Temporal control of neuronal wiring

ElsevierVolume 142, June 2023, Pages 81-90Seminars in Cell & Developmental BiologyAuthor links open overlay panel, Abstract

Wiring an animal brain is a complex process involving a staggering number of cell-types born at different times and locations in the developing brain. Incorporation of these cells into precise circuits with high fidelity is critical for animal survival and behavior. Assembly of neuronal circuits is heavily dependent upon proper timing of wiring programs, requiring neurons to express specific sets of genes (sometimes transiently) at the right time in development. While cell-type specificity of genetic programs regulating wiring has been studied in detail, mechanisms regulating proper timing and coordination of these programs across cell-types are only just beginning to emerge. In this review, we discuss some temporal regulators of wiring programs and how their activity is controlled over time and space. A common feature emerges from these temporal regulators - they are induced by cell-extrinsic cues and control transcription factors capable of regulating a highly cell-type specific set of target genes. Target specificity in these contexts comes from cell-type specific transcription factors. We propose that the spatiotemporal specificity of wiring programs is controlled by the combinatorial activity of temporal programs and cell-type specific transcription factors. Going forward, a better understanding of temporal regulators will be key to understanding the mechanisms underlying brain wiring, and will be critical for the development of in vitro models like brain organoids.

AbbreviationsC. elegans

Caenorhabditis elegans

scRNA-Seq

single-cell Ribonucleic Acid sequencing

Syg

synaptogenesis abnormal

N-Cadherin

Neural Cadherin

S1

Primary somatosensory cortex

SynGAP

Synaptic Ras GTPase activating protein

Ftz-f1

Fushi tarazu transcription factor 1

ERE

Estrogen response element

Npas4

Neuronal PAS domain protein 4

BDNF

Brain-derived neurotrophic factor

Frmpd3

FERM And PDZ Domain Containing 3

Igsf9b

Immunoglobulin Superfamily Member 9B

OSN

Olfactory sensory neuron

TGF-β

Transforming growth factor beta

NF- κB

Nuclear factor kappa B

NCAM

Neural cell adhesion molecule

dpr

defective proboscis response

ATAC-Seq

Assay for transposase accessible chromatin with high-throughput sequencing

Keywords

Neurodevelopment

Brain wiring

Transcriptional control

Temporal specificity

Hormones

Neuronal activity

© 2022 The Author(s). Published by Elsevier Ltd.

留言 (0)

沒有登入
gif