World Health Organization. Global Tuberculosis Report (WHO, 2020).

World Health Organization. Systematic Screening for Active Tuberculosis: Principles and recommendations (WHO, 2013).

Madhi, S. A. et al. COVID-19 lockdowns in low- and middle-income countries: success against COVID-19 at the price of greater costs. S. Afr. Med. J. 110, 724–726 (2020).

Article  CAS  PubMed  Google Scholar 

Dheda, K. et al. The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions. Lancet Respir. Med. 10, 603–622 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dheda, K. et al. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir. Med. S2213-2600, 30079-6 (2017).

Marks, G. B. et al. Community-wide screening for tuberculosis in a high-prevalence setting. N. Engl. J. Med. 381, 1347–1357 (2019).

Article  PubMed  Google Scholar 

Azman, A. S., Golub, J. E. & Dowdy, D. W. How much is tuberculosis screening worth? Estimating the value of active case finding for tuberculosis in South Africa, China, and India. BMC Med. 12, 216 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Sun, A. Y. et al. Modeling the impact of alternative strategies for rapid molecular diagnosis of tuberculosis in Southeast Asia. Am. J. Epidemiol. 178, 1740–1749 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Balcha, T. T., Skogmar, S., Sturegård, E., Björkman, P. & Winqvist, N. Outcome of tuberculosis treatment in HIV-positive adults diagnosed through active versus passive case-finding. Glob. Health Action 8, 27048 (2015).

Article  PubMed  Google Scholar 

Kempker, R. R. et al. High yield of active tuberculosis case finding among HIV-infected patients using Xpert MTB/RIF testing. Open Forum Infect. Dis. 6, ofz233 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Rivera, V. R. et al. Diagnostic yield of active case finding for tuberculosis and HIV at the household level in slums in Haiti. Int. J. Tuberc. Lung Dis. 21, 1140–1146 (2017).

Article  CAS  PubMed  Google Scholar 

Lorent, N. et al. Community-based active tuberculosis case finding in poor urban settlements of Phnom Penh, Cambodia: a feasible and effective strategy. PLoS ONE 9, e92754 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Chen, C. et al. Community-based active case finding for tuberculosis in rural western China: a cross-sectional study. Int. J. Tuberc. Lung Dis. 21, 1134–1139 (2017).

Corbett, E. L. et al. Comparison of two active case-finding strategies for community-based diagnosis of symptomatic smear-positive tuberculosis and control of infectious tuberculosis in Harare, Zimbabwe (DETECTB): a cluster-randomised trial. Lancet 376, 1244–1253 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Morishita, F. et al. Bringing state-of-the-art diagnostics to vulnerable populations: the use of a mobile screening unit in active case finding for tuberculosis in Palawan, the Philippines. PLoS ONE 12, e0171310 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Calligaro, G. L. et al. Effect of new tuberculosis diagnostic technologies on community-based intensified case finding: a multicentre randomised controlled trial. Lancet Infect. Dis. 17, 441–450 (2017).

Article  PubMed  Google Scholar 

Choun, K. et al. Performance of algorithms for tuberculosis active case finding in underserved high-prevalence settings in Cambodia: a cross-sectional study. Glob. Health Action 12, 1646024 (2019).

Article  PubMed  PubMed Central  Google Scholar 

World Health Organization. WHO Consolidated Guidelines on Tuberculosis. Module 2: screening—systematic screening for tuberculosis disease (WHO, 2021).

Burke, R. M. et al. Community-based active case-finding interventions for tuberculosis: a systematic review. Lancet Public Health 6, e283–e299 (2021).

Article  PubMed  PubMed Central  Google Scholar 

World Health Organization, Regional Office for South-East Asia. Optimizing active case-finding for tuberculosis: implementation lessons from South-East Asia (WHO, 2021).

World Health Organization. WHO Consolidated Guidelines on Tuberculosis. Module 3: diagnosis—rapid diagnostics for tuberculosis detection, 2021 update (WHO, 2021).

Davis, J. L., Cattamanchi, A., Cuevas, L. E., Hopewell, P. C. & Steingart, K. R. Diagnostic accuracy of same-day microscopy versus standard microscopy for pulmonary tuberculosis: a systematic review and meta-analysis. Lancet Infect. Dis. 13, 147–154 (2013).

Article  PubMed  Google Scholar 

Meyer, A. J. et al. Sputum quality and diagnostic performance of GeneXpert MTB/RIF among smear-negative adults with presumed tuberculosis in Uganda. PLoS ONE 12, e0180572 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Nalugwa, T. et al. Readiness to implement on-site molecular testing for tuberculosis in community health centers in Uganda. Implement. Sci. Commun. 3, 9 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Cordeiro-Santos, M. et al. Feasibility of GeneXpert((R)) Edge for tuberculosis diagnosis in difficult-to-reach populations: preliminary results of a proof-of-concept study. Am. J. Trop. Med. Hyg. 103, 1065–1066 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khanal, S. et al. Yield of intensified tuberculosis case-finding activities using Xpert® MTB/RIF among risk groups in Nepal. Public Health Action 6, 136–141 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lawn, S. D. et al. Characteristics and early outcomes of patients with Xpert MTB/RIF-negative pulmonary tuberculosis diagnosed during screening before antiretroviral therapy. Clin. Infect. Dis. 54, 1071–1079 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grzybowski, S., Barnett, G. D. & Styblo, K. Contacts of cases of active pulmonary tuberculosis. Bull. Int. Union Tuberc. 50, 90–106 (1975).

CAS  PubMed  Google Scholar 

van Geuns, H. A., Meijer, J. & Styblo, K. Results of contact examination in Rotterdam, 1967–1969. Bull. Int. Union Tuberc. 50, 107–121 (1975).

PubMed  Google Scholar 

Behr, M. A. et al. Transmission of Mycobacterium tuberculosis from patients smear-negative for acid-fast bacilli. Lancet 353, 444–449 (1999).

Article  CAS  PubMed  Google Scholar 

Tostmann, A. et al. Tuberculosis transmission by patients with smear-negative pulmonary tuberculosis in a large cohort in the Netherlands. Clin. Infect. Dis. 47, 1135–1142 (2008).

Article  PubMed  Google Scholar 

Theron, G. et al. Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis. Nat. Med. 26, 1435–1443 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fennelly, K. P. et al. Cough-generated aerosols of Mycobacterium tuberculosis: a new method to study infectiousness. Am. J. Respir. Crit. Care Med. 169, 604–609 (2004).

Jones-Lopez, E. C. et al. Cough aerosols of Mycobacterium tuberculosis predict new infection: a household contact study. Am. J. Respir. Crit. Care Med. 187, 1007–1015 (2013).

Menberu, M. A. Performance of the WHO 2011 TB symptom screening algorithm for pulmonary TB diagnosis among HIV-infected patients in Gondar University Referral Hospital, Ethiopia. Int. J. Microbiol. 2016, 9058109 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Kranzer, K. et al. The benefits to communities and individuals of screening for active tuberculosis disease: a systematic review. Int. J. Tuberc. Lung. Dis. 17, 432–446 (2013).

Article  CAS  PubMed  Google Scholar 

Esmail, A., Tomasicchio, M., Meldau, R., Makambwa, E. & Dheda, K. Comparison of Xpert MTB/RIF (G4) and Xpert Ultra, including trace readouts, for the diagnosis of pulmonary tuberculosis in a TB and HIV endemic setting. Int. J. Infect. Dis. 95, 246–252 (2020).

Article  CAS  PubMed  Google Scholar 

Liang, F., Zhang, S., Wang, Q. & Li, W. Treatment effects measured by restricted mean survival time in trials of immune checkpoint inhibitors for cancer. Ann. Oncol. 29, 1320–1324 (2018).

Article  CAS  PubMed  Google Scholar 

Uno, H. et al. Adding a new analytical procedure with clinical interpretation in the tool box of survival analysis. Ann. Oncol. 29, 1092–1094 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perego, C. et al. Utility of restricted mean survival time analysis for heart failure clinical trial evaluation and interpretation. JACC Heart Fail. 8, 973–983 (2020).

Article  PubMed  Google Scholar 

Peter, J. G., Theron, G., Singh, N., Singh, A. & Dheda, K. Sputum induction to aid diagnosis of smear-negative or sputum-scarce tuberculosis in adults in HIV-endemic settings. Eur. Respir. J. 43, 185–194 (2014).

Article  PubMed  Google Scholar 

Acuna-Villaorduna, C. et al. Cough-aerosol cultures of Mycobacterium tuberculosis in the prediction of outcomes after exposure. A household contact study in Brazil. PLoS ONE 13, e0206384 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Jones-Lopez, E. C. et al. Cough aerosols of Mycobacterium tuberculosis in the prediction of incident tuberculosis disease in household contacts. Clin. Infect. Dis. 63, 10–20 (2016).

Article  PubMed  PubMed Central  Google Scholar