COVID-19 disease is associated with higher morbidity and mortality in cancer patients. SerOzNET is a prospective cohort study of adults and children with cancer undergoing routine SARS-CoV-2 vaccination in Australia. Peripheral blood was collected and processed at multiple points (one pre-vaccination and five or more post-vaccination) to address the primary aim of the study to assess the serological and immunological responses to vaccination. A secondary aim of the study was to document patient response to vaccination using qualitative measures, including patient-reported outcomes, vaccine hesitancy survey and post-hoc toxicity recording (body, et al.,2022). This statistical analysis plan describes the analysis of the data collected to address this aim. We will refer to this as the SerOzNET QoL Substudy.

The authors have declared no competing interest.

https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-07019-1

This study was partially funded by Cancer Australia, Victorian Cancer Agency and The Leukaemia Foundation (Australia)

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Monash Human Research and Ethics Committee gave ethical approval for this work.

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All data produced in the present study are available upon reasonable request to the authors.