S-ketamine: Is it a ride worth taking? Adverse effects associated with S-ketamine use as an adjuvant or single agent drug

Elsevier

Available online 14 March 2023, 101233

Trends in Anaesthesia and Critical CareAuthor links open overlay panelHighlights•

S-ketamine use induces multiple adverse events.

Specific drug combinations attenuate s-ketamine induced side effects.

The occurrence and severity of s-ketamine induced adverse effects varies depending on the type of patients.

Abstract

S(+)-ketamine, more commonly referred to as s-ketamine or esketamine has proven to be an important addition to the clinical anesthesia field and beyond. However, its use may prompt a wide range of adverse effects including dizziness, nausea, vomiting, increased airway secretions, increased heart rate and increased blood pressure. Multiple factors such as age, gender and dosage have an impact on the occurrence and severity of these adverse events. A thorough understanding of these influences is essential to counteracting them.

This review will be centered on recently published data concerning the adverse effects and complications elicited by the clinical application of s-ketamine, with the intention of highlighting how these side effects vary in incidence and severity across diverse settings.

Keywords

s-ketamine

Adverse events

Anesthesia

Analgesia

Sedation

Anti-depression

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© 2023 Published by Elsevier Ltd.

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