Pulsed Electromagnetic Fields Protect Against Brain Ischemia by Modulating the Astrocytic Cholinergic Anti-inflammatory Pathway

Cao M, MacDonald JW, Liu HL, Weaver M, Cortes M, Durosier LD, Burns P, Fecteau G, Desrochers A, Schulkin J, Antonelli MC, Bernier RA, Dorschner M, Bammler TK, Frasch MG (2019) alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin. Front Immunol 10:1063. https://doi.org/10.3389/fimmu.2019.01063

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chamorro A, Dirnagl U, Urra X, Planas AM (2016) Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. Lancet Neurol 15(8):869–881. https://doi.org/10.1016/S1474-4422(16)00114-9

Article  CAS  PubMed  Google Scholar 

Chan P, Eng LF, Lee YL, Lin VW (1999) Effects of pulsed magnetic stimulation of GFAP levels in cultured astrocytes. J Neurosci Res 55(2):238–244. https://doi.org/10.1002/(SICI)1097-4547(19990115)55:2%3c238::AID-JNR11%3e3.0.CO;2-T

Article  CAS  PubMed  Google Scholar 

Charan J, Kantharia ND (2013) How to calculate sample size in animal studies? J Pharmacol Pharmacother 4(4):303–306. https://doi.org/10.4103/0976-500X.119726

Article  PubMed  PubMed Central  Google Scholar 

Cheng X, Yeung PKK, Zhong K, Zilundu PLM, Zhou L, Chung SK (2019) Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke. J Neuroinflamm 16(1):227. https://doi.org/10.1186/s12974-019-1597-y

Article  CAS  Google Scholar 

Dajas-Bailador FA, Lima PA, Wonnacott S (2000) The alpha7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca(2+) dependent mechanism. Neuropharmacology 39(13):2799–2807. https://doi.org/10.1016/s0028-3908(00)00127-1

Article  CAS  PubMed  Google Scholar 

Dayan E, Censor N, Buch ER, Sandrini M, Cohen LG (2013) Noninvasive brain stimulation: from physiology to network dynamics and back. Nat Neurosci 16(7):838–844. https://doi.org/10.1038/nn.3422

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faul F, Erdfelder E, Buchner A, Lang AG (2009) Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 41(4):1149–1160. https://doi.org/10.3758/BRM.41.4.1149

Article  PubMed  Google Scholar 

Gamage R, Wagnon I, Rossetti I, Childs R, Niedermayer G, Chesworth R, Gyengesi E (2020) Cholinergic modulation of glial function during aging and chronic neuroinflammation. Front Cell Neurosci 14:577912. https://doi.org/10.3389/fncel.2020.577912

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gatson JW, Simpkins JW, Uteshev VV (2015) High therapeutic potential of positive allosteric modulation of alpha7 nAChRs in a rat model of traumatic brain injury: proof-of-concept. Brain Res Bull 112:35–41. https://doi.org/10.1016/j.brainresbull.2015.01.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

GBDS (2021) Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 20(10):795–820. https://doi.org/10.1016/S1474-4422(21)00252-0

Article  Google Scholar 

Han QQ, Yin M, Wang ZY, Liu H, Ao JP, Wang YX (2020) Cynandione A alleviates neuropathic pain through alpha7-nAChR-dependent IL-10/beta-endorphin signaling complexes. Front Pharmacol 11:614450. https://doi.org/10.3389/fphar.2020.614450

Article  CAS  PubMed  Google Scholar 

He GL, Liu Y, Li M, Chen CH, Gao P, Yu ZP, Yang XS (2014) The amelioration of phagocytic ability in microglial cells by curcumin through the inhibition of EMF-induced pro-inflammatory responses. J Neuroinflamm 11:49. https://doi.org/10.1186/1742-2094-11-49

Article  CAS  Google Scholar 

He GL, Luo Z, Shen TT, Li P, Yang J, Luo X, Chen CH, Gao P, Yang XS (2016) Inhibition of STAT3- and MAPK-dependent PGE2 synthesis ameliorates phagocytosis of fibrillar beta-amyloid peptide (1–42) via EP2 receptor in EMF-stimulated N9 microglial cells. J Neuroinflamm 13(1):296. https://doi.org/10.1186/s12974-016-0762-9

Article  CAS  Google Scholar 

Kelso ML, Oestreich JH (2012) Traumatic brain injury: central and peripheral role of alpha7 nicotinic acetylcholine receptors. Curr Drug Targets 13(5):631–636. https://doi.org/10.2174/138945012800398964

Article  CAS  PubMed  Google Scholar 

Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipovic SR, Grefkes C, Hasan A, Hummel FC, Jaaskelainen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorova I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U (2020) Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018). Clin Neurophysiol 131(2):474–528. https://doi.org/10.1016/j.clinph.2019.11.002

Article  PubMed  Google Scholar 

Lei T, Liang Z, Li F, Tang C, Xie K, Wang P, Dong X, Shan S, Jiang M, Xu Q, Luo E, Shen G (2018) Pulsed electromagnetic fields (PEMF) attenuate changes in vertebral bone mass, architecture and strength in ovariectomized mice. Bone 108:10–19. https://doi.org/10.1016/j.bone.2017.12.008

Article  CAS  PubMed  Google Scholar 

Lenz M, Galanis C, Muller-Dahlhaus F, Opitz A, Wierenga CJ, Szabo G, Ziemann U, Deller T, Funke K, Vlachos A (2016) Repetitive magnetic stimulation induces plasticity of inhibitory synapses. Nat Commun 7:10020. https://doi.org/10.1038/ncomms10020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Luo P, Wang F, Yang Q, Li Y, Zhao M, Wang S, Wang Q, Xiong L (2014) Inhibition of N-myc downstream-regulated gene-2 is involved in an astrocyte-specific neuroprotection induced by sevoflurane preconditioning. Anesthesiology 121(3):549–562. https://doi.org/10.1097/ALN.0000000000000314

Article  CAS  PubMed  Google Scholar 

Li X, Xu H, Lei T, Yang Y, Jing D, Dai S, Luo P, Xu Q (2017) A pulsed electromagnetic field protects against glutamate-induced excitotoxicity by modulating the endocannabinoid system in HT22 cells. Front Neurosci 11:42. https://doi.org/10.3389/fnins.2017.00042

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Song Y, He T, Wen R, Li Y, Chen T, Huang S, Wang Y, Tang Y, Shen F, Tian HL, Yang GY, Zhang Z (2021) M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice. Theranostics 11(3):1232–1248. https://doi.org/10.7150/thno.48761

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu H, Wu X, Luo J, Wang X, Guo H, Feng D, Zhao L, Bai H, Song M, Liu X, Guo W, Li X, Yue L, Wang B, Qu Y (2019) Pterostilbene attenuates astrocytic inflammation and neuronal oxidative injury after ischemia-reperfusion by inhibiting NF-kappaB phosphorylation. Front Immunol 10:2408. https://doi.org/10.3389/fimmu.2019.02408

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo D, Zhang Y, Yuan X, Pan Y, Yang L, Zhao Y, Zhuo R, Chen C, Peng L, Li W, Jin X, Zhou Y (2019a) Oleoylethanolamide inhibits glial activation via modulating PPARalpha and promotes motor function recovery after brain ischemia. Pharmacol Res 141:530–540. https://doi.org/10.1016/j.phrs.2019.01.027

Article  CAS  PubMed  Google Scholar 

Luo P, Li X, Wu X, Dai S, Yang Y, Xu H, Jing D, Rao W, Xu H, Gao X, Fei Z, Lu H (2019b) Preso regulates NMDA receptor-mediated excitotoxicity via modulating nitric oxide and calcium responses after traumatic brain injury. Cell Death Dis 10(7):496. https://doi.org/10.1038/s41419-019-1731-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Z, Zhang Z, Bai F, Jiang T, Yan C, Wang Q (2019) Electroacupuncture pretreatment alleviates cerebral ischemic injury through alpha7 nicotinic acetylcholine receptor-mediated phenotypic conversion of microglia. Front Cell Neurosci 13:537. https://doi.org/10.3389/fncel.2019.00537

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moya Gomez A, Font LP, Brone B, Bronckaers A (2021) Electromagnetic field as a treatment for cerebral ischemic stroke. Front Mol Biosci 8:742596. https://doi.org/10.3389/fmolb.2021.742596

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel H, McIntire J, Ryan S, Dunah A, Loring R (2017) Anti-inflammatory effects of astroglial alpha7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-kappaB pathway and activation of the Nrf2 pathway. J Neuroinflamm 14(1):192. https://doi.org/10.1186/s12974-017-0967-6

Article  CAS  Google Scholar 

Pena-Philippides JC, Yang Y, Bragina O, Hagberg S, Nemoto E, Roitbak T (2014) Effect of pulsed electromagnetic field (PEMF) on infarct size and inflammation after cerebral ischemia in mice. Transl Stroke Res 5(4):491–500. https://doi.org/10.1007/s12975-014-0334-1

Article  CAS  PubMed  Google Scholar 

Piovesana R, Salazar Intriago MS, Dini L, Tata AM (2021) Cholinergic modulation of neuroinflammation: focus on alpha7 nicotinic receptor. Int J Mol Sci 22:9. https://doi.org/10.3390/ijms22094912

Article  CAS  Google Scholar 

Rasouli J, Lekhraj R, White NM, Flamm ES, Pilla AA, Strauch B, Casper D (2012) Attenuation of interleukin-1beta by pulsed electromagnetic fields after traumatic brain injury. Neurosci Lett 519(1):4–8. https://doi.org/10.1016/j.neulet.2012.03.089

Article  CAS  PubMed  Google Scholar 

Schuhmann MK, Papp L, Stoll G, Blum R, Volkmann J, Fluri F (2021) Mesencephalic electrical stimulation reduces neuroinflammation after photothrombotic stroke in rats by targeting the cholinergic anti-inflammatory pathway. Int J Mol Sci 22:3. https://doi.org/10.3390/ijms22031254

Article  CAS  Google Scholar 

Shao X, Yan Z, Wang D, Yang Y, Ding Y, Luo E, Jing D, Cai J (2021) Pulsed electromagnetic fields ameliorate skeletal deterioration in bone mass, microarchitecture, and strength by enhancing canonical wnt signaling-mediated bone formation in rats with spinal cord injury. J Neurotrauma 38(6):765–776. https://doi.org/10.1089/neu.2020.7296

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif