Abe S, Okumura A, Fujii T, Someya T, Tadokoro R, Arai Y, Nakazawa T, Yamashiro Y. Sepsis associated encephalopathy in an infant with biliary atresia. Brain Dev. 2008;30(8):544–7. https://doi.org/10.1016/j.braindev.2007.12.015. (Epub 2008 Apr 18 PMID: 18423924).

Article  PubMed  Google Scholar 

Alexander JJ, Jacob A, Cunningham P, Hensley L, Quigg RJ. TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1. Neurochem Int. 2008;52(3):447–56. https://doi.org/10.1016/j.neuint.2007.08.006. (Epub 2007 Aug 17. PMID: 17884256; PMCID: PMC3191465).

Article  CAS  PubMed  Google Scholar 

Algebaly H, ElSherbini S, Galal A, Hamdi R, Baz A, Elbeleidy A. Transcranial Doppler can predict development and outcome of sepsis-associated encephalopathy in pediatrics with severe sepsis or septic shock. Front Pediatr. 2020;20(8):450. https://doi.org/10.3389/fped.2020.00450. (PMID: 32974238; PMCID: PMC7468380).

Article  Google Scholar 

Andonegui G, Zelinski EL, Schubert CL, Knight D, Craig LA, Winston BW, Spanswick SC, Petri B, Jenne CN, Sutherland JC, Nguyen R, Jayawardena N, Kelly MM, Doig CJ, Sutherland RJ, Kubes P. Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment. JCI Insight. 2018;3(9):e99364. https://doi.org/10.1172/jci.insight.99364. (PMID: 29720578; PMCID: PMC6012517).

Article  PubMed  PubMed Central  Google Scholar 

Archie SR, Al Shoyaib A, Cucullo L. Blood-brain barrier dysfunction in CNS disorders and putative therapeutic targets: an overview. Pharmaceutics. 2021;13(11):1779. https://doi.org/10.3390/pharmaceutics13111779. (PMID: 34834200; PMCID: PMC8622070).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arslan D, Ekinci A, Arici A, Bozdemir E, Akil E, Ozdemir HH. Effects of Ecballium elaterium on brain in a rat model of sepsis-associated encephalopathy. Libyan J Med. 2017;12(1):1369834. https://doi.org/10.1080/19932820.2017.1369834. (PMID:28859554;PMCID:PMC5650042).

Article  PubMed  PubMed Central  Google Scholar 

Banks WA, Gray AM, Erickson MA, Salameh TS, Damodarasamy M, Sheibani N, Meabon JS, Wing EE, Morofuji Y, Cook DG, Reed MJ. Lipopolysaccharide-induced blood–brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit. J Neuroinflamm. 2015;25(12):223. https://doi.org/10.1186/s12974-015-0434-1. (PMID: 26608623; PMCID: PMC4660627).

Article  CAS  Google Scholar 

Barbosa-Silva MC, Lima MN, Battaglini D, Robba C, Pelosi P, Rocco PRM, Maron-Gutierrez T. Infectious disease-associated encephalopathies. Crit Care. 2021;25(1):236. https://doi.org/10.1186/s13054-021-03659-6. (PMID: 34229735; PMCID: PMC8259088).

Article  PubMed  PubMed Central  Google Scholar 

Bartha AI, Foster-Barber A, Miller SP, Vigneron DB, Glidden DV, Barkovich AJ, Ferriero DM. Neonatal encephalopathy: association of cytokines with MR spectroscopy and outcome. Pediatr Res. 2004;56(6):960–6. https://doi.org/10.1203/01.PDR.0000144819.45689.BB. (Epub 2004 Oct 20 PMID: 15496611).

Article  CAS  PubMed  Google Scholar 

Becker AE, Teixeira SR, Lunig NA, Mondal A, Fitzgerald JC, Topjian AA, Weiss SL, Griffis H, Schramm SE, Traynor DM, Vossough A, Kirschen MP. Sepsis-related brain MRI abnormalities are associated with mortality and poor neurological outcome in pediatric sepsis. Pediatr Neurol. 2021;128:1–8. https://doi.org/10.1016/j.pediatrneurol.2021.12.001. (Epub ahead of print. PMID: 34992035).

Article  PubMed  Google Scholar 

Bedirli N, Bagriacik EU, Yilmaz G, Ozkose Z, Kavutçu M, CavuntBayraktar A, Bedirli A. Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis. J Int Med Res. 2018;46(7):2828–42. https://doi.org/10.1177/0300060518773265. (PMID: 29756489; PMCID: PMC6124281).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bi W, Lan X, Zhang J, Xiao S, Cheng X, Wang H, Lu D, Zhu L. USP8 ameliorates cognitive and motor impairments via microglial inhibition in a mouse model of sepsis-associated encephalopathy. Brain Res. 2019;15(1719):40–8. https://doi.org/10.1016/j.brainres.2019.05.009. (Epub 2019 May 7 PMID: 31075263).

Article  CAS  Google Scholar 

Blom C, Deller BL, Fraser DD, Patterson EK, Martin CM, Young B, Liaw PC, Yazdan-Ashoori P, Ortiz A, Webb B, Kilmer G, Carter DE, Cepinskas G. Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro. Crit Care. 2015;19(1):149. https://doi.org/10.1186/s13054-015-0883-z. (PMID: 25882865; PMCID: PMC4409718).

Article  PubMed  PubMed Central  Google Scholar 

Bozza FA, Garteiser P, Oliveira MF, Doblas S, Cranford R, Saunders D, Jones I, Towner RA, Castro-Faria-Neto HC. Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study. J Cereb Blood Flow Metab. 2010;30(2):440–8. https://doi.org/10.1038/jcbfm.2009.215. (Epub 2009 Oct 21. PMID: 19844239; PMCID: PMC2949132).

Article  PubMed  Google Scholar 

Brochu ME, Girard S, Lavoie K, Sébire G. Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: an experimental study. J Neuroinflammation. 2011;20(8):55. https://doi.org/10.1186/1742-2094-8-55. (PMID: 21599903; PMCID: PMC3121616).

Article  CAS  Google Scholar 

Busund R, Koukline V, Utrobin U, Nedashkovsky E. Plasmapheresis in severe sepsis and septic shock: a prospective, randomised, controlled trial. Intensive Care Med. 2002;28(10):1434–9. https://doi.org/10.1007/s00134-002-1410-7. (Epub 2002 Jul 23 PMID: 12373468).

Article  PubMed  Google Scholar 

Cai M, Du B, Si Y, Miao J, Ge J, Zhang J, Song J, Bao H. Knockdown of VDAC1 alleviates the cognitive dysfunction secondary to sepsis-associated encephalopathy. Am J Transl Res. 2021;13(7):7538–55 (PMID: 34377234; PMCID: PMC8340252).

CAS  PubMed  PubMed Central  Google Scholar 

Catalão CHR, Santos-Junior NN, da Costa LHA, Souza AO, Cárnio EC, Sebollela A, Alberici LC, Rocha MJA. Simvastatin Prevents long-term cognitive deficits in sepsis survivor rats by reducing neuroinflammation and neurodegeneration. Neurotox Res. 2020;38(4):871–86. https://doi.org/10.1007/s12640-020-00222-z. (Epub 2020 Jun 10 PMID: 32524380).

Article  CAS  PubMed  Google Scholar 

Catarina AV, Luft C, Greggio S, Venturin GT, Ferreira F, Marques EP, Rodrigues L, Wartchow K, Leite MC, Gonçalves CA, Wyse ATS, Da Costa JC, De Oliveira JR, Branchini G, Nunes FB. Fructose-1,6-bisphosphate preserves glucose metabolism integrity and reduces reactive oxygen species in the brain during experimental sepsis. Brain Res. 2018;1(1698):54–61. https://doi.org/10.1016/j.brainres.2018.06.024. (Epub 2018 Jun 19 PMID: 29932894).

Article  CAS  Google Scholar 

Catarina AV, Branchini G, Bettoni L, De Oliveira JR, Nunes FB. Sepsis-associated encephalopathy: from pathophysiology to progress in experimental studies. Mol Neurobiol. 2021;58(6):2770–9. https://doi.org/10.1007/s12035-021-02303-2. (Epub 2021 Jan 26 PMID: 33495934).

Article  CAS  PubMed  Google Scholar 

Chacqueneau AL, Desrumaux-Becquet A, Debillon T, NGuyen MA, Bessaguet S, Bost-Bru C, Leroy P, Wroblewski I. Encéphalopathie associée au sepsis (EAS), un cas pédiatrique [A child with sepsis-associated encephalopathy]. Arch Pediatr. 2013;20(10):1120–5. https://doi.org/10.1016/j.arcped.2013.06.027. (French; Epub 2013 Aug 13. PMID: 23953625).

Article  PubMed  Google Scholar 

Chaudhry N, Duggal AK. Sepsis associated encephalopathy. Adv Med. 2014;2014:762320. https://doi.org/10.1155/2014/762320.

Article  PubMed  PubMed Central  Google Scholar 

Chen Q, Yu W, Shi J, Shen J, Gao T, Zhang J, Xi F, Li J, Li N. Insulin alleviates the inflammatory response and oxidative stress injury in cerebral tissues in septic rats. J Inflamm (lond). 2014;20(11):18. https://doi.org/10.1186/1476-9255-11-18. (PMID: 25093012; PMCID: PMC4108965).

Article  CAS  Google Scholar 

Chen J, Shi X, Diao M, Jin G, Zhu Y, Hu W, Xi S. A retrospective study of sepsis-associated encephalopathy: epidemiology, clinical features and adverse outcomes. BMC Emerg Med. 2020;20(1):77. https://doi.org/10.1186/s12873-020-00374-3. (PMID: 33023479; PMCID: PMC7539509).

Article  PubMed  PubMed Central  Google Scholar 

Chen H, Dong B, Shi Y, Yu Y, Xie K. Hydrogen alleviates neuronal injury and neuroinflammation induced by microglial activation via the nuclear factor erythroid 2-related factor 2 pathway in sepsis-associated encephalopathy. Neuroscience. 2021;1(466):87–100. https://doi.org/10.1016/j.neuroscience.2021.05.003. (Epub 2021 May 13 PMID: 33992722).

Article  CAS  Google Scholar 

Chung HY, Wickel J, Brunkhorst FM, Geis C. Sepsis-associated encephalopathy: from delirium to dementia? J Clin Med. 2020;9(3):703. https://doi.org/10.3390/jcm9030703. (PMID: 32150970; PMCID: PMC7141293).

Article  PubMed  PubMed Central  Google Scholar 

Comim CM, Cassol OJ Jr, Abreu I, Moraz T, Constantino LS, Vuolo F, Galant LS, de Rochi N, Dos Santos Morais MO, Scaini G, Barichello T, Streck EL, Quevedo J, Dal-Pizzol F. Erythropoietin reverts cognitive impairment and alters the oxidative parameters and energetic metabolism in sepsis animal model. J Neural Transm (vienna). 2012;119(11):1267–74. https://doi.org/10.1007/s00702-012-0774-2. (Epub 2012 Feb 19 PMID: 22350588).

Article  CAS  PubMed  Google Scholar 

Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A. Surviving sepsis campaign: research priorities for sepsis and septic shock. Intensive Care Med. 2018;44(9):1400–26. https://doi.org/10.1007/s00134-018-5175-z.

Article  PubMed  PubMed Central  Google Scholar 

Cotena S, Piazza O. Sepsis-associated encephalopathy. Transl Med UniSa. 2012;18(2):20–7 (PMID: 23905041; PMCID: PMC3728775).

Google Scholar 

Crippa IA, Subirà C, Vincent JL, Fernandez RF, Hernandez SC, Cavicchi FZ, Creteur J, Taccone FS. Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis. Crit Care. 2018;22(1):327. https://doi.org/10.1186/s13054-018-2258-8. (PMID: 30514349; PMCID: PMC6280405).

Article  PubMed  PubMed Central  Google Scholar 

Cruickshank M, Henderson L, MacLennan G, Fraser C, Campbell M, Blackwood B, Gordon A, Brazzelli M. Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review. Health Technol Assess. 2016;20(25):1–118. https://doi.org/10.3310/hta20250. (PMID: 27035758; PMCID: PMC4828957).

Article  PubMed  PubMed Central  Google Scholar 

Czempik PF, Pluta MP, Krzych ŁJ. Sepsis-associated brain dysfunction: a review of current literature. Int J Environ Res Public Health. 2020;17(16):5852. https://doi.org/10.3390/ijerph17165852. (PMID: 32806705; PMCID: PMC7460246).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Czempik PF, Gąsiorek J, Bąk A, Krzych ŁJ. Ultrasonic assessment of optic nerve sheath diameter in patients at risk of sepsis-associated brain dysfunction: a preliminary report. Int J Environ Res Public Health. 2020;17(10):3656. https://doi.org/10.3390/ijerph17103656. (PMID: 32456003; PMCID: PMC7277340).

Article  PubMed  PubMed Central  Google Scholar 

Deng S, Ai Y, Gong