Inflammatory Cytokines Associated with Multiple Sclerosis Directly Induce Alterations of Neuronal Cytoarchitecture in Human Neurons

Allahyari RV, Clark KL, Shepard KA, Garcia ADR. Sonic hedgehog signaling is negatively regulated in reactive astrocytes after forebrain stab injury. Sci Rep [Internet]. Nature Publishing Group; 2019 [cited 2021 Jul 11];9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345977/

Aram J, Francis A, Tanasescu R, Constantinescu CS (2019) Granulocyte-Macrophage Colony-Stimulating Factor as a Therapeutic Target in Multiple Sclerosis. Neurol Ther 8:45

Article  PubMed  Google Scholar 

Arellano G, Acuña E, Reyes LI, Ottum PA, De Sarno P, Villarroel L, et al. Th1 and Th17 Cells and Associated Cytokines Discriminate among Clinically Isolated Syndrome and Multiple Sclerosis Phenotypes. Front Immunol [Internet]. Frontiers; 2017 [cited 2021 Jul 11];8. Available from: https://www.frontiersin.org/articles/https://doi.org/10.3389/fimmu.2017.00753/full

Erika A. Bach, Aguet M, Schreiber RD. THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling [Internet]. http://dx.doi.org/https://doi.org/10.1146/annurev.immunol.15.1.563. Annual Reviews 4139 El Camino Way, P.O. Box 10139, Palo Alto, CA 94303–0139, USA; 2003 [cited 2021 Jul 11]. Available from:https://www.annualreviews.org/doi/abs/https://doi.org/10.1146/annurev.immunol.15.1.563

Beringer A, Thiam N, Molle J, Bartosch B, Miossec P (2018) Synergistic effect of interleukin-17 and tumour necrosis factor-α on inflammatory response in hepatocytes through interleukin-6-dependent and independent pathways. Clin Exp Immunol 193:221

Article  CAS  PubMed  PubMed Central  Google Scholar 

Briscoe J, Thérond PP (2013) The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol 14:416–29

Article  PubMed  Google Scholar 

Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK et al (1996) Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2:788–794

Article  CAS  PubMed  Google Scholar 

Bühler U, Fleischer V, Luessi F, Rezk A, Belikan P, Graetz C et al (2017) Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment. Mult Scler 23:567–576

Article  PubMed  Google Scholar 

Caccamo D, Katsetos CD, Herman MM, Frankfurter A, Collins VP, Rubinstein LJ. Immunohistochemistry of a spontaneous murine ovarian teratoma with neuroepithelial differentiation. Neuron-associated beta-tubulin as a marker for primitive neuroepithelium. Lab Investig J Tech Methods Pathol [Internet]. Lab Invest; 1989 [cited 2021 Jul 6];60. Available from: https://pubmed.ncbi.nlm.nih.gov/2467076/

Carrieri PB, Provitera V, Rosa TD, Tartaglia G, Gorga F, Perrella O. Profile of Cerebrospinal Fluid and Serum Cytokines in Patients with Relapsing-Remitting Multiple Sclerosis. A Correlation with Clinical Activity. Immunopharmacol Immunotoxicol [Internet]. Taylor & Francis; 2008 [cited 2021 Jul 5]; Available from: https://www.tandfonline.com/doi/abs/https://doi.org/10.3109/08923979809034820

Chen G, Goeddel DV (2002) TNF-R1 signaling: a beautiful pathway. Science 296:1634–1635

Article  CAS  PubMed  Google Scholar 

Chen H, Lin W, Zhang Y, Lin L, Chen J, Zeng Y et al (2016) IL-10 Promotes Neurite Outgrowth and Synapse Formation in Cultured Cortical Neurons after the Oxygen-Glucose Deprivation via JAK1/STAT3 Pathway. Sci Rep 6:1–16

Google Scholar 

Couper KN, Blount DG, Riley EM (2008) IL-10: The Master Regulator of Immunity to Infection. J Immunol Am 180:5771–5777

Article  CAS  Google Scholar 

Das Sarma J, Ciric B, Marek R, Sadhukhan S, Caruso ML, Shafagh J et al (2009) Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis. J Neuroinflamm 6:14

Article  Google Scholar 

Dikmen HO, Hemmerich M, Lewen A, Hollnagel J-O, Chausse B, Kann O (2020) GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ. J Neuroinflamm 17:1–13

Article  Google Scholar 

Downen M, Amaral TD, Hua LL, Zhao ML, Lee SC (1999) Neuronal death in cytokine-activated primary human brain cell culture: role of tumor necrosis factor-alpha. Glia 28:114–127

Article  CAS  PubMed  Google Scholar 

Engelhardt KR, Grimbacher B (2014) IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms. Curr Top Microbiol Immunol 380:1–18. https://doi.org/10.1007/978-3-662-43492-5_1

Friese MA, Montalban X, Willcox N, Bell JI, Martin R, Fugger L (2006) The value of animal models for drug development in multiple sclerosis. Brain J Neurol 129:1940–1952

Article  Google Scholar 

Gregory AP, Dendrou CA, Attfield KE, Haghikia A, Xifara DK, Butter F et al (2012) TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature 488:508–511

Article  CAS  PubMed  PubMed Central  Google Scholar 

Havrdová E, Belova A, Goloborodko A, Tisserant A, Wright A, Wallstroem E et al (2016) Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study. J Neurol 263:1287–1295

Article  PubMed  Google Scholar 

Hedegaard CJ, Krakauer M, Bendtzen K, Lund H, Sellebjerg F, Nielsen CH (2008) T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. Immunology 125:161

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huppert J, Closhen D, Croxford A, White R, Kulig P, Pietrowski E et al (2010) Cellular mechanisms of IL-17-induced blood-brain barrier disruption. FASEB J 24:1023–34

Article  CAS  PubMed  Google Scholar 

Imitola J, Rasouli J, Watanabe F, Mahajan K, Sharan AD, Ciric B et al (2018) Elevated expression of granulocyte-macrophage colony-stimulating factor receptor in multiple sclerosis lesions. J Neuroimmunol 317:45–54

Article  CAS  PubMed  Google Scholar 

Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y et al (2009) Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses. Immunity 30:108–119

Article  CAS  PubMed  Google Scholar 

Jäckle K, Zeis T, Schaeren-Wiemers N, Junker A, van der Meer F, Kramann N et al (2020) Molecular signature of slowly expanding lesions in progressive multiple sclerosis. Brain 143:2073–2088

Article  PubMed  Google Scholar 

Kang Z, Wang C, Zepp J, Wu L, Sun K, Zhao J et al (2013) Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells. Nat Neurosci 16:1401

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M et al (2007) Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 13:1173–1175

Article  CAS  PubMed  PubMed Central  Google Scholar 

Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells [Internet]. https://doi.org/10.1146/annurev.immunol.021908.132710. Annual Reviews; 2009 [cited 2021 Jul 11]. Available from: https://www.annualreviews.org/doi/abs/https://doi.org/10.1146/annurev.immunol.021908.132710

Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K et al (2007) Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F. J Immunol Baltim Md 1950 179:5462

CAS  Google Scholar 

Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD et al (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201:233–240

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, DeFea K et al (2008) Differential Regulation of Chemokines by IL-17 in Colonic Epithelial Cells. J Immunol 181:6536–6545

Article  CAS  PubMed  Google Scholar 

Liang SC, Tan X-Y, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M et al (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203:2271

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu L, Geisert EE, Frankfurter A, Spano AJ, Jiang CX, Yue J et al (2007) A transgenic mouse Class-III β tubulin reporter using yellow fluorescent protein. Genesis 45:560–9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H et al (2002) Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 8:500–508

Article  CAS  PubMed  Google Scholar 

Loos J, Schmaul S, Noll TM, Paterka M, Schillner M, Löffel JT et al (2020) Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy. J Neuroinflamm 17:1–12

Article  Google Scholar 

Lopez-Bergami P, Barbero G (2020) The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment. Cancer Metastasis Rev 39:933–952

Article  CAS  PubMed  Google Scholar 

Lotfi N, Thome R, Rezaei N, Zhang G-X, Rezaei A, Rostami A, et al. Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update. Front Immunol [Internet]. Frontiers; 2019 [cited 2021 Jul 11];10. Available from: https://www.frontiersin.org/articles/https://doi.org/10.3389/fimmu.2019.01265/full

Luo H, Liu H-Z, Zhang W-W, Matsuda M, Lv N, Chen G et al (2019) Interleukin-17 Regulates Neuron-Glial Communications, Synaptic Transmission, and Neuropathic Pain after Chemotherapy. Cell Rep 29:2384-2397.e5

Article  CAS  PubMed  Google Scholar 

Ly K, Smith MP, Thibodeaux Q, Reddy V, Liao W, Bhutani T. Anti IL-17 in psoriasis. Expert Rev Clin Immunol [Internet]. Taylor & Francis; 2019 [cited 2021 Jul 11]; Available from: https://www.tandfonline.com/doi/abs/https://doi.org/10.1080/1744666X.2020.1679625

Machado-Santos J, Saji E, Tröscher AR, Paunovic M, Liblau R, Gabriely G et al (2018) The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells. Brain Oxford Academic 141:2066–2082

Google Scholar 

Maimone D, Gregory S, Arnason BGW, Reder AT (1991) Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J Neuroimmunol 32:67–74

Article  CAS  PubMed  Google Scholar 

Mariani M, Karki R, Spennato M, Pandya D, He S, Andreoli M et al (2015) Class III β-tubulin in Normal and Cancer tissues. Gene 563:109

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mizuno T, Zhang G, Takeuchi H, Kawanokuchi J, Wang J, Sonobe Y et al (2008) Interferon-γ directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN-γ receptor and AMPA GluRl receptor. FASEB J 22:1797–806

Article  CAS  PubMed  Google Scholar 

Moore KW, Malefyt R de W, Coffman RL, O’Garra A. Interleukin-10 and the Interleukin-10 Receptor [Internet]. https://doi.org/10.1146/annurev.immunol.19.1.683. Annual Reviews 4139 El Camino Way, P.O. Box 10139, Palo Alto, CA 94303–0139, USA; 2003 [cited 2021 Jul 11]. Available from: https://www.annualreviews.org/doi/abs/https://doi.org/10.1146/annurev.immunol.19.1.683

Nasiri E, Sankowski R, Dietrich H, Oikonomidi A, Huerta PT, Popp J, et al. Key role of MIF-related neuroinflammation in neurodegeneration and cognitive impairment in Alzheimer’s disease. Mol Med [Internet]. The Feinstein Institute for Medical Research; 2020 [cited 2021 Jul 6];26. Available from: https://www.ncbi.nlm.nih.gov/pmc/

留言 (0)

沒有登入
gif