Equine osteoarthritis modifies fatty acid signatures in synovial fluid and its extracellular vesicles

Mustonen A-M, Nieminen P. Fatty acids and oxylipins in osteoarthritis and rheumatoid arthritis—a complex field with significant potential for future treatments. Curr Rheumatol Rep. 2021;23:41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu B, Driban JB, Xu C, Lapane KL, McAlindon TE, Eaton CB. Dietary fat intake and radiographic progression of knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Care Res. 2017;69:368–75.

Article  CAS  Google Scholar 

Alissa EM, Alzughaibi LS, Marzouki ZM. Dietary intake of fatty acids and antioxidants in relation to radiographic knee osteoarthritis: results from a case–control study. J Hum Nutr Diet. 2020;33:431–8.

Article  CAS  PubMed  Google Scholar 

Krok-Schoen JL, Brasky TM, Hunt RP, Rohan TE, Baker TA, Li W, et al. Dietary long-chain omega-3 fatty acid intake and arthritis risk in the Women's Health Initiative. J Acad Nutr Diet. 2018;118:2057–69.

Article  PubMed  PubMed Central  Google Scholar 

Thomas S, Browne H, Mobasheri A, Rayman MP. What is the evidence for a role for diet and nutrition in osteoarthritis? Rheumatology. 2018;57(Suppl. 4):iv61–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manhart DR, Scott BD, Gibbs PG, Coverdale JA, Eller EM, Honnas CM, et al. Markers of inflammation in arthritic horses fed omega-3 fatty acids. Prof Anim Sci. 2009;25:155–60.

Article  Google Scholar 

Ross-Jones TN, McIlwraith CW, Kisiday JD, Hess TM, Hansen DK, Black J. Influence of an n-3 long-chain polyunsaturated fatty acid-enriched diet on experimentally induced synovitis in horses. J Anim Physiol Anim Nutr. 2016;100:565–77.

Article  CAS  Google Scholar 

McCoy AM. Animal models of osteoarthritis: comparisons and key considerations. Vet Pathol. 2015;52:803–18.

Article  CAS  PubMed  Google Scholar 

Ross-Jones T, Hess T, Rexford J, Ahrens N, Engle T, Hansen DK. Effects of omega-3 long chain polyunsaturated fatty acid supplementation on equine synovial fluid fatty acid composition and prostaglandin E2. J Equine Vet Sci. 2014;34:779–83.

Article  Google Scholar 

Caron JP, Gandy JC, Brown JL, Sordillo LM. Omega-3 fatty acids and docosahexaenoic acid oxymetabolites modulate the inflammatory response of equine recombinant interleukin1β-stimulated equine synoviocytes. Prostaglandins Other Lipid Mediat. 2019;142:1–8.

Article  CAS  PubMed  Google Scholar 

Mustonen A-M, Nieminen P. Extracellular vesicles and their potential significance in the pathogenesis and treatment of osteoarthritis. Pharmaceuticals. 2021;14:315.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Skotland T, Sagini K, Sandvig K, Llorente A. An emerging focus on lipids in extracellular vesicles. Adv Drug Deliv Rev. 2020;159:308–21.

Article  CAS  PubMed  Google Scholar 

Boere J. Extracellular vesicles in synovial fluid: dynamics during joint inflammation and articular development and promise for joint regeneration and restoration of joint homeostasis; 2017. PhD Thesis, University Utrecht, the Netherlands.

Google Scholar 

Arévalo-Turrubiarte M, Baratta M, Ponti G, Chiaradia E, Martignani E. Extracellular vesicles from equine mesenchymal stem cells decrease inflammation markers in chondrocytes in vitro. Equine Vet J. 2022;54:1133–43.

Article  PubMed  Google Scholar 

Hotham WE, Thompson C, Szu-Ting L, Henson FMD. The anti-inflammatory effects of equine bone marrow stem cell-derived extracellular vesicles on autologous chondrocytes. Vet Rec Open. 2021;8:e22.

Article  PubMed  PubMed Central  Google Scholar 

Kim KH, Park TS, Cho B-W, Kim TM. Nanoparticles from equine fetal bone marrow-derived cells enhance the survival of injured chondrocytes. Animals. 2020;10:1723.

Article  PubMed  PubMed Central  Google Scholar 

Fuchs B, Bondzio A, Wagner U, Schiller J. Phospholipid compositions of sera and synovial fluids from dog, human and horse: a comparison by 31P-NMR and MALDI-TOF MS. J Anim Physiol Anim Nutr. 2009;93:410–22.

Article  CAS  Google Scholar 

Kosinska MK, Eichner G, Schmitz G, Liebisch G, Steinmeyer J. A comparative study on the lipidome of normal knee synovial fluid from humans and horses. PLoS One. 2021;16:e0250146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mustonen A-M, Lehmonen N, Oikari S, Capra J, Raekallio M, Mykkänen A, et al. Counts of hyaluronic acid-containing extracellular vesicles decrease in naturally occurring equine osteoarthritis. Sci Rep. 2022;12:17550.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mustonen A-M, Käkelä R, Lehenkari P, Huhtakangas J, Turunen S, Jou-kainen A, et al. Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis. Arthritis Res Ther. 2019;21:124.

Article  PubMed  PubMed Central  Google Scholar 

Schlueter AE, Orth MW. Equine osteoarthritis: a brief review of the disease and its causes. Equine Comp Exerc Physiol. 2004;1:221–31.

Article  Google Scholar 

Innes JK, Calder PC. Omega-6 fatty acids and inflammation. Prostaglandins Leukot Essent Fat Acids. 2018;132:41–8.

Article  CAS  Google Scholar 

Oksanen HE, Thafvelin B. Fatty acid composition of hay. J Dairy Sci. 1965;48:1305–9.

Article  CAS  PubMed  Google Scholar 

Zhou M, Robards K, Glennie-Holmes M, Helliwell S. Oat lipids. J Am Oil Chem Soc. 1999;76:159–69.

Article  CAS  Google Scholar 

Mustonen A-M, Käkelä R, Joukainen A, Lehenkari P, Jaroma A, Kääriäinen T, et al. Synovial fluid fatty acid profiles are differently altered by inflammatory joint pathologies in the shoulder and knee joints. Biology. 2021;10:401.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosell MS, Lloyd-Wright Z, Appleby PN, Sanders TAB, Allen NE, Key TJ. Long-chain n–3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men. Am J Clin Nutr. 2005;82:327–34.

Article  CAS  PubMed  Google Scholar 

Lippiello L, Walsh T, Fienhold M. The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage. Metabolism. 1991;40:571–6.

Article  CAS  PubMed  Google Scholar 

Plumb MS, Aspden RM. High levels of fat and (n-6) fatty acids in cancellous bone in osteoarthritis. Lipids Health Dis. 2004;3:12.

Article  PubMed  PubMed Central  Google Scholar 

Cillero-Pastor B, Eijkel G, Kiss A, Blanco FJ, Heeren RMA. Time-of-flight secondary ion mass spectrometry-based molecular distribution distinguishing healthy and osteoarthritic human cartilage. Anal Chem. 2012;84:8909–16.

Article  CAS  PubMed  Google Scholar 

Humphries JM, Kuliwaba JS, Gibson RJ, Fazzalari NL. In situ fatty acid profile of femoral cancellous subchondral bone in osteoarthritic and fragility fracture females: implications for bone remodelling. Bone. 2012;51:218–23.

Article  CAS  PubMed  Google Scholar 

Navarro E, Esteve M, Olivé A, Klaassen J, Cabré E, Tena X, et al. Abnormal fatty acid pattern in rheumatoid arthritis. A rationale for treatment with marine and botanical lipids. J Rheumatol. 2000;27:298–303.

CAS  PubMed  Google Scholar 

Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, et al. Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthr Cartil. 2012;20:382–7.

Article  CAS  Google Scholar 

Wu C-L, Jain D, McNeill JN, Little D, Anderson JA, Huebner JL, et al. Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. Ann Rheum Dis. 2015;74:2076–83.

Article  CAS  PubMed  Google Scholar 

Wu C-L, Kimmerling KA, Little D, Guilak F. Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair. Sci Rep. 2017;7:44315.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loef M, Ioan-Facsinay A, Mook-Kanamori DO, Willems van Dijk K, de Mutsert R, Kloppenburg M, et al. The association of plasma fatty acids with hand and knee osteoarthritis: the NEO study. Osteoarthr Cartil. 2020;28:223–30.

Article  CAS  Google Scholar 

Sibille KT, King C, Garrett TJ, Glover TL, Zhang H, Chen H, et al. Omega-6:omega-3 PUFA ratio, pain, functioning, and distress in adults with knee pain. Clin J Pain. 2018;34:182–9.

Article  PubMed  PubMed Central  Google Scholar 

Mustonen A-M, Käkelä R, Finnilä MAJ, Sawatsky A, Korhonen RK, Saarakkala S, et al. Anterior cruciate ligament transection alters the n-3/n-6 fatty acid balance in the lapine infrapatellar fat pad. Lipids Health Dis. 2019;18:67.

Article  PubMed  PubMed Central  Google Scholar 

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