. https://doi.org/10.1186/s13046-018-0740-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, El-Omar EM, Brenner D, Fuchs CS, Meyerson M, Garrett WS (2013) Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 14(2):207–215. https://doi.org/10.1016/j.chom.2013.07.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lánczky A, Nagy Á, Bottai G, Munkácsy G, Szabó A, Santarpia L, Győrffy B (2016) miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients. Breast Cancer Res Treat 160(3):439–446. https://doi.org/10.1007/s10549-016-4013-7

Article  CAS  PubMed  Google Scholar 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B, Liu XS (2017) TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Can Res 77(21):e108–e110. https://doi.org/10.1158/0008-5472.CAN-17-0307

Article  CAS  Google Scholar 

Ma SC, Li Q, Peng JY, Zhouwen JL, Diao JF, Niu JX, Wang X, Guan XD, Jia W, Jiang WG (2017) Claudin-5 regulates blood-brain barrier permeability bymodifying brain microvascular endothelial cell proliferation, migration, and adhesion toprevent lung cancer metastasis. CNS neuroscience & therapeutics 23(12):947–960. https://doi.org/10.1111/cns.12764

Article  CAS  Google Scholar 

Mostafavi S, Ray D, Warde-Farley D, Grouios C, Morris Q (2008) GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function. Genome Biol 9(Suppl 1):S4. https://doi.org/10.1186/gb-2008-9-s1-s4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT, Rotter-Maskowitz A, Weiser R, Mallel G, Gigi E, Meltser A, Douglas GM, Kamer I, Gopalakrishnan V, Dadosh T, Levin-Zaidman S, Avnet S, Atlan T, Cooper ZA, Arora R, Straussman R (2020) The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 368(6494):973–980. https://doi.org/10.1126/science.aay9189

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rubinstein MR, Wang X, Liu W, Hao Y, Cai G, Han YW (2013) Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe 14(2):195–206. https://doi.org/10.1016/j.chom.2013.07.012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spadoni I, Pietrelli A, Pesole G, Rescigno M (2016) Gene expression profile of endothelial cells during perturbation of the gut vascular barrier. Gut Microbes 7(6):540–548. https://doi.org/10.1080/19490976.2016.1239681

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stan RV, Tse D, Deharvengt SJ, Smits NC, Xu Y, Luciano MR, McGarry CL, Buitendijk M, Nemani KV, Elgueta R, Kobayashi T, Shipman SL, Moodie KL, Daghlian CP, Ernst PA, Lee HK, Suriawinata AA, Schned AR, Longnecker DS, Fiering SN, Carrière C (2012) The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition. Dev Cell 23(6):1203–1218. https://doi.org/10.1016/j.devcel.2012.11.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Strickland LA, Jubb AM, Hongo JA, Zhong F, Burwick J, Fu L, Frantz GD, Koeppen H (2005) Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF). J Pathol 206(4):466–475. https://doi.org/10.1002/path.1805

Article  CAS  PubMed  Google Scholar 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, Jensen LJ, von Mering C (2017) The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res 45(D1):D362–D368. https://doi.org/10.1093/nar/gkw937

Article  CAS  PubMed  Google Scholar 

Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z (2017) GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res 45(W1):W98–W102. https://doi.org/10.1093/nar/gkx247

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tu CF, Wu MY, Lin YC, Kannagi R, Yang RB (2017) FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation. Breast Cancer Res 19(1):111. https://doi.org/10.1186/s13058-017-0904-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H (2016) Gastric cancer. Lancet (london, England) 388(10060):2654–2664. https://doi.org/10.1016/S0140-6736(16)30354-3

Article  CAS  PubMed  Google Scholar 

Vinasco K, Mitchell HM, Kaakoush NO, Castaño-Rodríguez N (2019) Microbial carcinogenesis: Lactic acid bacteria in gastric cancer. Biochimica Et Biophysica Acta Rev Cancer 1872(2):188309. https://doi.org/10.1016/j.bbcan.2019.07.004

Article  CAS  Google Scholar 

Wang YH, Cheng TY, Chen TY, Chang KM, Chuang VP, Kao KJ (2014) Plasmalemmal vesicle associated protein (PLVAP) as a therapeutic target for treatment of hepatocellular carcinoma. BMC Cancer 14:815. https://doi.org/10.1186/1471-2407-14-815

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Zhou J, Xin Y, Geng C, Tian Z, Yu X, Dong Q (2016) Bacterial overgrowth and diversification of microbiota in gastric cancer. Eur J Gastroenterol Hepatol 28(3):261–266. https://doi.org/10.1097/MEG.0000000000000542

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Yu H, Xie X, Deng T, Ye L, Wu L, Ding X, Yang Z, Zhu Q, Li J, Zheng Y, Yu Z, Chen G (2021) Plasmalemma vesicle-associated protein promotes angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway. Oncogene 40(25):4324–4337. https://doi.org/10.1038/s41388-021-01844-z