Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, Regional, and global Trends in Infertility Prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med. 2012;9:e1001356.
Article PubMed PubMed Central Google Scholar
Pfeifer S, Butts S, Dumesic D, et al. Diagnostic evaluation of the infertile male: a committee opinion. Fertil Steril. 2015;103:e18–e25.
Canadian Alcohol and Drugs Survey (CADS). : summary of results for 2019 - Canada.ca. https://www.canada.ca/en/health-canada/services/canadian-alcohol-drugs-survey/2019-summary.html#a4. Accessed 19 May 2022
Substance Abuse and Mental Health Services Administration. (2020) Key substance use and mental health indicators in the United States: Results from the 2019 National Survey on Drug Use and Health. Rockville, MD
Greaves L, Hemsing N. Sex and gender interactions on the Use and Impact of recreational Cannabis. Int J Environ Res Public Health 2020. 2020;17:509.
Hemsing N, Greaves L. Gender norms, roles and relations and Cannabis-use patterns: a scoping review. Int J Environ Res Public Health 2020. 2020;17:947.
Canadian Cannabis Survey 2021: Summary - Canada.ca. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/research-data/canadian-cannabis-survey-2021-summary.html. Accessed 19 May 2022
Amin MR, Ali DW. Pharmacology of Medical Cannabis. Adv Exp Med Biol. 2019;1162:151–65.
Article CAS PubMed Google Scholar
Wade DT, Collin C, Stott C, Duncombe P. Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Mult Scler. 2010;16:707–14.
Article CAS PubMed Google Scholar
Maroon J, Bost J. Review of the neurological benefits of phytocannabinoids. Surg Neurol Int. 2018. https://doi.org/10.4103/SNI.SNI_45_18.
Article PubMed PubMed Central Google Scholar
Boehnke KF, Dean O, Haffajee RL, Hosanagar A. (2022) U.S. Trends in Registration for Medical Cannabis and Reasons for Use From 2016 to 2020. https://doi.org/107326/M22-0217. https://doi.org/10.7326/M22-0217
Maccarrone M, Rapino C, Francavilla F, Barbonetti A. (2020) Cannabinoid signalling and effects of cannabis on the male reproductive system. Nature Reviews Urology 2020 18:1 18:19–32
Gaoni Y, Mechoulam R. Isolation, structure, and partial synthesis of an active constituent of Hashish. J Am Chem Soc. 1964;86:1646–7.
Hively RL, Mosher WA, Hoffmann FW. Isolation of trans-∆6-Tetrahydrocannabinol from Marijuana. J Am Chem Soc. 1966;88:1832–3.
Article CAS PubMed Google Scholar
la Maida N, di Giorgi A, Pichini S, Busardò FP, Huestis MA. Recent challenges and trends in forensic analysis: ∆9-THC isomers pharmacology, toxicology and analysis. J Pharm Biomed Anal. 2022;220:114987.
ElSohly MA, Chandra S, Radwan M, Majumdar CG, Church JC. A Comprehensive Review of Cannabis Potency in the United States in the last decade. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021;6:603–6.
ElSohly MA, Mehmedic Z, Foster S, Gon C, Chandra S, Church JC. Changes in Cannabis Potency over the last 2 decades (1995–2014): analysis of Current Data in the United States. Biol Psychiatry. 2016;79:613–9.
Article CAS PubMed PubMed Central Google Scholar
Pertwee RG, Howlett AC, Abood ME, et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2. Pharmacol Rev. 2010;62:588–631.
Article CAS PubMed PubMed Central Google Scholar
Meccariello R, Battista N, Bradshaw HB, Wang H. (2014) Updates in Reproduction Coming from the Endocannabinoid System. Int J Endocrinol 2014:412354
Devane WA, Hanuš L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 1992;258:1946–9.
Article CAS PubMed Google Scholar
Lewis SEM, Rapino C, di Tommaso M, Pucci M, Battista N, Paro R, Simon L, Lutton D, Maccarrone M. Differences in the endocannabinoid system of sperm from fertile and infertile men. PLoS ONE. 2012. https://doi.org/10.1371/JOURNAL.PONE.0047704.
Article PubMed PubMed Central Google Scholar
Pertwee RG. Endocannabinoids and their pharmacological actions. Handb Exp Pharmacol. 2015;231:1–37.
Article CAS PubMed Google Scholar
Rossato M, Popa FI, Ferigo M, Clari G, Foresta C. Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function. J Clin Endocrinol Metab. 2005;90:984–91.
Article CAS PubMed Google Scholar
Francou MM, Girela JL, de Juan A, Ten J, Bernabeu R, de Juan J. Human sperm motility, capacitation and acrosome reaction are impaired by 2-arachidonoylglycerol endocannabinoid. Histol Histopathol. 2017;32:1351–8.
Pertwee RG. Pharmacological actions of cannabinoids. Handb Exp Pharmacol. 2005;168:1–51.
Amoako AA, Marczylo TH, Marczylo EL, Elson J, Willets JM, Taylor AH, Konje JC. Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia. Hum Reprod. 2013;28:2058–66.
Article CAS PubMed Google Scholar
Maccarrone M, Wenger T. Effects of cannabinoids on hypothalamic and reproductive function. Handb Exp Pharmacol. 2005;168:555–71.
Agirregoitia E, Carracedo A, Subirán N, Valdivia A, Agirregoitia N, Peralta L, Velasco G, Irazusta J. The CB2 cannabinoid receptor regulates human sperm cell motility. Fertil Steril. 2010;93:1378–87.
Article CAS PubMed Google Scholar
Kolodny RC, Masters WH, Kolodner RM, Toro G. Depression of plasma testosterone levels after chronic intensive marihuana use. N Engl J Med. 1974;290:872–4.
Article CAS PubMed Google Scholar
Banerjee A, Singh A, Srivastava P, Turner H, Krishna A. Effects of chronic bhang (cannabis) administration on the reproductive system of male mice. Birth Defects Res B Dev Reprod Toxicol. 2011;92:195–205.
Article CAS PubMed Google Scholar
Gundersen TD, Jørgensen N, Andersson AM, Bang AK, Nordkap L, Skakkebæk NE, Priskorn L, Juul A, Jensen TK. Association between Use of Marijuana and Male Reproductive Hormones and Semen Quality: a study among 1,215 healthy Young Men. Am J Epidemiol. 2015;182:473–81.
Murphy SK, Itchon-Ramos N, Visco Z, et al. Cannabinoid exposure and altered DNA methylation in rat and human sperm. Epigenetics. 2018;13:1208–21.
Article PubMed PubMed Central Google Scholar
Pacey AA, Povey AC, Clyma JA, McNamee R, Moore HD, Baillie H, Cherry NM. Modifiable and non-modifiable risk factors for poor sperm morphology. Hum Reprod. 2014;29:1629–36.
Carroll K, Pottinger AM, Wynter S, DaCosta V. Marijuana use and its influence on sperm morphology and motility: identified risk for fertility among jamaican men. Andrology. 2020;8:136–42.
Article CAS PubMed Google Scholar
Menkveld R, Holleboom CAG, Rhemrev JPT. Measurement and significance of sperm morphology. Asian J Androl. 2011;13:59.
García-Vázquez F, Gadea J, Matás C, Holt W. Importance of sperm morphology during sperm transport and fertilization in mammals. Asian J Androl. 2016;18:844–50.
Article PubMed PubMed Central Google Scholar
Schrott R, Acharya K, Itchon-Ramos N, Hawkey AB, Pippen E, Mitchell JT, Kollins SH, Levin ED, Murphy SK. Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm. Epigenetics. 2020;15:161–73.
Schrott R, Modliszewski JL, Hawkey AB, Grenier C, Holloway Z, Evans J, Pippen E, Corcoran DL, Levin ED, Murphy SK. Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring. Epigenetics Chromatin. 2022;15:1–15.
Slotkin TA, Skavicus S, Levin ED, Seidler FJ. Paternal ∆9-Tetrahydrocannabinol exposure prior to mating elicits deficits in Cholinergic synaptic function in the offspring. Toxicol Sci. 2020;174:210–7.
Article CAS PubMed Google Scholar
Holloway ZR, Hawkey AB, Pippin E, White H, Wells C, Kenou B, Rezvani AH, Murphy SK, Levin ED. Paternal factors in neurodevelopmental toxicology: THC exposure of male rats causes long-lasting neurobehavioral effects in their offspring. Neurotoxicology. 2020;78:57–63.
Article CAS PubMed Google Scholar
Whan LB, West MCL, Mcclure N, Lewis SEM. Effects of delta-9-tetrahydrocannabinol, the primary psychoactive cannabinoid in marijuana, on human sperm function in vitro. Fertil Steril. 2006;85:653–60.
Article CAS PubMed Google Scholar
FDA. (2004) MARINOL ® (Dronabinol).
Fagerlind M, Stålhammar H, Olsson B, Klinga-Levan K. Expression of miRNAs in Bull Spermatozoa correlates with Fertility Rates. Reprod Domest Anim. 2015;50:587–94.
Article CAS PubMed Google Scholar
Lambard S, Galeraud-Denis I, Martin G, Levy R, Chocat A, Carreau S. Analysis and significance of mRNA in human ejaculated sperm from normozoospermic donors: relationship to sperm motility and capacitation. Mol Hum Reprod. 2004;10:535–41.
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