Nutritional and inflammatory peripheral blood markers for risk assessment of chronic subdural hematoma: a case-control study

Chronic subdural hematoma (CSDH) is a commonly encountered neurosurgical condition, especially among elderly patients [1]. The incidence of this disease, ranging from 8.2 to 20.6 per 100,000 people annually, will continue to increase due to the global aging tendency [2], [3].

As so far, the risk factors of CSDH remains unclear. Previous researches demonstrated that inflammation might contribute to the formation of CSDH [4]. Moreover, some investigations also found that the nutritional factors were correlated with CSDH. Several nutrition-related peripheral blood biomarkers such as high-density lipoprotein, prealbumin, and blood urea nitrogen have been identified to be associated with the mortality and re-formation of CSDH [5], [6], [7]. Sceratti et al. also found the nutritional status was likely to influence the clinical outcome of CSDH patients [8]. Therefore, we hypothesized that a hyper-inflammatory state and a poor nutritional status were associated with the appearance of CSDH. In this study, we performed a case-control study to identify whether the nutritional and inflammatory peripheral blood markers were correlated with CSDH.

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