Di Micco, R., Krizhanovsky, V., Baker, D. & d’Adda di Fagagna, F. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat. Rev. Mol. Cell Biol. 22, 75–95 (2021).

Article  PubMed  Google Scholar 

Baker, D. J. et al. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature 530, 184–189 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, L. et al. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 34, 75–89 (2022).

Article  CAS  PubMed  Google Scholar 

Zhu, Y. et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell 15, 428–435 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh, R., Letai, A. & Sarosiek, K. Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nat. Rev. Mol. Cell Biol. 20, 175–193 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Reilly, L. A., Huang, D. C. & Strasser, A. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J. 15, 6979–6990 (1996).

Article  PubMed  PubMed Central  Google Scholar 

Linette, G. P., Li, Y., Roth, K. & Korsmeyer, S. J. Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. Proc. Natl. Acad. Sci. USA 93, 9545–9552 (1996).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brady, H. J., Gil-Gomez, G., Kirberg, J. & Berns, A. J. Bax alpha perturbs T cell development and affects cell cycle entry of T cells. EMBO J. 15, 6991–7001 (1996).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ichim, G. et al. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol. Cell 57, 860–872 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Passos, J. et al. Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP. Preprint at Research Square https://doi.org/10.21203/rs.3.rs-1247316/v1 (2022).