Shah ASV, Stelzle D, Lee KK, et al. Global burden of atherosclerotic cardiovascular disease in people living with HIV: systematic review and meta-analysis. Circulation. 2018;138(11):1100–12.

Article  PubMed  PubMed Central  Google Scholar 

Glovaci D, Fan W, Wong ND. Epidemiology of diabetes mellitus and cardiovascular disease. Curr Cardiol Rep. 2019;21(4):21.

Article  PubMed  Google Scholar 

Camejo G, Waich S, Quintero G, Berrizbeitia ML, Lalaguna F. The affinity of low density lipoproteins for an arterial macromolecular complex. A study in ischemic heart disease and controls. Atherosclerosis. 1976;24(3):341–54.

Article  CAS  PubMed  Google Scholar 

Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. Am J Med. 1977;62(5):707–14.

Article  CAS  PubMed  Google Scholar 

Klerkx AH, El Harchaoui K, van der Steeg WA, et al. Cholesteryl ester transfer protein (CETP) inhibition beyond raising high-density lipoprotein cholesterol levels: pathways by which modulation of CETP activity may alter atherogenesis. Arterioscler Thromb Vasc Biol. 2006;26(4):706–15.

Article  CAS  PubMed  Google Scholar 

Tall AR. Plasma cholesteryl ester transfer protein. J Lipid Res. 1993;34(8):1255–74.

Article  CAS  PubMed  Google Scholar 

Pownall HJ, Rosales C, Gillard BK, Gotto AM Jr. High-density lipoproteins, reverse cholesterol transport and atherogenesis. Nat Rev Cardiol. 2021;18(10):712–23.

Article  CAS  PubMed  Google Scholar 

Wuni R, Kuhnle GGC, Wynn-Jones AA, Vimaleswaran KS. A nutrigenetic update on CETP gene-diet interactions on lipid-related outcomes. Curr Atheroscler Rep. 2022;24(2):119–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su X, Li G, Deng Y, Chang D. Cholesteryl ester transfer protein inhibitors in precision medicine. Clin Chim Acta. 2020;510:733–40.

Article  CAS  PubMed  Google Scholar 

Oestereich F, Yousefpour N, Yang E, et al. The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain. J Lipid Res. 2022;100260. This paper investigates the impact of cholesterol metabolism on brain function, and suggest that CETP activity affects brain health through modulating cholesterol distribution and clearance.

Lim GB. Lipids. Dalcetrapib raises HDL-cholesterol level, but does not reduce cardiac risk. Nat Rev Cardiol. 2013;10(1):5.

Article  PubMed  Google Scholar 

Taheri H, Filion KB, Windle SB, Reynier P, Eisenberg MJ. Cholesteryl ester transfer protein inhibitors and cardiovascular outcomes: a systematic review and meta-analysis of randomized controlled trials. Cardiology. 2020;145(4):236–50.

Article  CAS  PubMed  Google Scholar 

Schmidt AF, Hunt NB, Gordillo-Maranon M, et al. Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease. Nat Commun. 2021;12(1):5640. This paper provided genetic evidence that CETP is an effective target for CHD prevention but with a potential on-target adverse effect on age-related macular degeneration.

Barter PJ, Caulfield M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. New Engl J Med. 2007;357(21):2109–22.

Article  CAS  PubMed  Google Scholar 

Schwartz GG, Olsson AG, Abt M, et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012;367(22):2089–99.

Article  CAS  PubMed  Google Scholar 

Lincoff AM, Nicholls SJ, Riesmeyer JS, et al. Evacetrapib and cardiovascular outcomes in high-risk vascular disease. N Engl J Med. 2017;376(20):1933–42.

Article  PubMed  Google Scholar 

Group HTRC, Bowman L, Hopewell JC, et al. Effects of anacetrapib in patients with atherosclerotic vascular disease. N Engl J Med. 2017;377(13):1217–27.

Article  Google Scholar 

Larsen LE, Stoekenbroek RM, Kastelein JJP, Holleboom AG. Moving targets: recent advances in lipid-lowering therapies. Arterioscler Thromb Vasc Biol. 2019;39(3):349–59.

Article  CAS  PubMed  Google Scholar 

Tall AR, Yvan-Charvet L, Terasaka N, Pagler T, Wang N. HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis. Cell Metab. 2008;7(5):365–75.

Article  CAS  PubMed  Google Scholar 

Noh S, Mai K, Shaver M, et al. Emerging cholesterol modulators for atherosclerotic cardiovascular disease. Am J Med Sci. 2022;363(5):373–387. This paper reviewed the cholesterol targeting agents, and discussed the clinical trial efficacy as well as their implications for practical use.

Ready JM. Toward a best-in-class inhibitor of cholesteryl ester transfer protein (CETP). J Med Chem. 2021;64(18):13212–4.

Article  CAS  PubMed  Google Scholar 

Inazu A. CETP deficiency and concerns in CETP inhibitor development. In: The HDL Handbook. 2017;23–35.

Manzanares J, Sala F, Gutiérrez MSG, Rueda FN. Biomarkers. Compr Pharmacol. 2022;693–724.

Tall AR, Rader DJ, Kastelein JJP. Macular degeneration and CETP inhibition. JAMA Cardiol. 2022;7(7):774–775. This study gave a worth-considering comment that suggesting that a fully-understood CETP function and inhibitory mechanism at a molecular level is needed.

Sirtori CR, Mombelli G. CETP antagonism versus agonism in cardiovascular prevention and plaque regression. Clinical Lipidology. 2017;4(1):63–78.

Article  Google Scholar 

Zhang L, Yan F, Zhang S, et al. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nat Chem Biol. 2012;8(4):342–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiu X, Mistry A, Ammirati MJ, et al. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat Struct Mol Biol. 2007;14(2):106–13.

Article  PubMed  Google Scholar 

Wetterau JR, Zilversmit DB. A triglyceride and cholesteryl ester transfer protein associated with liver microsomes. J Biol Chem. 1984;259(17):10863–6.

Article  CAS  PubMed  Google Scholar 

Barter PJ, Jones ME. Kinetic studies of the transfer of esterified cholesterol between human plasma low and high density lipoproteins. J Lipid Res. 1980;21(2):238–49.

Article  CAS  PubMed  Google Scholar 

Ihm J, Quinn DM, Busch SJ, Chataing B, Harmony JA. Kinetics of plasma protein-catalyzed exchange of phosphatidylcholine and cholesteryl ester between plasma lipoproteins. J Lipid Res. 1982;23(9):1328–41.

Article  CAS  PubMed  Google Scholar 

Tall A. Plasma lipid transfer proteins. Annu Rev Biochem. 1995;64:235–57.

Article  CAS  PubMed  Google Scholar 

Shrestha S, Wu BJ, Guiney L, Barter PJ, Rye KA. Cholesteryl ester transfer protein and its inhibitors. J Lipid Res. 2018;59(5):772–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Wu H, Huang C, et al. Optimized negative-staining protocol for lipid-protein interactions investigated by electron microscopy. Methods Mol Biol. 2019;2003:163–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Ren G. IPET and FETR: experimental approach for studying molecular structure dynamics by cryo-electron tomography of a single-molecule structure. PLoS One. 2012;7(1):e30249. This study provided images of the CETP interaction to lipoproteins at molecular levels.

Zhai X, Lei D, Zhang M, et al. LoTToR: An algorithm for missing-wedge correction of the low-tilt tomographic 3D reconstruction of a single-molecule structure. Sci Rep. 2020;10(1):10489.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Grooth GJ, Klerkx AH, Stroes ES, Stalenhoef AF, Kastelein JJ, Kuivenhoven JA. A review of CETP and its relation to atherosclerosis. J Lipid Res. 2004;45(11):1967–74.

Article  PubMed  Google Scholar 

Zlotnick A. Viruses and the physics of soft condensed matter. Proc Natl Acad Sci U S A. 2004;101(44):15549–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S-T, Minevich B, Liu J, et al. Protein lattices: structurally designed, dimensionally controlled and biologically active. Nat Commun. 2021;12:3702.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lei D, Yu Y, Kuang YL, Liu J, Krauss RM, Ren G. Single-molecule 3D imaging of human plasma intermediate-density lipoproteins reveals a polyhedral structure. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864(3):260–70.

Article  CAS  PubMed  Google Scholar 

Lei D, Liu J, Liu H, et al. Single-molecule 3D images of “hole-hole” IgG1 homodimers by individual-particle electron tomography. Sci Rep. 2019;9(1):8864.

Article  PubMed  PubMed Central  Google Scholar 

Zhang M, Zhai X, Li J, Albers JJ, Vuletic S, Ren G. Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP). Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(9):1082–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu H, Zhai X, Lei D, et al. An algorithm for enhancing the image contrast of electron tomography. Sci Rep. 2018;8(1):16711.

Article  PubMed  PubMed Central  Google Scholar 

Lei D, Marras AE, Liu J, et al. Three-dimensional structural dynamics of DNA origami Bennett linkages using individual-particle electron tomography. Nat Commun. 2018;9(1):592.