Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. 2015. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer. 136, E359‒386.

Article  CAS  PubMed  Google Scholar 

Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394‒424.

Article  PubMed  Google Scholar 

Coulon S., Heindryckx F., Geerts A., Van Steenkiste C., Colle I., Van Vlierberghe H. 2011. Angiogenesis in chronic liver disease and its complications. Liver Int. 31, 146‒162.

Article  CAS  PubMed  Google Scholar 

Chidambaranathan-Reghupaty S., Fisher P.B., Sarkar D. 2021. Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification. Adv. Cancer Res. 149, 1‒61.

Article  PubMed  Google Scholar 

Chen Z., Xie H., Hu M., Huang T., Hu Y., Sang N., Zhao Y. 2020. Recent progress in treatment of hepatocellular carcinoma. Am. J. Cancer Res. 10, 2993‒3036.

CAS  PubMed  PubMed Central  Google Scholar 

Luo W., Zhang Y., He G., Yu M., Zheng M., Liu L., Zhou X. 2017. Effects of radiofrequency ablation versus other ablating techniques on hepatocellular carcinomas: a systematic review and meta-analysis. World J. Surg. Oncol. 15, 126.

Article  PubMed  PubMed Central  Google Scholar 

Chang Y., Jeong S.W., Young Jang J., Jae Kim Y. 2020. Recent updates of transarterial chemoembolilzation in hepatocellular carcinoma. Int. J. Mol. Sci. 21 (21), 8165.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sacco R., Tapete G., Simonetti N., Sellitri R., Natali V., Melissari S., Cabibbo G., Biscaglia L., Bresci G., Giacomelli L. 2017. Transarterial chemoembolization for the treatment of hepatocellular carcinoma: A review. J. Hepatocell. Carcinoma. 4, 105‒110.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lencioni R., De Baere T., Soulen M.C., Rilling W.S., Geschwind J.F. 2016. Lipiodol transarterial chemoembolization for hepatocellular carcinoma: A systematic review of efficacy and safety data. Hepatology. 64, 106‒116.

Article  CAS  PubMed  Google Scholar 

Wang J.H., Zhao L.F., Wang H.F., Wen Y.T., Jiang K.K., Mao X.M., Zhou Z.Y., Yao K.T., Geng Q.S., Guo D., Huang Z.X. 2019. GenCLiP 3: Mining human genes' functions and regulatory networks from PubMed based on co-occurrences and natural language processing. Bioinformatics. btz807.

Barrett T., Troup D.B., Wilhite S.E., Ledoux P., R-udnev D., Evangelista C., Kim I.F., Soboleva A., Tomashevsky M., Marshall K.A., Phillippy K.H., Sherman P.M., Muertter R.N., Edgar R. 2009. NCBI GEO: Archive for high-throughput functional genomic data. Nucleic Acids Res. 37, D885‒D890.

Article  CAS  PubMed  Google Scholar 

Larriba Y., Rueda C., Fernández M.A., Peddada S.D. 2019. Microarray data normalization and robust detection of rhythmic features. Methods Mol. Biol. 1986, 207‒225.

Article  CAS  PubMed  Google Scholar 

Wan Z., Zhao B., Zhang X., Zhao Y. 2020. Drug discovery in cardiovascular disease identified by text mining and data analysis. Ann. Palliat. Med. 9, 3089‒3099.

Article  PubMed  Google Scholar 

Huang Da W., Sherman B.T., Lempicki R.A. 2009. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44‒57.

Article  PubMed  Google Scholar 

Szklarczyk D., Gable A.L., Nastou K.C., Lyon D., Kirsch R., Pyysalo S., Doncheva N.T., Legeay M., Fang T., Bork P., Jensen L.J., Von Mering C. 2021. The STRING database in 2021: Customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res. 49, D605‒D612.

Article  CAS  PubMed  Google Scholar 

Bader G.D., Hogue C.W. 2003. An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinf. 4, 2.

Article  Google Scholar 

Tang Z., Li C., Kang B., Gao G., Li C., Zhang Z. 2017. GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Aci-ds Res. 45, W98–W102.

Article  CAS  Google Scholar 

Huang T., Ye W., Lin X. 2021. Alternative splicing events in immune infiltration of lung adenocarcinoma. Med. Sci. Monit. 27, e934491.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z., Lin E., Zhuang H., Xie L., Feng X., Liu J., Yu Y. 2020. Construction of a novel gene-based model for prognosis prediction of clear cell renal cell carcinoma. Cancer Cell Int. 20, 27.

Article  PubMed  PubMed Central  Google Scholar 

Li T., Fan J., Wang B., Traugh N., Chen Q., Liu J.S., Li B., Liu X.S. 2017. TIMER: A Web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77, e108‒e110.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Griffith M., Griffith O.L., Coffman A.C., Weible J.V., Mcmichael J.F., Spies N.C., Koval J., Das I., Callaway M.B., Eldred J.M., Miller C.A., Subramanian J., Govindan R., Kumar R.D., Bose R., Ding L., Walker J.R., Larson D.E., Dooling D.J., Smith S.M., Ley T.J., Mardis E.R., Wilson R.K. 2013. DGIdb: Mining the druggable genome. Nat. Methods. 10, 1209‒1210.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Freshour S.L., Kiwala S., Cotto K.C., Coffman A.C., Mcmichael J.F., Song J.J., Griffith M., Griffith O.L., Wagner A.H. 2021. Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res. 49, D1144‒D1151.

Article  CAS  PubMed  Google Scholar 

Silva J.P., Berger N.G., Tsai S., Christians K.K., Clarke C.N., Mogal H., White S., Rilling W., Gamblin T.C. 2017. Transarterial chemoembolization in hepatocellular carcinoma with portal vein tumor thrombosis: a systematic review and meta-analysis. HPB (Oxford). 19, 659‒666.

Article  PubMed  Google Scholar 

Ellery P.E., Maroney S.A., Cooley B.C., Luyendyk J.P., Zogg M., Weiler H., Mast A.E. 2015. A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development. Blood. 125, 4078‒4084.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morse M.A., Sun W., Kim R., He A.R., Abada P.B., Mynderse M., Finn R.S. 2019. The role of angiogenesis in hepatocellular carcinoma. Clin. Cancer Res. 25, 912‒920.

Article  CAS  PubMed  Google Scholar 

Kubala M.H., Declerck Y.A. 2019. The plasminogen activator inhibitor-1 paradox in cancer: A mechanistic understanding. Cancer Metastasis Rev. 38, 483‒492.

Article  PubMed  PubMed Central  Google Scholar 

Carmeliet P., Stassen J.M., Schoonjans L., Ream B., Van Den Oord J.J., De Mol M., Mulligan R.C., Collen D. 1993. Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis. J. Clin. Invest. 92, 2756‒2760.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marquard S., Thomann S., Weiler S.M.E., Bissinger M., Lutz T., Sticht C., Toth M., De La Torre C., Gretz N., Straub B.K., Marquardt J., Schirmacher P., Breuhahn K. 2020. Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis. Cell Commun. Signal. 18, 166.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma T., Jayaraman S., Wang K.S., Song Y., Yang B., Li J., Bastidas J.A., Verkman A.S. 2001. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am. J. Physiol. Cell Physiol. 280 (1), C126‒C134.

Article  CAS  PubMed  Google Scholar 

Li L., Zhang H., Ma T., Verkman A.S. 2009. Very high aquaporin-1 facilitated water permeability in mouse gallbladder. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G816‒G822.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nico B., Ribatti D. 2010. Aquaporins in tumor growth and angiogenesis. Cancer Lett. 294, 135‒138.

Article  CAS  PubMed  Google Scholar 

Luo L.M., Xia H., Shi R., Zeng J., Liu X.R., Wei M. 2017. The association between aquaporin-1 expression, microvessel density and the clinicopathological features of hepatocellular carcinoma. Oncol. Lett. 14, 7077‒7084.

PubMed  PubMed Central  Google Scholar 

Anthony T.L., Brooks H.L., Boassa D., Leonov S., Yanochko G.M., Regan J.W., Yool A.J. 2000. Cloned human aquaporin-1 is a cyclic GMP-gated ion channel. Mol. Pharmacol. 57, 576‒588.

Article  CAS  PubMed  Google Scholar 

De Ieso M.L., Pei J.V., Nourmohammadi S., Smith E., Chow P.H., Kourghi M., Hardingham J.E., Yool A.J. 2019. Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration. Sci. Rep. 9, 12635.

Article  PubMed  PubMed Central  Google Scholar 

Jiang Y. 2009. Aquaporin-1 activity of plasma membrane affects HT20 colon cancer cell migration. IUBMB Life. 61, 1001‒1009.

Article  CAS  PubMed  Google Scholar