Bousquet PJ, Leynaert B, Neukirch F, Sunyer J, Janson CM, Anto J, et al. Geographical distribution of atopic rhinitis in the european community respiratory health survey I. Allergy. 2008;63(10):1301–9.

Article  PubMed  Google Scholar 

Cheng L, Chen J, Fu Q, He S, Li H, Liu Z, et al. Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res. 2018;10(4):300–53.

Article  PubMed  PubMed Central  Google Scholar 

Song Y, Wang M, Xie J, Li W, Zhang X, Wang T, et al. Prevalence of allergic rhinitis among elementary and middle school students in changsha city and its impact on quality of life. J Laryngol Otol. 2015;129(11):1108–14.

Article  CAS  PubMed  Google Scholar 

Zhong Z, Wang F, Wang T, Li L, Tan G. Aeroallergen spectrum of patients with child allergic rhinitis in Changsha area of China. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011;25(17):774–6.

PubMed  Google Scholar 

Bousquet J, Van Cauwenberge P, Khaltaev N, Aria WG, World Health O. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108(5 Suppl):S147-334.

Article  CAS  PubMed  Google Scholar 

Castner J, Barnett R, Moskos LH, Folz RJ, Polivka B. Home environment allergen exposure scale in older adult cohort with asthma. Can J Public Health. 2020. https://doi.org/10.17269/s41997-020-00335-0.

Article  PubMed  PubMed Central  Google Scholar 

Berings M, Karaaslan C, Altunbulakli C, Gevaert P, Akdis M, Bachert C, et al. Advances and highlights in allergen immunotherapy: on the way to sustained clinical and immunologic tolerance. J Allergy Clin Immunol. 2017;140(5):1250–67.

Article  CAS  PubMed  Google Scholar 

Lam HY, Tergaonkar V, Ahn KS. Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies. 2020. Biosci Rep. https://doi.org/10.1042/BSR20200256.

Roberts G, Pfaar O, Akdis CA, Ansotegui IJ, Durham SR, Gerth van Wijk R, et al. EAACI guidelines on allergen immunotherapy: allergic rhinoconjunctivitis. Allergy. 2018;73(4):765–98.

Article  CAS  PubMed  Google Scholar 

Liu W, Zeng Q, He C, Chen R, Tang Y, Yan S, et al. Compliance, efficacy, and safety of subcutaneous and sublingual immunotherapy in children with allergic rhinitis. Pediatr Allergy Immunol. 2021;32(1):86–91.

Article  CAS  PubMed  Google Scholar 

Kim JY, Jang MJ, Kim DY, Park SW, Han DH. Efficacy of subcutaneous and sublingual immunotherapy for house dust mite allergy: a network meta-analysis-based comparison. J Allergy Clin Immunol Pract. 2021;9(12):4450-8e6.

Article  CAS  PubMed  Google Scholar 

Tabar AI, Echechipia S, Garcia BE, Olaguibel JM, Lizaso MT, Gomez B, et al. Double-blind comparative study of cluster and conventional immunotherapy schedules with Dermatophagoides pteronyssinus. J Allergy Clin Immunol. 2005;116(1):109–18.

Article  PubMed  Google Scholar 

Pfaar O, Klimek L, Fischer I, Sieber J, Amoroso S, Moreno Aguilar C, et al. Safety of two cluster schedules for subcutaneous immunotherapy in allergic rhinitis or asthma patients sensitized to inhalant allergens. Int Arch Allergy Immunol. 2009;150(1):102–8.

Article  CAS  PubMed  Google Scholar 

Schubert R, Eickmeier O, Garn H, Baer PC, Mueller T, Schulze J, et al. Safety and immunogenicity of a cluster specific immunotherapy in children with bronchial asthma and mite allergy. Int Arch Allergy Immunol. 2009;148(3):251–60.

Article  CAS  PubMed  Google Scholar 

Fan Q, Liu X, Gao J, Huang S, Ni L. Comparative analysis of cluster versus conventional immunotherapy in patients with allergic rhinitis. Exp Ther Med. 2017;13(2):717–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mailing HJ, Weeke B. Position paper: Immunotherapy. Allergy. 1993;48(14 Suppl):9–35.

Zhang L, Wang C, Han D, Wang X, Zhao Y, Liu J. Comparative study of cluster and conventional immunotherapy schedules with dermatophagoides pteronyssinus in the treatment of persistent allergic rhinitis. Int Arch Allergy Immunol. 2009;148(2):161–9.

Article  CAS  PubMed  Google Scholar 

Bernstein DI, Epstein T, Murphy-Berendts K, Liss GM. Surveillance of systemic reactions to subcutaneous immunotherapy injections: year 1 outcomes of the ACAAI and AAAAI collaborative study. Ann Allergy Asthma Immunol. 2010;104(6):530–5.

Article  PubMed  PubMed Central  Google Scholar 

Song Y, Long J, Wang T, Xie J, Wang M, Tan G. Long-term efficacy of standardised specific subcutaneous immunotherapy in children with persistent allergic rhinitis due to multiple allergens including house dust mites. J Laryngol Otol. 2018;132(3):230–5.

Article  CAS  PubMed  Google Scholar 

Nelson HS, Makatsori M, Calderon MA. Subcutaneous immunotherapy and sublingual immunotherapy: comparative efficacy, current and potential indications, and warnings-united states versus Europe. Immunol Allergy Clin North Am. 2016;36(1):13–24.

Article  PubMed  Google Scholar 

Sahin E, Dizdar D, Dinc ME, Cirik AA. Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis. J Laryngol Otol. 2017;131(11):997–1001.

Article  CAS  PubMed  Google Scholar 

Jacobsen L, Niggemann B, Dreborg S, Ferdousi HA, Halken S, Host A, et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy. 2007;62(8):943–8.

Article  CAS  PubMed  Google Scholar 

Jutel M, Brüggenjürgen B, Richter H, Vogelberg C. Real-world evidence of subcutaneous allergoid immunotherapy in house dust mite-induced allergic rhinitis and asthma. Allergy. 2020;75(8):2050–8.

Article  PubMed  Google Scholar 

Huang Y, Wang C, Cao F, Zhao Y, Lou H, Zhang L. Comparison of long-term efficacy of subcutaneous immunotherapy in pediatric and adult patients with allergic rhinitis. Allergy Asthma Immunol Res. 2019;11(1):68–78.

Article  CAS  PubMed  Google Scholar 

Narkus A, Lehnigk U, Haefner D, Klinger R, Pfaar O, Worm M. The placebo effect in allergen-specific immunotherapy trials. Clin Transl Allergy. 2013;3(1):42.

Article  PubMed  PubMed Central  Google Scholar 

Janiaud P, Cornu C, Lajoinie A, Djemli A, Cucherat M, Kassai B. Is the perceived placebo effect comparable between adults and children? Meta Regres Anal Pediatr Res. 2017;81(1–1):11–7.

Article  Google Scholar 

Pfaar O, Nell MJ, Boot JD, Versteeg SA, van Ree R, Roger A, et al. A randomized, 5-arm dose finding study with a mite allergoid SCIT in allergic rhinoconjunctivitis patients. Allergy. 2016;71(7):967–76.

Article  CAS  PubMed  Google Scholar 

Grouin JM, Vicaut E, Jean-Alphonse S, Demoly P, Wahn U, Didier A, et al. The average adjusted symptom score, a new primary efficacy end-point for specific allergen immunotherapy trials. Clin Exp Allergy. 2011;41(9):1282–8.

Article  PubMed  Google Scholar 

Aasbjerg K, Backer V, Lund G, Holm J, Nielsen NC, Holse M, et al. Immunological comparison of allergen immunotherapy tablet treatment and subcutaneous immunotherapy against grass allergy. Clin Exp Allergy. 2014;44(3):417–28.

Article  CAS  PubMed  Google Scholar 

Mohamadi S, Ahmadzad-Asl M, Nejadghaderi SA, Jabbarinejad R, Mirbehbahani SH, Sinyor M, et al. Systematic review and meta-analysis of the placebo effect and its correlates in obsessive compulsive disorder. Can J Psychiatry. 2022. https://doi.org/10.1177/07067437221115029.

Article  PubMed  Google Scholar 

Di Rienzo V, Marcucci F, Puccinelli P, Parmiani S, Frati F, Sensi L, et al. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study. Clin Exp Allergy. 2003;33(2):206–10.

Article  PubMed  Google Scholar 

Alvaro-Lozano M, Akdis CA, Akdis M, Alviani C, Angier E, Arasi S, et al. EAACI allergen immunotherapy user’s guide. Pediatr Allergy Immunol. 2020;31(Suppl 25):1–101.

Article  PubMed  PubMed Central  Google Scholar 

Kucuksezer UC, Ozdemir C, Cevhertas L, Ogulur I, Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy and allergen tolerance. Allergol Int. 2020;69(4):549–60.

Article  CAS  PubMed  Google Scholar