*National Joint Local Engineering Laboratory for Cell Engineering and Biomedicine Technique, Guizhou Province Key Laboratory of Regenerative Medicine, Key Laboratory of Adult Stem Cell Translational Research (Chinese Academy of Medical Sciences)

†Department of Clinical Medical College

‡Neurological Department, Affiliated Hospital of Guizhou Medical University

§Department of Cell Biology, Medical College of Soochow University, Suzhou, China

∥Department of Gastroenterology, Affiliated Hospital of Guizhou Medical University

¶Department of Gastrointestinal Surgery, Affiliated Cancer Hospital of Guizhou Medical University

#Department of Pharmacology, School of Basic Medicine, Guizhou Medical University, Guiyang, China

F.Z. and S.L. were co-first authors and contributed equally to this work.

All authors contributed to the development of this review, wrote, edited, and reviewed the drafts, and approved the final manuscript.

This work was supported by grants from The Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (2019PT310013), Doctor of Guizhou Medical University starts the fund (XBHJ [2020] 018).Science and Technology Plan Project of Baiyun District (BKHT[2019] No. 43). Guiyang Science and Technology Plan Project, ZKHT [2019]-9-14-18. Science and Technology Foundation Project of Guizhou Provincial Health Commission, gzwjkj2019-1-100.

The authors declare no conflicts of interest.

Correspondence: Jianwei Xu, PhD, 9# Beijing Road, Guiyang, China. E-mail: [email protected]; Zejun Wang, 1# Beijing West Road, Guiyang, China. E-mail: [email protected]