Chen J, Garcia EV, Folks RD, Cooke CD, Faber TL, Tauxe EL. Onset of left ventricular mechanical contraction as determined by phase analysis of ECG-gated myocardial perfusion SPECT imaging: development of a diagnostic tool for assessment of cardiac mechanical dyssynchrony. J Nucl Cardiol 2005;12:687‐95.

Article  PubMed  Google Scholar 

Trimble MA, Velazquez EJ, Adams GL, Honeycutt EF, Pagnanelli RA, Barnhart HX, et al. Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony. Nucl Med Commun 2008;29:374‐81.

Article  PubMed  PubMed Central  Google Scholar 

He Z, Li D, Cui C, Qin HY, Zhao Z, Hou X, et al. Predictive values of left ventricular mechanical dyssynchrony for CRT response in heart failure patients with different pathophysiology. J Nucl Cardiol 2022;29:2637‐48.

Article  PubMed  Google Scholar 

Mesquita CT, Peix A, de Amorim FF, Giubbini R, Karthikeyan G, Massardo T, et al. Clinical and gated SPECT MPI parameters associated with super-response to cardiac resynchronization therapy. J Nucl Cardiol 2022;29:1166‐74.

Article  PubMed  Google Scholar 

Wang C, Shi J, Ge J, Tang H, He Z, Liu Y, et al. Left ventricular systolic and diastolic dyssynchrony to improve cardiac resynchronization therapy response in heart failure patients with dilated cardiomyopathy. J Nucl Cardiol 2021;28:1023‐36.

Article  PubMed  Google Scholar 

Hu X, Qian Z, Zou F, Xue S, Zhang X, Wang Y, et al. A mild dyssynchronous contraction pattern detected by SPECT myocardial perfusion imaging predicts super-response to cardiac resynchronization therapy. Front Cardiovasc Med 2022;9:906467.

Article  PubMed  PubMed Central  Google Scholar 

Mukherjee A, Patel CD, Naik N, Sharma G, Roy A. Quantitative assessment of cardiac mechanical dyssynchrony and prediction of response to cardiac resynchronization therapy in patients with non-ischaemic dilated cardiomyopathy using equilibrium radionuclide angiography. Europace 2016;18:851‐7.

Article  PubMed  Google Scholar 

Hung GU, Zou J, He Z, Zhang X, Tsai SC, Wang CY, et al. Left-ventricular dyssynchrony in viable myocardium by myocardial perfusion SPECT is predictive of mechanical response to CRT. Ann Nucl Med 2021;35:947‐54.

Article  PubMed  Google Scholar 

Peix A, Karthikeyan G, Massardo T, Kalaivani M, Patel C, Pabon LM, et al. Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT). J Nucl Cardiol 2021;28:55‐64.

Article  PubMed  Google Scholar 

Wang J, Wang Y, Yang M, Shao S, Tian Y, Shao X, et al. Mechanical contraction to guide CRT left-ventricular lead placement instead of electrical activation in myocardial infarction with left ventricular dysfunction: an experimental study based on non-invasive gated myocardial perfusion imaging and invasive electroanatomic mapping. J Nucl Cardiol 2020;27:419‐30.

Article  PubMed  Google Scholar 

Chen J, Nagaraj H, Bhambhani P, Kliner DE, Soman P, Garcia EV, et al. Effect of alcohol septal ablation in patients with hypertrophic cardiomyopathy on left-ventricular mechanical dyssynchrony as assessed by phase analysis of gated SPECT myocardial perfusion imaging. Int J Cardiovasc Imaging 2012;28:1375‐84.

Article  PubMed  Google Scholar 

AlJaroudi W, Aggarwal H, Venkataraman R, Heo J, Iskandrian AE, Hage FG. Impact of left ventricular dyssynchrony by phase analysis on cardiovascular outcomes in patients with end-stage renal disease. J Nucl Cardiol 2010;17:1058‐64.

Article  PubMed  Google Scholar 

Aggarwal H, AlJaroudi WA, Mehta S, Mannon R, Heo J, Iskandrian AE, et al. The prognostic value of left ventricular mechanical dyssynchrony using gated myocardial perfusion imaging in patients with end-stage renal disease. J Nucl Cardiol 2014;21:739‐46.

Article  PubMed  Google Scholar 

Aljaroudi WA, Hage FG, Hermann D, Doppalapudi H, Venkataraman R, Heo J, et al. Relation of left-ventricular dyssynchrony by phase analysis of gated SPECT images and cardiovascular events in patients with implantable cardiac defibrillators. J Nucl Cardiol 2010;17:398‐404.

Article  PubMed  Google Scholar 

Cho SG, Jabin Z, Park KS, Kim J, Kang SR, Kwon SY, et al. Clinical values of left ventricular mechanical dyssynchrony assessment by gated myocardial perfusion SPECT in patients with acute myocardial infarction and multivessel disease. Eur J Nucl Med Mol Imaging 2017;44:259‐66.

Article  PubMed  Google Scholar 

Uebleis C, Hellweger S, Laubender RP, Becker A, Sohn HY, Lehner S, et al. Left ventricular dyssynchrony assessed by gated SPECT phase analysis is an independent predictor of death in patients with advanced coronary artery disease and reduced left ventricular function not undergoing cardiac resynchronization therapy. Eur J Nucl Med Mol Imaging 2012;39:1561‐9.

Article  PubMed  Google Scholar 

Fujito H, Yoda S, Hatta T, Miyagawa M, Tanaka Y, Fukumoto K, et al. Prognostic value of the normalization of left ventricular mechanical dyssynchrony after revascularization in patients with coronary artery disease. Heart Vessels 2022;37:1395‐410.

Article  PubMed  Google Scholar 

Hatta T, Yoda S, Hayase M, Monno K, Hori Y, Fujito H, et al. Prognostic value of left ventricular dyssynchrony assessed with nuclear cardiology in patients with known or suspected stable coronary artery disease with preserved left ventricular ejection fraction. Int Heart J 2020;61:685‐94.

Article  CAS  PubMed  Google Scholar 

Fujito H, Yoda S, Hatta T, Hori Y, Hayase M, Miyagawa M, et al. Prognostic significance of left ventricular dyssynchrony assessed with nuclear cardiology for the prediction of major cardiac events after revascularization. Intern Med 2021;60:3679‐92.

Article  PubMed  PubMed Central  Google Scholar 

Miyagawa M, Yoda S, Fujito H, Hatta T, Tanaka Y, Fukumoto K, et al. Prognostic risk stratification based on left ventricular mechanical dyssynchrony in patients at low or intermediate risk of major cardiac events using the J-ACCESS risk model. Heart Vessels 2023;38:195‐206.

Article  PubMed  Google Scholar 

Lu X, Zhao M, Tian C, Wei H, Gao M, Yang X, et al. Prognostic value of ventricular mechanical dyssynchrony in patients with left ventricular aneurysm: a comparative study of medical and surgical treatment. J Nucl Cardiol 2022;29:652‐60.

Article  PubMed  Google Scholar 

AlJaroudi W, Alraies MC, Hachamovitch R, Jaber WA, Brunken R, Cerqueira MD, et al. Association of left ventricular mechanical dyssynchrony with survival benefit from revascularization: a study of gated positron emission tomography in patients with ischemic LV dysfunction and narrow QRS. Eur J Nucl Med Mol Imaging 2012;39:1581‐91.

Article  PubMed  Google Scholar 

Hage FG, Aggarwal H, Patel K, Chen J, Jacobson AF, Heo J, et al. The relationship of left ventricular mechanical dyssynchrony and cardiac sympathetic denervation to potential sudden cardiac death events in systolic heart failure. J Nucl Cardiol 2014;21:78‐85.

Article  PubMed  Google Scholar 

Tian Y, Zhao M, Li W, Zhu Z, Mi H, Li X, et al. Left ventricular mechanical dyssynchrony analzyed by Tc-99m sestamibi SPECT and F-18 FDG PET in patients with ischemic cardiomyopathy and the prognostic value. Int J Cardiovasc Imaging 2020;36:2063‐71.

Article  PubMed  Google Scholar 

AlJaroudi W, Alraies MC, Menon V, Brunken RC, Cerqueira MD, Jaber WA. Predictors and incremental prognostic value of left ventricular mechanical dyssynchrony response during stress-gated positron emission tomography in patients with ischemic cardiomyopathy. J Nucl Cardiol 2012;19:958‐69.

Article  PubMed  Google Scholar 

Goldberg AS, Alraies MC, Cerqueira MD, Jaber WA, Aljaroudi WA. Prognostic value of left ventricular mechanical dyssynchrony by phase analysis in patients with non-ischemic cardiomyopathy with ejection fraction 35–50% and QRS < 150 ms. J Nucl Cardiol 2014;21:57‐66.

Article  PubMed  Google Scholar 

Kano N, Okumura T, Isobe S, Sawamura A, Watanabe N, Fukaya K, et al. Left ventricular phase entropy: novel prognostic predictor in patients with dilated cardiomyopathy and narrow QRS. J Nucl Cardiol 2018;25:1677‐87.

Article  PubMed  Google Scholar 

Wang C, Tang H, Zhu F, Jiang Z, Shi J, Zhou Y, et al. Prognostic value of left-ventricular systolic and diastolic dyssynchrony measured from gated SPECT MPI in patients with dilated cardiomyopathy. J Nucl Cardiol 2020;27:1582‐91.

Article  PubMed  Google Scholar 

Chen CC, Shen TY, Chang MC, Hung GU, Chen WC, Kao CH, et al. Stress-induced myocardial ischemia is associated with early post-stress left ventricular mechanical dyssynchrony as assessed by phase analysis of 201Tl gated SPECT myocardial perfusion imaging. Eur J Nucl Med Mol Imaging 2012;39:1904‐9.

Article  PubMed  PubMed Central  Google Scholar 

Hida S, Chikamori T, Tanaka H, Igarashi Y, Shiba C, Usui Y, et al. Diagnostic value of left ventricular dyssynchrony after exercise and at rest in the detection of multivessel coronary artery disease on single-photon emission computed tomography. Circ J 2012;76:1942‐52.

Article  PubMed  Google Scholar 

Cortés CM, Aramayo GE, Barboza PE, Crottogini A, Embon MA. Impact of early post-stress (99m)Tc sestamibi ECG-gated SPECT myocardial perfusion imaging on the detection of ischemic LV dyssynchrony: an early step in the stunning cascade. Int J Cardiovasc Imaging 2021;37:1789‐98.

Article  PubMed  Google Scholar 

Zhang F, Yang W, Wang Y, Tang H, Wang J, Shao X, et al. Is there an association between hibernating myocardium and left ventricular mechanical dyssynchrony in patients with myocardial infarction? Hell J Nucl Med 2018;21:28‐34.

PubMed  Google Scholar 

Murrow J, Esteves F, Galt J, Chen J, Garcia E, Lin J, et al. Characterization of mechanical dyssynchrony measured by gated single photon emission computed tomography phase analysis after acute ST-elevation myocardial infarction. J Nucl Cardiol 2011;18:912‐9.

Article  PubMed  PubMed Central  Google Scholar 

Naya M, Murthy VL, Taqueti VR, Foster CR, Klein J, Garber M, et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med 2014;55:248‐55.

Article  PubMed  Google Scholar 

Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, et al. Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and (99m)Tc-tetrofosmin: method and validation. J Nucl Cardiol 2017;24:268‐77.

Article  PubMed  Google Scholar 

Sciammarella M, Shrestha UM, Seo Y, Gullberg GT, Botvinick EH. A combined static-dynamic single-dose imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT. J Nucl Cardiol 2019;26:763‐71.

Article  PubMed