β-Adrenoceptor Blockade Moderates Neuroinflammation in Male and Female EAE Rats and Abrogates Sexual Dimorphisms in the Major Neuroinflammatory Pathways by Being More Efficient in Males

Acaz-Fonseca E, Duran JC, Carrero P, Garcia-Segura LM, Arevalo MA (2015) Sex differences in glia reactivity after cortical brain injury. Glia 63:1966–1981. https://doi.org/10.1002/glia.22867

Article  PubMed  Google Scholar 

Adamczyk B, Adamczyk-Sowa M (2016) New insights into the role of oxidative stress mechanisms in the pathophysiology and treatment of multiple sclerosis. Oxid Med Cell Longev 2016:1973834. https://doi.org/10.1155/2016/1973834

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alhazzani K, Ahmad SF, Al-Harbi NO, Attia SM, Bakheet SA, SarawiW ASA, Algahtani M, Nadeem A (2021) Pharmacological inhibition of STAT3 by stattic ameliorates clinical symptoms and reduces autoinflammation in myeloid, lymphoid, and neuronal tissue compartments in relapsing-remitting model of experimental autoimmune encephalomyelitis in SJL/J mice. Pharmaceutics 13:925. https://doi.org/10.3390/pharmaceutics13070925

Article  CAS  PubMed  PubMed Central  Google Scholar 

Almolda B, Costa M, Montoya M, González B, Castellano B (2009) CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model. J Neuroimmunol 209:65–80. https://doi.org/10.1016/j.jneuroim.2009.01.026

Article  CAS  PubMed  Google Scholar 

Alvarez DF, Helm K, DeGregori J, Roederer M, Majka S (2010) Publishing flow cytometry data. Am J Physiol Lung Cell Mol Physiol 298:L127–L130. https://doi.org/10.1152/ajplung.00313.2009

Article  CAS  PubMed  Google Scholar 

Arra A, Lingel H, Kuropka B, Pick J, Schnoeder T, Fischer T, Freund C, Pierau M, Brunner-Weinzierl MC (2017) The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs. Oncoimmunology 6:e1273300. https://doi.org/10.1080/2162402X.2016.1273300

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babon JJ, Varghese LN, Nicola NA (2014) Inhibition of IL-6 family cytokines by SOCS3. Semin Immunol 26:13–19. https://doi.org/10.1016/j.smim.2013.12.004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barbieri A, Robinson N, Palma G, Maurea N, Desiderio V, Botti G (2020) Can beta-2-adrenergic pathway be a new target to combat SARS-CoV-2 hyperinflammatory syndrome?—Lessons learned from cancer. Front Immunol 11:588724. https://doi.org/10.3389/fimmu.2020.588724

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benarroch EE (2018) Locus coeruleus. Cell Tissue Res 373:221–232. https://doi.org/10.1007/s00441-017-2649-1

Article  PubMed  Google Scholar 

Benusa SD, Lafrenaye AD (2020) Microglial process convergence on axonal segments in health and disease. Neuroimmunol Neuroinflamm 7:23–39. https://doi.org/10.20517/2347-8659.2019.28

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bogdan C (2015) Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol 36:161–178. https://doi.org/10.1016/j.it.2015.01.003

Article  CAS  PubMed  Google Scholar 

Bordeleau M, Carrier M, Luheshi GN, Tremblay MÈ (2019) Microglia along sex lines: from brain colonization, maturation and function, to implication in neurodevelopmental disorders. Semin Cell Dev Biol 94:152–163. https://doi.org/10.1016/j.semcdb.2019.06.001

Article  PubMed  Google Scholar 

Bove R, Chitnis T (2014) The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis. Mult Scler 20:520–526. https://doi.org/10.1177/1352458513519181

Article  CAS  PubMed  Google Scholar 

Braun DA, Fribourg M, Sealfon SC (2013) Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation. J Biol Chem 288:2986–2993. https://doi.org/10.1074/jbc.M112.386573

Article  CAS  PubMed  Google Scholar 

Brown BN, Valentin JE, Stewart-Akers AM, McCabe GP, Badylak SF (2009) Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component. Biomaterials 30:1482–1491. https://doi.org/10.1016/j.biomaterials.2008.11.040

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bruce-Keller AJ, Dimayuga FO, Reed JL, Wang C, Angers R, Wilson ME, Dimayuga VM, Scheff SW (2007) Gender and estrogen manipulation do not affect traumatic brain injury in mice. J Neurotrauma 24:203–215. https://doi.org/10.1089/neu.2006.0163

Article  PubMed  Google Scholar 

Cai W, Dai X, Chen J, Zhao J, Xu M, Zhang L, Yang B, Zhang W, Rocha M, Nakao T, Kofler J, Shi Y, Stetler RA, Hu X, Chen J (2019) STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice. JCI Insight 4:e131355. https://doi.org/10.1172/jci.insight.131355

Article  PubMed  PubMed Central  Google Scholar 

Carow B, Rottenberg ME (2014) SOCS3, a major regulator of infection and inflammation. Front Immunol 5:58. https://doi.org/10.3389/fimmu.2014.00058

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cassatella MA, Gasperini S, Bovolenta C, Calzetti F, Vollebregt M, Scapini P, Marchi M, Suzuki R, Suzuki A, Yoshimura A (1999) Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation. Blood 94:2880–2889. https://doi.org/10.1182/blood.V94.8.2880.420k31_2880_2889

Article  CAS  PubMed  Google Scholar 

Castro-Sánchez S, García-Yagüe ÁJ, Kügler S, Lastres-Becker I (2019) CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: implications in tauopathies. Redox Biol 22:101118. https://doi.org/10.1016/j.redox.2019.101118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cevey ÁC, Penas FN, Alba Soto CD, Mirkin GA, Goren NB (2019) IL-10/STAT3/SOCS3 Axis Is Involved in the anti-inflammatory effect of benznidazole. Front Immunol 10:1267. https://doi.org/10.3389/fimmu.2019.01267

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charan J, Kantharia ND (2013) How to calculate sample size in animal studies? J Pharmacol Pharmacother 4:303–306. https://doi.org/10.4103/0976-500X.119726

Article  PubMed  PubMed Central  Google Scholar 

Chen S, Dong Z, Cheng M, Zhao Y, Wang M, Sai N, Wang X, Liu H, Huang G, Zhang X (2017) Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke. J Neuroinflammation 14:187. https://doi.org/10.1186/s12974-017-0963-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi BY, Kim JH, Kho AR, Kim IY, Lee SH, Lee BE, Choi E, Sohn M, Stevenson M, Chung TN, Kauppinen TM, Suh SW (2015) Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice. J Neuroinflammation 12:104. https://doi.org/10.1186/s12974-015-0325-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Codarri L, Gyülvészi G, Tosevski V, Hesske L, Fontana A, Magnenat L, Suter T, Becher B (2011) RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12:560–567. https://doi.org/10.1038/ni.2027

Article  CAS  PubMed  Google Scholar 

Corraliza IM, Soler G, Eichmann K, Modolell M (1995) Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages. Biochem Biophys Res Commun 206:667–673. https://doi.org/10.1006/bbrc.1995.1094

Article  CAS  PubMed  Google Scholar 

Cuadrado A, Rojo AI (2008) Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Curr Pharm Des 14:429–442. https://doi.org/10.2174/138161208783597407

Article  CAS  PubMed  Google Scholar 

Dang C, Lu Y, Chen X, Li Q (2021) Baricitinib ameliorates experimental autoimmune encephalomyelitis by modulating the janus kinase/signal transducer and activator of transcription signaling pathway. Front Immunol 12:650708. https://doi.org/10.3389/fimmu.2021.650708

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dart AM, Lewis MJ, Groom GV, Meek EM, Henderson AH (1981) The effect of chronic propranolol treatment on overnight plasma levels of anterior pituitary and related hormones. Br J Clin Pharmacol 12:849–853. https://doi.org/10.1111/j.1365-2125.1981.tb01319.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng X, Berletch JB, Nguyen DK, Disteche CM (2014) X chromosome regulation: diverse patterns in development, tissues and disease. Nat Rev Genet 15:367–378. https://doi.org/10.1038/nrg3687

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding Y, Chen D, Tarcsafalvi A, Su R, Qin L, Bromberg JS (2003) Suppressor of cytokine signaling 1 inhibits IL-10-mediated immune responses. J Immunol 170:1383–1391. https://doi.org/10.4049/jimmunol.170.3.1383

Article  CAS  PubMed  Google Scholar 

Dinkova-Kostova AT, Kostov RV, Kazantsev AG (2018) The role of Nrf 2 signaling in counteracting neurodegenerative diseases. FEBS J 285:3576–3590. https://doi.org/10.1111/febs.14379

Article  CAS  PubMed  PubMed Central  Google Scholar 

Djikić J, Nacka-Aleksić M, Pilipović I, Stojić-Vukanić Z, Bufan B, Kosec D, Dimitrijević M, Leposavić G (2014) Age-associated changes in rat immune system: lessons learned from experimental autoimmune encephalomyelitis. Exp Gerontol 58:179–197. https://doi.org/10.1016/j.exger.2014.08.005

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