Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.

Article  PubMed  Google Scholar 

Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61:759–67.

Article  CAS  PubMed  Google Scholar 

Bettington M, Walker N, Clouston A, et al. The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology. 2013;62(3):367–86.

Article  PubMed  Google Scholar 

Rosty C, Hewett DG, Brown IS, et al. Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management. J Gastroenterol. 2013;48:287–302.

Article  PubMed  Google Scholar 

Nguyen HT, Duong HQ. The molecular characteristics of colorectal cancer: implications for diagnosis and therapy. Oncol Lett. 2018;16(1):9–18.

PubMed  PubMed Central  Google Scholar 

Nakamura F, Sato Y, Okamoto K, et al. Colorectal carcinoma occurring via the adenoma-carcinoma pathway in patients with serrated polyposis syndrome. J Gastroenterol. 2022;57:286–99.

Article  CAS  PubMed  Google Scholar 

Shimohara Y, Urabe Y, Oka S, et al. Clinicopathological characteristics of colorectal serrated polyposis syndrome (SPS): results of a multicenter study by the SPS Study Group in Japan. J Gastroenterol. 2022;57:300–8.

Article  PubMed  Google Scholar 

Howe JR, Sayed MG, Ahmed AF, et al. The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet. 2004;41:484–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Woodford-Richens K, Bevan S, Churchman M, et al. Analysis of genetic and phenotypic heterogeneity in juvenile polyposis. Gut. 2000;46:656–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miyazono K, Maeda S, Imamura T. BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev. 2005;16:251–63.

Article  CAS  PubMed  Google Scholar 

Auclair BA, Benoit YD, Rivard N, et al. Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage. Gastroenterology. 2007;133:887–96.

Article  CAS  PubMed  Google Scholar 

Allaire JM, Roy SAB, Ouellet C, et al. Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation. Int J Cancer. 2016;138:2700–12.

Article  CAS  PubMed  Google Scholar 

Ouahoud S, Westendorp BF, Voorneveld PW, et al. Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development. J Gastroenterol. 2022;58:25–43.

Article  PubMed  PubMed Central  Google Scholar 

Guinney J, Dienstmann R, Wang X, et al. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015;21:1350–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feig C, Jones JO, Kraman M, et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer. Proc Natl Acad Sci USA. 2013;110:20212–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turkes F, Mencel J, Starling N. Targeting the immune milieu in gastrointestinal cancers. J Gastroenterol. 2020;55:909–26.

Article  PubMed  PubMed Central  Google Scholar