Do Disease-Modifying Anti-rheumatic Drugs and Exercise Therapy Have a Combined Effect on Disease Activity in Patients with RA? A Scoping Review

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69:1580–8.

Article  PubMed  Google Scholar 

Frisell T, Dehlin M, Di Giuseppe D, Feltelius N, Turesson C, Askling J. Comparative effectiveness of abatacept, rituximab, tocilizumab and TNFi biologics in RA: results from the nationwide Swedish register. Rheumatology (Oxford). 2019;58:1367–77.

Article  CAS  Google Scholar 

Smolen JS, Landewé RBM, Bijlsma JWJ, Burmester GR, Dougados M, Kerschbaumer A, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying anti-rheumatic drugs: 2019 update. Ann Rheum Dis. 2020;79:685–99.

Article  CAS  PubMed  Google Scholar 

Sokka T, Häkkinen A, Kautiainen H, et al. Physical inactivity in patients with rheumatoid arthritis: data from twenty-one countries in a cross-sectional, international study. Arthritis Rheum. 2008;59(1):42–50. https://doi.org/10.1002/art.23255.

Article  PubMed  Google Scholar 

Sveaas SH, Smedslund G, Hagen KB, Dagfinrud H. Effect of cardiorespiratory and strength exercises on disease activity in patients with inflammatory rheumatic diseases: a systematic review and meta-analysis. Br J Sports Med. 2017;51(14):1065–72.

Article  PubMed  Google Scholar 

Metsios GS, Koutedakis Y, Veldhuijzen van Zanten JCS, Stavropoulos-Kalinoglou A, Vitalis P, Duda JL, et al. Cardiorespiratory fitness levels and their association with cardiovaxcular profile in patients with rheumatoid arthritis: a cross-sectional study. Rheumatol. 2015;54:2215–2220.

Stavropoulos-Kalinoglou A, Metsios GS, Veldhuijzen van Zanten JJ, Nightingale P, Kitas GD, Koutedakis Y. Individualised aerobic and resistance exercise training improves cardiorespiratory fitness and reduces cardiovascular risk in patients with rheumatoid arthritis. Ann Rheum Dis. 2013;72:1819–25.

Pedersen BL, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev. 2008;88(4):1379–406.

Article  CAS  PubMed  Google Scholar 

Metsios G, Lemmey A. Exercise as medicine in rheumatoid arthritis: effects on function, body composition, and cardiovascular disease risk. J Clin Exerc Physiol. 2015;4(1):14–22.

Article  Google Scholar 

Metsios G, Moe R, Kitas G. Exercise and inflammation. Best Pract Res Clin Rheumatol. 2020;34(2): 101504.

Article  PubMed  Google Scholar 

Coelho M, Oliveira T, Fernandes R. Biochemistry of adipose tissue: an endocrine organ. Arch Med Sci. 2013;9(2):191–200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Summers G, Metsios G, Stavropoulos-Kalinoglou A, Kitas G. Rheumatoid cachexia and cardiovascular disease. Nat Rev Rheumatol. 2010;6(8):445–51.

Article  PubMed  Google Scholar 

Rausch Osthoff AK, Niedermann K, Braun J, Adams J, Brodin N, Dagfinrud H, et al. 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. Ann Rheum Dis. 2018;77:1251–60.

Article  PubMed  Google Scholar 

Agca R, Heslinga SC, Rollefstad S, Heslinga M, McInnes IB, Peters MJL, et al. EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann Rheum Dis. 2017;76:17–28.

Article  CAS  PubMed  Google Scholar 

Metsios GS, Fenton SA, Moe HR, van der Esch M, van Zanten JV, Koutedakis Y, et al. Implementation of physical activity into routine clinical practice in rheumatic musculoskeletal disease: the IMPACT-RMD study protocol and rationale. J Rheumatol. 2020;30:231–6.

Google Scholar 

Mays N, Pope C, Popay J. Systematically reviewing qualitative and quantitative evidence to inform management and policy-making in the health field. J Health Serv Res Policy. 2005;10(1):6–20.

Article  PubMed  Google Scholar 

Levac D, Colquhoun H, O’Brien KK. Scoping studies: advancing the methodology. Implement Sci. 2010;5:69.

Article  PubMed  PubMed Central  Google Scholar 

Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2005;1:19–32.

Article  Google Scholar 

Higgins JPT, Altman DG, Gøtzsche Peter C, Jüni Peter, Moher D, Oxman AD, et al. Cochrane Bias Methods Group. Cochrane Statistical Methods Group. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. Br Med J. 2011;343:d5928–d5928.

De Jong Z, Munneke M, Zwinderman AH, Kroon HM, Jansen A, Ronday KH, et al. Is a long-term high-intensity exercise program effective and safe in patients with rheumatoid arthritis? Results of a randomized controlled trial. Arthritis Rheum. 2003;48(9):2415–24.

Article  PubMed  Google Scholar 

De Jong Z, Munneke M, Zwinderman AH, Kroon HM, Ronday KH, Lems WF, et al. Long term high intensity exercise and damage of small joints in rheumatoid arthritis. Ann Rheum Dis. 2004;63(11):1399–405.

Article  PubMed  PubMed Central  Google Scholar 

Baillet A, Payraud E, Niderprim VA, Nissen MJ, Allenet B, François P, et al. A dynamic exercise programme to improve patients’ disability in rheumatoid arthritis: a prospective randomized controlled trial. Rheumatology (Oxford). 2009;48(4):410–5.

Article  PubMed  Google Scholar 

Häkkinen A, Sokka T, Kotaniemi A, Hannonen P. A randomized two-year study of the effects of dynamic strength training on muscle strength, disease activity, functional capacity, and bone mineral density in early rheumatoid arthritis. Arthritis Rheum. 2001;44(3):515–22.

Article  PubMed  Google Scholar 

Lyngberg KK, Harreby M, Bentzen H, Frost B, Danneskiold-Samsøe B. Elderly rheumatoid arthritis patients on steroid treatment tolerate physical training without an increase in disease activity. Arch Phys Med Rehabil. 1994;75(11):1189–95.

Article  CAS  PubMed  Google Scholar 

Neuberger GB, Aaronson LS, Gajewski B, Embretson SE, Cagle PE, Loudon JK, et al. Predictors of exercise and effects of exercise on symptoms, function, aerobic fitness, and disease outcomes of rheumatoid arthritis. Arthritis Rheum. 2007;57(6):943–52.

Article  PubMed  Google Scholar 

Strasser B, Leeb G, Strehblow C, Schobersberger W, Haber P, Cauza E. The effects of strength and endurance training in patients with rheumatoid arthritis. Clin Rheumatol. 2011;30(5):623–32.

Article  PubMed  Google Scholar 

Siqueira US, Orsini Valente LG, de Mello MT, Szejnfeld VL, Pinheiro MM. Effectiveness of aquatic exercises in women with rheumatoid arthritis: a randomized, controlled, 16-week intervention-The HydRA Trial. Am J Phys Med Rehabil. 2017;96(3):167–75.

Article  PubMed  Google Scholar 

Manning VL, Hurley MV, Scott DL, Coker B, Choy E, Bearne LM. Education, self-management, and upper extremity exercise training in people with rheumatoid arthritis: a randomized controlled trial. Arthritis Care Res (Hoboken). 2014;66(2):217–27.

Article  PubMed  Google Scholar 

Marcora SM, Lemmey AB, Maddison PJ. Can progressive resistance training reverse cachexia in patients with rheumatoid arthritis? Results of a pilot study. J Rheumatol. 2005;32(6):1031–9.

PubMed  Google Scholar 

Metsios GS, Brodin N, Vlieland TPMV, et al. IMPACT-RMD Consortium. Position Statement on exercise dosage in rheumatic and musculoskeletal diseases: the role of the IMPACT-RMD toolkit. Mediterr J Rheumatol. 2021;32(4):378–385.

Hoffmann TC, Glasziou PP, Boutron I, et al. Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ. 2014;348: g168.

Article  Google Scholar 

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