The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease

Research ArticleImmunologyTransplantation Open Access | 10.1172/jci.insight.154440

Erica Dander,1 Paola Vinci,1 Stefania Vetrano,2,3 Camilla Recordati,4,5 Rocco Piazza,6,7 Grazia Fazio,1 Donatella Bardelli,1 Mattia Bugatti,8 Francesca Sozio,8,9 Andrea Piontini,2,3 Sonia Bonanomi,10 Luca Bertola,4,5 Elena Tassistro,11 Maria Grazia Valsecchi,11 Stefano Calza,12 William Vermi,8 Andrea Biondi,1,10,13 Annalisa Del Prete,8,9 Silvano Sozzani,14,15 and Giovanna D’Amico1

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

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1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Vinci, P. in: JCI | PubMed | Google Scholar

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Vetrano, S. in: JCI | PubMed | Google Scholar

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Recordati, C. in: JCI | PubMed | Google Scholar |

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Piazza, R. in: JCI | PubMed | Google Scholar |

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Fazio, G. in: JCI | PubMed | Google Scholar

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Bardelli, D. in: JCI | PubMed | Google Scholar |

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Bugatti, M. in: JCI | PubMed | Google Scholar |

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Sozio, F. in: JCI | PubMed | Google Scholar

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Piontini, A. in: JCI | PubMed | Google Scholar

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Bonanomi, S. in: JCI | PubMed | Google Scholar

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Bertola, L. in: JCI | PubMed | Google Scholar |

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Tassistro, E. in: JCI | PubMed | Google Scholar

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

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1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Calza, S. in: JCI | PubMed | Google Scholar |

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

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1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

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1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Del Prete, A. in: JCI | PubMed | Google Scholar |

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by Sozzani, S. in: JCI | PubMed | Google Scholar |

1Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

2Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Rozzano, Italy.

3Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

4Department of Veterinary Medicine, University of Milan, Lodi, Italy.

5Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milan, Italy.

6Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

7Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy.

8Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

9Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy.

10Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

11Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 center), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

12Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

13School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

14Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy.

15IRCCS Neuromed, Pozzilli, Italy.

Address correspondence to: Giovanna D’Amico, Centro di Ricerca “M. Tettamanti,” Università Milano-Bicocca/Fondazione MBBM, Via Cadore, 20900 Monza, Italy. Phone: 390392336831; Email: giovanna.damico@asst-monza.it.

Authorship note: SS and GD are co–senior authors.

Find articles by D’Amico, G. in: JCI | PubMed | Google Scholar

Authorship note: SS and GD are co–senior authors.

Published March 8, 2023 - More info

Published in Volume 8, Issue 5 on March 8, 2023
JCI Insight. 2023;8(5):e154440. https://doi.org/10.1172/jci.insight.154440.
© 2023 Dander et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Published March 8, 2023 - Version history
Received: August 25, 2021; Accepted: January 23, 2023 View PDF Abstract

Gastrointestinal graft-versus-host disease (GvHD) is a major cause of mortality and morbidity following allogeneic bone marrow transplantation (allo-BMT). Chemerin is a chemotactic protein that recruits leukoc

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