Testicular neoplasms: the interrelationships of serum levels of microRNA-371a-3p (M371) and classical tumor markers with histology, clinical staging, and age—a statistical analysis

Almstrup K, Lobo J, Morup N, Belge G, Rajpert-DeMeyts E, Looijenga LHJ, Dieckmann KP (2020) Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours. Nat Rev Urol 17(4):201–213

Article  CAS  PubMed  Google Scholar 

Badia RR, Abe D, Wong D, Singla N, Savelyeva A, Chertack N, Woldu SL, Lotan Y, Mauck R, Ouyang D, Meng X, Lewis CM, Majmudar K, Jia L, Kapur P, Xu L, Frazier AL, Margulis V, Strand DW, Coleman N, Murray MJ, Amatruda JF, Lafin JT, Bagrodia A (2021) Real-world application of Pre-orchiectomy miR-371a-3p test in testicular germ cell tumor Management. J Urol 205(1):137–144

Article  PubMed  Google Scholar 

Belge G, Grobelny F, Radtke A, Bodes J, Matthies C, Wülfing C, Dieckmann KP (2020) Serum levels of microRNA-371a-3p are not elevated in testicular tumours of non-germ cell origin. J Cancer Res Clin Oncol 147(2):435–443

Article  PubMed  PubMed Central  Google Scholar 

Beyer J, Collette L, Sauvé N, Daugaard G, Feldman DR, Tandstad T, Tryakin A, Stahl O, Gonzalez-Billalabeitia E, De Giorgi U, Culine S, de Wit R, Hansen AR, Bebek M, Terbuch A, Albany C, Hentrich M, Gietema JA, Negaard H, Huddart RA, Lorch A, Cafferty FH, Heng DYC, Sweeney CJ, Winquist E, Chovanec M, Fankhauser C, Stark D, Grimison P, Necchi A, Tran B, Heidenreich A, Shamash J, Sternberg CN, Vaughn DJ, Duran I, Bokemeyer C, Patrikidou A, Cathomas R, Assele S, Gillessen S (2021) International germ cell cancer classification update consortium survival and new prognosticators in metastatic seminoma: results from the IGCCCG-update consortium. J Clin Oncol 39(14):1553–1562

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bosl GJ, Lange PH, Fraley EE, Goldman A, Nochomovitz LE, Rosai J, Waldmann TA, Johnson K, Kennedy BJ (1981) Human chorionic gonadotropin and alphafetoprotein in the staging of nonseminomatous testicular cancer. Cancer 47(2):328–332

Article  CAS  PubMed  Google Scholar 

Brandt MP, Ruf C, Dieckmann KP, Syring I, Ruckes C, Nestler T, Schmelz HU, Dotzauer R, Hiester A, Albers P, Nettersheim D, Bolenz C, Loosen SH, Heidenreich A, Pfister D, Haferkamp A, Zengerling F, Paffenholz P, Academics Testis GESRU, PCG, (2022) Clinical characteristics, treatment patterns and relapse in patients with clinical stage IS testicular cancer. World J Urol 40:327–334

Article  PubMed  Google Scholar 

Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ (2018) Testicular Cancer. Nat Rev Dis Primers 4(1):29

Article  PubMed  Google Scholar 

Chovanec M, Cheng L (2022) Advances in diagnosis and treatment of testicular cancer. BMJ 379:e070499. https://doi.org/10.1136/bmj-2022-070499

Article  PubMed  Google Scholar 

Daugaard G, Hansen HH, Rorth M (1990) Treatment of malignant germ cell tumors. Ann Oncol 1(3):195–202

Article  CAS  PubMed  Google Scholar 

Dieckmann KP, Anheuser P, Simonsen H, Höflmayer D (2017) Pure testicular seminoma with non-pathologic elevation of alpha fetoprotein: a case series. Urol Int 99(3):353–357

Article  CAS  PubMed  Google Scholar 

Dieckmann KP, Richter-Simonsen H, Kulejewski M, Ikogho R, Zecha H, Anheuser P, Pichlmeier U (2018) Testicular germ-cell tumours: a descriptive analysis of clinical characteristics at first presentation. Urol Int 100(4):409–419

Article  CAS  PubMed  Google Scholar 

Dieckmann KP, Radtke A, Geczi L, Matthies C, Anheuser P, Eckardt U, Sommer J, Zengerling F, Trenti E, Pichler R, Belz H, Zastrow S, Winter A, Melchior S, Hammel J, Kranz J, Bolten M, Krege S, Haben B, Loidl W, Ruf CG, Heinzelbecker J, Heidenreich A, Cremers JF, Oing C, Hermanns T, Fankhauser CD, Gillessen S, Reichegger H, Cathomas R, Pichler M, Hentrich M, Eredics K, Lorch A, Wülfing C, Peine S, Wosniok W, Bokemeyer C, Belge G (2019a) Serum levels of microRNA-371a-3p (M371 Test) as a new biomarker of testicular germ cell-tumors: Results of a prospective multicentric study. J Clin Oncol 37(16):1412–1423

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dieckmann KP, Simonsen-Richter H, Kulejewski M, Anheuser P, Zecha H, Isbarn H, Pichlmeier U (2019b) Serum Tumour markers in testicular germ cell tumours: frequencies of elevated levels and extents of marker elevation are significantly associated with clinical parameters and with response to treatment. BioMed Res Int 2019:5030349. https://doi.org/10.1155/2019/5030349

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dieckmann KP, Isbarn H, Grobelny F, Dumlupinar C, Utschig J, Wülfing C, Pichlmeier U, Belge G (2022a) Testicular neoplasms: primary tumour size is closely interrelated with histology, clinical staging, and tumour marker expression rates - a comprehensive statistical analysis. Cancers (basel) 14(21):5447. https://doi.org/10.3390/cancers14215447

Article  CAS  PubMed  Google Scholar 

Dieckmann KP, Klemke M, Grobelny F, Radtke A, Dralle-Filiz I, Wülfing C, Belge G (2022b) Serum levels of microRNA 371a–3p (M371) can predict absence or presence of vital disease in residual masses after chemotherapy of metatstatic seminoma. Front Oncol 12:889624. https://doi.org/10.3389/fonc.2022.889624

Article  PubMed  PubMed Central  Google Scholar 

Fankhauser CD, Nuño MM, Murray MJ, Frazier L, Bagrodia A (2022) Circulating MicroRNAs for detection of Germ cell tumours: a narrative review. Eur Urol Focus 8(3):660–662. https://doi.org/10.1016/j.euf.2022.04.008

Article  PubMed  Google Scholar 

Fargeot P (1990) Germ cell testicular tumors three therapeutic periods. Bull Cancer Paris. 77(4):331–339

CAS  PubMed  Google Scholar 

Featherstone JM, Fernando HS, Theaker JM, Simmonds PD, Hayes MC, Mead GM (2009) Sex cord stromal testicular tumors: a clinical series–uniformly stage I disease. J Urol 181:2090–2096

Article  CAS  PubMed  Google Scholar 

Friedman NB, Moore RA (1946) Tumors of the testis: a report on 922 cases. Milit Surg 99:573–593

CAS  Google Scholar 

Germa-Lluch JR, Garcia del Muro X, Maroto P, Paz-Ares L, Arranz JA, Guma J, Alba E, Sastre J, Aparicio J, Fernandez A, Barnadas A, Terrassa J, Saenz A, Almenar D, Lopez-Brea M, Climent MA, Sanchez MA, Lasso de la Vega R, Berenguer G, Perez X (2002) Clinical pattern and therapeutic results achieved in 1490 patients with germ-cell tumours of the testis: the experience of the spanish germ-cell cancer group (GG). Eur Urol 42:553–563

Article  CAS  PubMed  Google Scholar 

Gillessen S, Sauvé N, Collette L, Daugaard G, de Wit R, Albany C, Tryakin A, Fizazi K, Stahl O, Gietema JA, De Giorgi U, Cafferty FH, Hansen AR, Tandstad T, Huddart RA, Necchi A, Sweeney CJ, Garcia-Del-Muro X, Heng DYC, Lorch A, Chovanec M, Winquist E, Grimison P, Feldman DR, Terbuch A, Hentrich M, Bokemeyer C, Negaard H, Fankhauser C, Shamash J, Vaughn DJ, Sternberg CN, Heidenreich A, Beyer J (2021) Predicting outcomes in men with metastatic nonseminomatous germ cell tumors (nsgct): results from the IGCCCG update consortium. J Clin Oncol 39(14):1563–1574

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA (2019) Testicular cancer, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 17(12):1529–1554

Article  CAS  PubMed  Google Scholar 

Gobbo A, Negri L, Casale P, Fasulo V, Lughezzani G, Saitta C, Benaglia R, Buffi NM, Levi Setti P (2022) Is testis sparing surgery safe in patients with incidental small testicular lesions referring to a fertility center? A retrospective analysis reporting factors correlated to malignancy and long-term oncological outcomes. Urol Oncol 40(10):457.e9-457.e16. https://doi.org/10.1016/j.urolonc.2022.08.002

Article  PubMed  Google Scholar 

Goebel H, Koeditz B, Huerta M, Kameri E, Nestler T, Kamphausen T, Friemann J, Hamdorf M, Ohrmann T, Koehler P, Cornely OA, Montesinos-Rongen M, Nicol D, Schorle H, Boor P, Quaas A, Pallasch C, Heidenreich A, von Brandenstein M (2022) COVID-19 infection induce miR-371a-3p upregulation resulting in influence on male fertility. Biomedicines 10(4):858. https://doi.org/10.3390/biomedicines10040858

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kausitz J, Ondrus D, Belan V, Matoska J (1992) Monitoring of patients with non-seminomatous germ-cell tumors of the testis by determination of alpha-fetoprotein and beta-human chorionic gonadotropin levels and by computed tomography. Neoplasma 39(6):357–361

CAS  PubMed  Google Scholar 

Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JKC, Chen W, Chen X, Chng WJ, Choi JK, Colmenero I, Coupland SE, Cross NCP, De Jong D, Elghetany MT, Takahashi E, Emile JF, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, Hodge JC, Hu S, Jansen JH, Kanagal-Shamanna R, Kantarjian HM, Kratz CP, Li XQ, Lim MS, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh KN, Natkunam Y, Nejati R, Ott G, Padron E, Patel KP, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C, Hochhaus A (2022) The edition of the world health organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia 36(7):1703–1719

Article  PubMed  PubMed Central  Google Scholar 

Kliesch S, Schmidt S, Wilborn D, Aigner C, Albrecht W, Bedke J, Beintker M, Beyersdorff D, Bokemeyer C, Busch J, Classen J, de Wit M, Dieckmann KP, Diemer T, Dieing A, Gockel M, Göckel-Beining B, Hakenberg OW, Heidenreich A, Heinzelbecker J, Herkommer K, Hermanns T, Kaufmann S, Kornmann M, Kotzerke J, Krege S, Kristiansen G, Lorch A, Müller AC, Oechsle K, Ohloff T, Oing C, Otto U, Pfister D, Pichler R, Recken H, Rick O, Rudolph Y, Ruf C, Schirren J, Schmelz H, Schmidberger H, Schrader M, Schweyer S, Seeling S, Souchon R, Winter C, Wittekind C, Zengerling F, Zermann DH, Zillmann R, Albers P (2021) Management of germ cell tumours of the testis in adult patients german clinical practice guideline part i: epidemiology, classification, diagnosis, prognosis, fertility preservation, and treatment recommendations for localized stages. Urol Int 105(3–4):169–180

Article  PubMed  Google Scholar 

Koch K, Oschlies I, Klapper W (2022) Lymphome und andere hämatologische Neoplasien im Hoden [Lymphomas and other hematological neoplasms in the testicles]. Pathologie (heidelb) 43(6):441–448. https://doi.org/10.1007/s00292-022-01121-0

Article  PubMed  Google Scholar 

Konneh B, Lafin JT, Howard J, Gerald T, Amini A, Savelyeva A, Woldu SL, Lewis CM, Jia L, Margulis V, Coleman N, Scarpini C, Frazier AL, Murray MJ, Amatruda JF, Bagrodia A (2022) Evaluation of miR-371a-3p to predict viable germ cell tumor in patients with pure seminoma receiving retroperitoneal lymph node dissection. Andrology. https://doi.org/10.1111/andr.13317

Article  PubMed  Google Scholar 

Leão R, Ahmad AE, Hamilton RJ (2018) Testicular cancer biomarkers: a role for precision medicine in testicular cancer. Clin Genitourin Cancer 17(1):e176–e183

Article  PubMed 

留言 (0)

沒有登入
gif