COVID-19 disease is associated with higher morbidity and mortality in cancer patients. Our study aimed to characterize the optimal strategy to improve vaccine induced protection against COVID-19 in children and adolescents with cancer. Results from The SerOzNET study will contribute comprehensive data on serology, cellular immune correlates from functional T-cell assays, quality of life data, and associated toxicity in relation to COVID-19 vaccination in children and adults with cancer. In this plan, we describe the statistics that will be used to report results of the SerOzNET study. SerOzNET examines COVID-19 vaccine response in children and adolescents with cancer.

The authors have declared no competing interest.

Funding support was received from Cancer Australia, Victorian Cancer Agency, The Leukaemia Foundation (Australia), and Monash Health.

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

Monash Health Human Research and Ethics Committee gave ethical approval for this work. Study Title: SARS-CoV-2 post-vaccine surveillance studies in Australian children and adults with cancer [SerOzNET] HREC Reference Number: HREC/76506/MonH-2021-268415(v2) Monash Health Local Reference: RES-21-0000-337A ERM Project ID: 76506 research@monashhealth.org www.monashhealth.org/page/research

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Yes

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Yes

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Yes

All data produced in the present study are available upon reasonable request to the authors.