Mahanimbine Suppresses the Proliferation of Lung Cancer A549 Cells Via Inducing Intrinsic Apoptotic Pathway

Ahmad A, Ansari IA (2021) Carvacrol exhibits chemopreventive potential against cervical cancer cells via caspase-dependent apoptosis and abrogation of cell cycle progression. Anticancer Agents Med Chem 21:2224–2235. https://doi.org/10.2174/1871520621999201230201258

Article  CAS  PubMed  Google Scholar 

Ahmad A, Tiwari RK, Saeed M, Ahmad I, Ansari IA (2022) Glycyrrhizin mediates downregulation of notch pathway resulting in initiation of apoptosis and disruption in the cell cycle progression in cervical cancer cells. Nutr Cancer 74:622–639. https://doi.org/10.1080/01635581.2021.1895234

Article  CAS  PubMed  Google Scholar 

Amna U, Halimatussakdiah H, Wahyuningsih P, Saidi N, Nasution R, Astryna S (2019) Phytochemical screening and in vitro cytotoxic activity of hexane extract of temurui (Murraya koenigii (Linn.) Spreng) leaves against human cervical cancer (HeLa) cell line. IOP Conf Ser: Mater Sci Eng 523:012018.

Article  CAS  Google Scholar 

Ansari IA, Ahmad A, Imran MA, Saeed M, Ahmad I (2021) Organosulphur compounds induce apoptosis and cell cycle arrest in cervical cancer cells via downregulation of HPV E6 and E7 oncogenes. Anticancer Agents Med Chem 21:393–405. https://doi.org/10.2174/1871520620999200818154456

Article  CAS  PubMed  Google Scholar 

Bhandari PR (2012) Curry leaf (Murraya koenigii) or cure leaf: review of its curative properties. J Med Nutr Nutraceut 1:92–97. https://doi.org/10.4103/2278-019X.101295

Article  CAS  Google Scholar 

Birari R, Javia V, Bhutani KK (2010) Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats. Fitoterapia 81:1129–1133. https://doi.org/10.1016/j.fitote.2010.07.013

Article  CAS  PubMed  Google Scholar 

Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH (2013) Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol 14:32. https://doi.org/10.1186/1471-2121-14-32

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cancer Treatment Centers of America (2021) Lung cancer types. Last updated: May 21, 2021. Available at https://www.cancercenter.com/cancer-types/lung-cancer/types, accessed on May 28, 2021.

Chakrabarty M, Nath A, Khasnobis S, Chakrabarty M, Konda Y, Harigaya Y, Komiyama K (1997) Carbazole alkaloids from Murraya koenigii. Phytochemistry 46:751–755. https://doi.org/10.1016/s0031-9422(97)00345-2

Article  CAS  PubMed  Google Scholar 

Dahiya J, Singh J, Kumar A, Sharma A (2016) Isolation, characterization and quantification of an anxiolytic constituent - mahanimbine, from Murraya koenigii Linn. Spreng Leaves J Ethnopharmacol 193:706–711. https://doi.org/10.1016/j.jep.2016.10.014

Article  CAS  PubMed  Google Scholar 

Ismail A, Noolu B, Gogulothu R, Perugu S, Rajanna A, Babu SK (2016) Cytotoxicity and proteasome inhibition by alkaloid extract from Murraya koenigii leaves in breast cancer cells-molecular docking studies. J Med Food 19:1155–1165. https://doi.org/10.1089/jmf.2016.3767

Article  CAS  PubMed  Google Scholar 

Ju J, Gothai S, Hasanpourghadi M, Nasser AA, Ibrahim IAA, Shahzad N, Pandurangan AK, Muniandy K, Kumar SS, Arulselvan P (2018) Anticancer potential of Moringa oleifera flower extract in human prostate cancer PC-3 cells via induction of apoptosis and downregulation of AKT pathway. Phcog Mag 14:477–481. https://doi.org/10.4103/pm.pm_516_17

Article  CAS  Google Scholar 

Kaushik N, Lee SJ, Choi TG, Baik KY, Uhm HS, Kim CH, Kaushik NK, Choi EH (2015) Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells. Sci Rep 5:8726. https://doi.org/10.1038/srep08726

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, Nuñez G, Peter ME, Tschopp J, Yuan J, Piacentini M, Zhivotovsky B, Melino G (2009) Nomenclature Committee on Cell Death 2009. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 16:3–11. https://doi.org/10.1038/cdd.2008.150

Article  CAS  PubMed  Google Scholar 

Li L, Huizhi L, Binu W, Xinxin D, Longjun W, Liping Y, Yingying Z (2018) Anticancer activity of mukonal against human laryngeal cancer cells involves apoptosis, cell cycle arrest, and inhibition of PI3K/AKT and MEK/ERK signalling pathways. Med Sci Monit 24:7295–7302. https://doi.org/10.12659/MSM.910702

Article  PubMed  PubMed Central  Google Scholar 

Liou GY, Storz P (2010) Reactive oxygen species in cancer. Free Radic Res 44:479–496. https://doi.org/10.3109/10715761003667554

Article  CAS  PubMed  Google Scholar 

Mani V, MohdAzahan NS, Ramasamy K, Lim SM, Abdul Majeed AB (2021) Mahanimbine improved aging-related memory deficits in mice through enhanced cholinergic transmission and suppressed oxidative stress, amyloid levels, and neuroinflammation. Brain Sci 12:12. https://doi.org/10.3390/brainsci12010012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin-Cordero C, Leon-Gonzalez AJ, Calderon-Montano JM, Burgos-Moron E, Lopez-Lazaro M (2012) Pro-oxidant natural products as anticancer agents. Curr Drug Targets 13:1006–1028. https://doi.org/10.2174/138945012802009044

Article  CAS  PubMed  Google Scholar 

Nadaf S, Desai R, More T, Shinde P, Dakare S, Killedar S (2020) Antiproliferative and caspase-mediated apoptosis inducing effects of Murraya koenigii seeds against cancer cells. S Afr J Bot 132:328–337. https://doi.org/10.1016/j.sajb.2020.05.021

Article  CAS  Google Scholar 

NavaneethaKrishnan S, Rosales JL, Lee KY (2019) ROS-mediated cancer cell killing through cietary phytochemicals. Oxid Med Cell Longev 2019:9051542. https://doi.org/10.1155/2019/9051542

Article  CAS  PubMed  PubMed Central  Google Scholar 

Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981–2002. J Nat Prod 66:1022–1037. https://doi.org/10.1021/np030096l

Article  CAS  PubMed  Google Scholar 

Noolu B, Gogulothu R, Bhat M, Qadri SS, Reddy VS, Reddy GB, Ismail A (2016) In vivo inhibition of proteasome activity and tumour growth by Murraya koenigii leaf extract in breast cancer xenografts and by its active flavonoids in breast cancer cells. Anticancer Agents Med Chem 16:1605–1614. https://doi.org/10.2174/1871520616666160520112210

Article  CAS  PubMed  Google Scholar 

Pei C, He Q, Liang S, Gong X (2018) Mahanimbine exerts anticancer effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of AKT/mammalian target of rapamycin (mTOR) and signal transducer and activator of transcription 3 (STAT3) signalling pathways. Med Sci Monit 24:6975–6983. https://doi.org/10.12659/MSM.911013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Porter AG, Jänicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6:99–104. https://doi.org/10.1038/sj.cdd.4400476

Article  CAS  PubMed  Google Scholar 

Qie S, Diehl JA (2016) Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med 94:1313–1326. https://doi.org/10.1007/s00109-016-1475-3

Article  CAS  PubMed  Google Scholar 

Ross MF, Kelso GF, Blaikie FH, James AM, Cochemé HM, Filipovska A, Da Ros T, Hurd TR, Smith RA, Murphy MP (2005) Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology. Biochemistry 70:222–230. https://doi.org/10.1007/s10541-005-0104-5

Article  CAS  PubMed  Google Scholar 

Singh UP, Bhat HR (2017) Discovery of 1,3,5-triazine based novel EGFR-tyrosine kinase inhibitor against human lung carcinoma. Ann Oncol 28:II10. https://doi.org/10.1093/annonc/mdx089.005

Article  Google Scholar 

Tantapakul C, Phakhodee W, Laphookhieo S, Ritthiwigrom T, Cheenpracha S (2014) Cytotoxic carbazole alkaloids from the stems of Murraya koenigii. Chem Nat Compd 50:186–188. https://doi.org/10.1007/s10600-014-0909-9

Article  CAS  Google Scholar 

Wang Y, Yu H, Zhang J, Gao J, Ge X, Lou G (2015) Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer 15:682. https://doi.org/10.1186/s12885-015-1706-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei M, Liu B, Gu Q, Su L, Yu Y, Zhu Z (2013) Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1). Cell Oncol 36:79–93. https://doi.org/10.1007/s13402-012-0115-3

Article  CAS  Google Scholar 

WHO (2021) World Health Organization factsheet on Cancer. https://www.who.int/news-room/fact-sheets/detail/cancer. Accessed 3 Feb 2022

Xie H, Zhang T, Yang N, Li Z, Liu Y (2020) Anticancer effects of mahanimbine alkaloid on the human bladder cancer cells are due to the induction of G0/G1 cell cycle arrest, apoptosis and autophagy. J BUON 25:1166–1171

PubMed  Google Scholar 

Yeh CT, Huang WC, Rao YK, Ye M, Lee WH, Wang LS, Tzeng DT, Wu CH, Shieh YS, Huang CY, Chen YJ, Hsiao M, Wu AT, Yang Z, Tzeng YM (2013) A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells. Carcinogenesis 34:2918–2928. https://doi.org/10.1093/carcin/bgt255

Article  CAS  PubMed  Google Scholar 

Żuryń A, Litwiniec A, Safiejko-Mroczka B, Klimaszewska-Wiśniewska A, Gagat M, Krajewski A, Gackowska L, Grzanka D (2016) The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line. Int J Oncol 48:2521–2533. https://doi.org/10.3892/ijo.2016.3444

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif