This randomized crossover study of 210 individuals with pancreatic and nonpancreatic lesions compared wet-suction versus stylet slow-pull techniques for endoscopic ultrasound-guided fine-needle biopsy with a Franseen or fork-tip needle. Tissue cores, defined as intact tissue of ≥ 550 μm in length, were obtained more frequently with the wet-suction technique (71.4 % vs. 61.4 %; P = 0.03). Diagnostic accuracy was similarly high, regardless of sampling technique.
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