Sperm capacitation and transcripts levels are altered by in vitro THC exposure

Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, Regional, and global Trends in Infertility Prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med. 2012;9:e1001356.

Article  PubMed  PubMed Central  Google Scholar 

Pfeifer S, Butts S, Dumesic D, et al. Diagnostic evaluation of the infertile male: a committee opinion. Fertil Steril. 2015;103:e18–e25.

Article  Google Scholar 

Canadian Alcohol and Drugs Survey (CADS). : summary of results for 2019 - Canada.ca. https://www.canada.ca/en/health-canada/services/canadian-alcohol-drugs-survey/2019-summary.html#a4. Accessed 19 May 2022

Substance Abuse and Mental Health Services Administration. (2020) Key substance use and mental health indicators in the United States: Results from the 2019 National Survey on Drug Use and Health. Rockville, MD

Greaves L, Hemsing N. Sex and gender interactions on the Use and Impact of recreational Cannabis. Int J Environ Res Public Health 2020. 2020;17:509.

CAS  Google Scholar 

Hemsing N, Greaves L. Gender norms, roles and relations and Cannabis-use patterns: a scoping review. Int J Environ Res Public Health 2020. 2020;17:947.

Google Scholar 

Canadian Cannabis Survey 2021: Summary - Canada.ca. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/research-data/canadian-cannabis-survey-2021-summary.html. Accessed 19 May 2022

Amin MR, Ali DW. Pharmacology of Medical Cannabis. Adv Exp Med Biol. 2019;1162:151–65.

Article  CAS  PubMed  Google Scholar 

Wade DT, Collin C, Stott C, Duncombe P. Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Mult Scler. 2010;16:707–14.

Article  CAS  PubMed  Google Scholar 

Maroon J, Bost J. Review of the neurological benefits of phytocannabinoids. Surg Neurol Int. 2018. https://doi.org/10.4103/SNI.SNI_45_18.

Article  PubMed  PubMed Central  Google Scholar 

Boehnke KF, Dean O, Haffajee RL, Hosanagar A. (2022) U.S. Trends in Registration for Medical Cannabis and Reasons for Use From 2016 to 2020. https://doi.org/107326/M22-0217. https://doi.org/10.7326/M22-0217

Maccarrone M, Rapino C, Francavilla F, Barbonetti A. (2020) Cannabinoid signalling and effects of cannabis on the male reproductive system. Nature Reviews Urology 2020 18:1 18:19–32

Gaoni Y, Mechoulam R. Isolation, structure, and partial synthesis of an active constituent of Hashish. J Am Chem Soc. 1964;86:1646–7.

Article  CAS  Google Scholar 

Hively RL, Mosher WA, Hoffmann FW. Isolation of trans-∆6-Tetrahydrocannabinol from Marijuana. J Am Chem Soc. 1966;88:1832–3.

Article  CAS  PubMed  Google Scholar 

la Maida N, di Giorgi A, Pichini S, Busardò FP, Huestis MA. Recent challenges and trends in forensic analysis: ∆9-THC isomers pharmacology, toxicology and analysis. J Pharm Biomed Anal. 2022;220:114987.

Article  PubMed  Google Scholar 

ElSohly MA, Chandra S, Radwan M, Majumdar CG, Church JC. A Comprehensive Review of Cannabis Potency in the United States in the last decade. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021;6:603–6.

PubMed  Google Scholar 

ElSohly MA, Mehmedic Z, Foster S, Gon C, Chandra S, Church JC. Changes in Cannabis Potency over the last 2 decades (1995–2014): analysis of Current Data in the United States. Biol Psychiatry. 2016;79:613–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pertwee RG, Howlett AC, Abood ME, et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2. Pharmacol Rev. 2010;62:588–631.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meccariello R, Battista N, Bradshaw HB, Wang H. (2014) Updates in Reproduction Coming from the Endocannabinoid System. Int J Endocrinol 2014:412354

Devane WA, Hanuš L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 1992;258:1946–9.

Article  CAS  PubMed  Google Scholar 

Lewis SEM, Rapino C, di Tommaso M, Pucci M, Battista N, Paro R, Simon L, Lutton D, Maccarrone M. Differences in the endocannabinoid system of sperm from fertile and infertile men. PLoS ONE. 2012. https://doi.org/10.1371/JOURNAL.PONE.0047704.

Article  PubMed  PubMed Central  Google Scholar 

Pertwee RG. Endocannabinoids and their pharmacological actions. Handb Exp Pharmacol. 2015;231:1–37.

Article  CAS  PubMed  Google Scholar 

Rossato M, Popa FI, Ferigo M, Clari G, Foresta C. Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function. J Clin Endocrinol Metab. 2005;90:984–91.

Article  CAS  PubMed  Google Scholar 

Francou MM, Girela JL, de Juan A, Ten J, Bernabeu R, de Juan J. Human sperm motility, capacitation and acrosome reaction are impaired by 2-arachidonoylglycerol endocannabinoid. Histol Histopathol. 2017;32:1351–8.

CAS  PubMed  Google Scholar 

Pertwee RG. Pharmacological actions of cannabinoids. Handb Exp Pharmacol. 2005;168:1–51.

Article  CAS  Google Scholar 

Amoako AA, Marczylo TH, Marczylo EL, Elson J, Willets JM, Taylor AH, Konje JC. Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia. Hum Reprod. 2013;28:2058–66.

Article  CAS  PubMed  Google Scholar 

Maccarrone M, Wenger T. Effects of cannabinoids on hypothalamic and reproductive function. Handb Exp Pharmacol. 2005;168:555–71.

Article  CAS  Google Scholar 

Agirregoitia E, Carracedo A, Subirán N, Valdivia A, Agirregoitia N, Peralta L, Velasco G, Irazusta J. The CB2 cannabinoid receptor regulates human sperm cell motility. Fertil Steril. 2010;93:1378–87.

Article  CAS  PubMed  Google Scholar 

Kolodny RC, Masters WH, Kolodner RM, Toro G. Depression of plasma testosterone levels after chronic intensive marihuana use. N Engl J Med. 1974;290:872–4.

Article  CAS  PubMed  Google Scholar 

Banerjee A, Singh A, Srivastava P, Turner H, Krishna A. Effects of chronic bhang (cannabis) administration on the reproductive system of male mice. Birth Defects Res B Dev Reprod Toxicol. 2011;92:195–205.

Article  CAS  PubMed  Google Scholar 

Gundersen TD, Jørgensen N, Andersson AM, Bang AK, Nordkap L, Skakkebæk NE, Priskorn L, Juul A, Jensen TK. Association between Use of Marijuana and Male Reproductive Hormones and Semen Quality: a study among 1,215 healthy Young Men. Am J Epidemiol. 2015;182:473–81.

Article  PubMed  Google Scholar 

Murphy SK, Itchon-Ramos N, Visco Z, et al. Cannabinoid exposure and altered DNA methylation in rat and human sperm. Epigenetics. 2018;13:1208–21.

Article  PubMed  PubMed Central  Google Scholar 

Pacey AA, Povey AC, Clyma JA, McNamee R, Moore HD, Baillie H, Cherry NM. Modifiable and non-modifiable risk factors for poor sperm morphology. Hum Reprod. 2014;29:1629–36.

Article  PubMed  Google Scholar 

Carroll K, Pottinger AM, Wynter S, DaCosta V. Marijuana use and its influence on sperm morphology and motility: identified risk for fertility among jamaican men. Andrology. 2020;8:136–42.

Article  CAS  PubMed  Google Scholar 

Menkveld R, Holleboom CAG, Rhemrev JPT. Measurement and significance of sperm morphology. Asian J Androl. 2011;13:59.

Article  PubMed  Google Scholar 

García-Vázquez F, Gadea J, Matás C, Holt W. Importance of sperm morphology during sperm transport and fertilization in mammals. Asian J Androl. 2016;18:844–50.

Article  PubMed  PubMed Central  Google Scholar 

Schrott R, Acharya K, Itchon-Ramos N, Hawkey AB, Pippen E, Mitchell JT, Kollins SH, Levin ED, Murphy SK. Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm. Epigenetics. 2020;15:161–73.

Article  PubMed  Google Scholar 

Schrott R, Modliszewski JL, Hawkey AB, Grenier C, Holloway Z, Evans J, Pippen E, Corcoran DL, Levin ED, Murphy SK. Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring. Epigenetics Chromatin. 2022;15:1–15.

Article  Google Scholar 

Slotkin TA, Skavicus S, Levin ED, Seidler FJ. Paternal ∆9-Tetrahydrocannabinol exposure prior to mating elicits deficits in Cholinergic synaptic function in the offspring. Toxicol Sci. 2020;174:210–7.

Article  CAS  PubMed  Google Scholar 

Holloway ZR, Hawkey AB, Pippin E, White H, Wells C, Kenou B, Rezvani AH, Murphy SK, Levin ED. Paternal factors in neurodevelopmental toxicology: THC exposure of male rats causes long-lasting neurobehavioral effects in their offspring. Neurotoxicology. 2020;78:57–63.

Article  CAS  PubMed  Google Scholar 

Whan LB, West MCL, Mcclure N, Lewis SEM. Effects of delta-9-tetrahydrocannabinol, the primary psychoactive cannabinoid in marijuana, on human sperm function in vitro. Fertil Steril. 2006;85:653–60.

Article  CAS  PubMed  Google Scholar 

FDA. (2004) MARINOL ® (Dronabinol).

Fagerlind M, Stålhammar H, Olsson B, Klinga-Levan K. Expression of miRNAs in Bull Spermatozoa correlates with Fertility Rates. Reprod Domest Anim. 2015;50:587–94.

Article  CAS  PubMed  Google Scholar 

Lambard S, Galeraud-Denis I, Martin G, Levy R, Chocat A, Carreau S. Analysis and significance of mRNA in human ejaculated sperm from normozoospermic donors: relationship to sperm motility and capacitation. Mol Hum Reprod. 2004;10:535–41.

Article  CAS  PubMed 

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