TIMP-2 as a predictive biomarker in 5-Fu-resistant colorectal cancer

Ahmed N, Escalona R, Leung D, Chan E, Kannourakis G (2018) Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells. Semin Cancer Biol 53:265–281. https://doi.org/10.1016/j.semcancer.2018.10.002

Article  CAS  PubMed  Google Scholar 

Apte SS, Parks WC (2015) Metalloproteinases: a parade of functions in matrix biology and an outlook for the future. Matrix Biol 44–46:1–6. https://doi.org/10.1016/j.matbio.2015.04.005

Article  CAS  PubMed  Google Scholar 

Bjornland K, Lehne G, Johansen HT, Fodstad O, Rugstad HE, Aasen AO, Ree AH (1998) Human hepatoma cells rich in P-glycoprotein display enhanced in vitro invasive properties compared to P-glycoprotein-poor hepatoma cells. Oncol Res 10:255–262

CAS  PubMed  Google Scholar 

Blondy S, David V, Verdier M, Mathonnet M, Perraud A, Christou N (2020) 5-Fluorouracil resistance mechanisms in colorectal cancer: from classical pathways to promising processes. Cancer Sci 111:3142–3154. https://doi.org/10.1111/cas.14532

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blondy S, Talbot H, Saada S, Christou N, Battu S, Pannequin J, Jauberteau MO, Lalloué F, Verdier M, Mathonnet M et al (2021) Overexpression of sortilin is associated with 5-FU resistance and poor prognosis in colorectal cancer. J Cell Mol Med 25:47–60. https://doi.org/10.1111/jcmm.15752

Article  CAS  PubMed  Google Scholar 

Cabrero-de Las Heras S, Martínez-Balibrea E (2018) CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer. World J Gastroenterol 24:4738–4749. https://doi.org/10.3748/wjg.v24.i42.4738

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chirco R, Liu XW, Jung KK, Kim HR (2006) Novel functions of TIMPs in cell signaling. Cancer Metastasis Rev 25:99–113. https://doi.org/10.1007/s10555-006-7893-x

Article  CAS  PubMed  Google Scholar 

Das V, Kalita J, Pal M (2017) Predictive and prognostic biomarkers in colorectal cancer: a systematic review of recent advances and challenges. Biomed Pharmacother 87:8–19. https://doi.org/10.1016/j.biopha.2016.12.064

Article  CAS  PubMed  Google Scholar 

Du C, Huang D, Peng Y, Yao Y, Zhao Y, Yang Y, Wang H, Cao L, Zhu WG, Gu J (2017) 5-Fluorouracil targets histone acetyltransferases p300/CBP in the treatment of colorectal cancer. Cancer Lett 400:183–193. https://doi.org/10.1016/j.canlet.2017.04.033

Article  CAS  PubMed  Google Scholar 

Escalona RM, Chan E, Kannourakis G, Findlay JK, Ahmed N (2018) The many facets of metzincins and their endogenous inhibitors: perspectives on ovarian cancer progression. Int J Mol Sci. https://doi.org/10.3390/ijms19020450

Article  PubMed  PubMed Central  Google Scholar 

Gentner B, Wein A, Croner RS, Zeittraeger I, Wirtz RM, Roedel F, Dimmler A, Dorlaque L, Hohenberger W, Hahn EG et al (2009) Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases. Anticancer Res 29:67–74

CAS  PubMed  Google Scholar 

Groblewska M, Mroczko B, Gryko M, Pryczynicz A, Guzinska-Ustymowicz K, Kedra B, Kemona A, Szmitkowski M (2014) Serum levels and tissue expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinases 2 (TIMP-2) in colorectal cancer patients. Tumour Biol 35:3793–3802. https://doi.org/10.1007/s13277-013-1502-8

Article  CAS  PubMed  Google Scholar 

Lawrence W Jr, Terz JJ, Horsley S 3rd, Donaldson M, Lovett WL, Brown PW, Ruffner BW, Regelson W (1975) Chemotherapy as an adjuvant to surgery for colorectal cancer. Ann Surg 181:616–623. https://doi.org/10.1097/00000658-197505000-00016

Article  PubMed  PubMed Central  Google Scholar 

Liu T, Wang X, Hu W, Fang Z, Jin Y, Fang X, Miao QR (2019) Epigenetically raise PCAF increases the resistance of colorectal cancer to 5-fluorouracil. Neoplasia 21:557–570. https://doi.org/10.1016/j.neo.2019.03.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marjaneh RM, Khazaei M, Ferns GA, Avan A, Aghaee-Bakhtiari SH (2019) The role of microRNAs in 5-FU resistance of colorectal cancer: possible mechanisms. J Cell Physiol 234:2306–2316. https://doi.org/10.1002/jcp.27221

Article  CAS  PubMed  Google Scholar 

Na D, Chae J, Cho SY, Kang W, Lee A, Min S, Kang J, Kim MJ, Choi J, Lee W et al (2021) Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts. Nat Commun 12:4840. https://doi.org/10.1038/s41467-021-25122-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nishimoto S, Nishida E (2006) MAPK signalling: ERK5 versus ERK1/2. EMBO Rep 7:782–786. https://doi.org/10.1038/sj.embor.7400755

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park KS, Kim SJ, Kim KH, Kim JC (2011) Clinical characteristics of TIMP2, MMP2, and MMP9 gene polymorphisms in colorectal cancer. J Gastroenterol Hepatol 26:391–397. https://doi.org/10.1111/j.1440-1746.2010.06504.x

Article  CAS  PubMed  Google Scholar 

Peeney D, Jensen SM, Castro NP, Kumar S, Noonan S, Handler C, Kuznetsov A, Shih J, Tran AD, Salomon DS et al (2020) TIMP-2 suppresses tumor growth and metastasis in murine model of triple-negative breast cancer. Carcinogenesis 41:313–325. https://doi.org/10.1093/carcin/bgz172

Article  CAS  PubMed  Google Scholar 

Propper DJ, Balkwill FR (2022) Harnessing cytokines and chemokines for cancer therapy. Nat Rev Clin Oncol 19:237–253. https://doi.org/10.1038/s41571-021-00588-9

Article  CAS  PubMed  Google Scholar 

Shen Q, Lee ES, Pitts RL, Wu MH, Yuan SY (2010) Tissue inhibitor of metalloproteinase-2 regulates matrix metalloproteinase-2-mediated endothelial barrier dysfunction and breast cancer cell transmigration through lung microvascular endothelial cells. Mol Cancer Res 8:939–951. https://doi.org/10.1158/1541-7786.Mcr-09-0523

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A (2021) Cancer Statistics 2021. Cancer J Clin 71:7–33. https://doi.org/10.3322/caac.21654

Article  Google Scholar 

Tang YA, Chen YF, Bao Y, Mahara S, Yatim S, Oguz G, Lee PL, Feng M, Cai Y, Tan EY et al (2018) Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer. Proc Natl Acad Sci USA 115:E5990-e5999. https://doi.org/10.1073/pnas.1801348115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tavakoli F, Jahanban-Esfahlan R, Seidi K, Jabbari M, Behzadi R, Pilehvar-Soltanahmadi Y, Zarghami N (2018) Effects of nano-encapsulated curcumin-chrysin on telomerase, MMPs and TIMPs gene expression in mouse B16F10 melanoma tumour model. Artif Cells Nanomed Biotechnol 46:75–86. https://doi.org/10.1080/21691401.2018.1452021

Article  CAS  PubMed  Google Scholar 

Ushigome M, Shimada H, Miura Y, Yoshida K, Kaneko T, Koda T, Nagashima Y, Suzuki T, Kagami S, Funahashi K (2020) Changing pattern of tumor markers in recurrent colorectal cancer patients before surgery to recurrence: serum p53 antibodies, CA19-9 and CEA. Int J Clin Oncol 25:622–632. https://doi.org/10.1007/s10147-019-01597-6

Article  CAS  PubMed  Google Scholar 

Waleh NS, Murphy BJ, Zaveri NT (2010) Increase in tissue inhibitor of metalloproteinase-2 (TIMP-2) levels and inhibition of MMP-2 activity in a metastatic breast cancer cell line by an anti-invasive small molecule SR13179. Cancer Lett 289:111–118. https://doi.org/10.1016/j.canlet.2009.08.006

Article  CAS  PubMed  Google Scholar 

Wang D, Yang L, Yu W, Wu Q, Lian J, Li F, Liu S, Li A, He Z, Liu J et al (2019) Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling. J Immunother Cancer 7:215. https://doi.org/10.1186/s40425-019-0701-2

Article  PubMed  PubMed Central  Google Scholar 

Wasserman I, Lee LH, Ogino S, Marco MR, Wu C, Chen X, Datta J, Sadot E, Szeglin B, Guillem JG et al (2019) SMAD4 loss in colorectal cancer patients correlates with recurrence, loss of immune infiltrate, and chemoresistance. Clin Cancer Res 25:1948–1956. https://doi.org/10.1158/1078-0432.Ccr-18-1726

Article  CAS  PubMed  Google Scholar 

Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A et al (2019) Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during Anti-EGFR treatment in colorectal cancer. Cancer Cell 36:35-50.e39. https://doi.org/10.1016/j.ccell.2019.05.013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu CY, Wu MS, Chen YJ, Chen CJ, Chen HP, Shun CT, Chen GH, Huang SP, Lin JT (2007) Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer. Eur J Cancer 43:799–808. https://doi.org/10.1016/j.ejca.2006.10.022

Article  CAS  PubMed  Google Scholar 

Yin Y, Yao S, Hu Y, Feng Y, Li M, Bian Z, Zhang J, Qin Y, Qi X, Zhou L et al (2017) The immune-microenvironment confers chemoresistance of colorectal cancer through macrophage-derived IL6. Clin Cancer Res 23:7375–7387. https://doi.org/10.1158/1078-0432.Ccr-17-1283

Article  CAS  PubMed  Google Scholar 

Zhang Q, Liu RX, Chan KW, Hu J, Zhang J, Wei L, Tan H, Yang X, Liu H (2019) Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells. J Exp Clin Cancer Res 38:320. https://doi.org/10.1186/s13046-019-1314-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang G, Luo X, Zhang W, Chen E, Xu J, Wang F, Cao G, Ju Z, Jin D, Huang X et al (2020) CXCL-13 regulates resistance to 5-fluorouracil in colorectal cancer. Cancer Res Treat 52:622–633. https://doi.org/10.4143/crt.2019.593

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