Comparison of in vivo behaviors of intramuscularly long-acting celecoxib nanosuspensions with different particle sizes for the postoperative pain treatment
Keywords
Celecoxib
Nanosuspensions
Particle size-dependent pharmacokinetics
Long-acting
Analgesic effects
AbbreviationsAUC
Area under the drug concentration-time profile
Cmax
Maximum plasma concentration
CXB-NS
Celecoxib nanosuspensions
CXB-NSL
Large-sized celecoxib nanosuspensions
CXB-NSM
Medium-sized celecoxib nanosuspensions
CXB-NSs
Small-sized celecoxib nanosuspensions
DSC
Differential scanning calorimetry
FTIR
Fourier transform infrared spectroscopy
HPLC
High-performance liquid chromatography
NSAIDs
Non-steroidal anti-inflammatory drugs
PWT
Paw withdrawal threshold
PXRD
Powder X-ray diffraction
SDS
Sodium dodecyl sulfate
TEM
Transmission electron microscopy
TPGS
D-α-Tocopherol polyethylene glycol 1000 succinate
Tmax
Time to maximum plasma concentration
Data availability
Data will be made available on request.
© 2023 Published by Elsevier B.V.
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