Advances in Pharmacology and Pharmacy Vol. 11(2), pp. 168 - 178
DOI: 10.13189/app.2023.110208
Reprint (PDF) (558Kb)

Sandip Badadhe 1,*, Gurdeeep Singh 1,2, Neetesh Jain 3
1 Oriental College of Pharmacy & Research, Oriental University, Indore, Madhya Pradesh, India
2 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
3 University Institute of Pharmacy, Oriental University, Indore, Madhya Pradesh, India

ABSTRACT

The Gamma Oryzanol (GOZ), the concept of biopharmaceutical classification systems (BCS), methods for enhancement of solubility and bioavailability, gamma oryzanol have been used for a number of applications, especially due to strong antioxidant activity and lipid-lowering properties. As gamma oryzanol has many therapeutic effects, it can be beneficial for the pharmaceutical industry. But the use of gamma oryzanol in clinical and functional meals systems may be restrained due to low water solubility, poor bioavailability and fast metabolism of gamma oryzanol. -Oryzanol is insoluble in water. Numerous methods of solubilizing complex for cosmetic, pharmaceutical, food uses have been defined. Based totally on initial showing of changed dropped SNEDDS formula, eight components of GOZ stacked SNEEDS have been organized utilizing Capryol 90, Labrasol and Transcutol HP as oil, surfactant as well as cosurfactant, separately. Some of the extraordinary surfactants screened, Labrasol confirmed exceptional solubilizing capability for GOZ (94.69±1.04 mg/mL). On one hundred fold dilution, the percentage transmittance of GOZ SNEDDS formula was observed to be among 97.87% ± 0.30% and 99.57% ± 0.06%. From droplet size analysis, it was seen that GOZ loaded SNEDDS formulation had the mean particle size in the range of 15.03±0.18 to 22.97±0.44 nm indicating their efficiency as SNEDDS. Visual perception showed that there was no stage partition or any flocculation in all formulations and the actual appearance of all plans in underlying one hour of in vitro discharge research, just 12.23% ± 0.45% as well as 42.33% ± 2.78% of GOZ was dissolved after pure drug as well as advertised tablets correspondingly.

KEYWORDS
Gamma Oryzanol, Solubility, Bioavailability, SNEDDS

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Sandip Badadhe , Gurdeeep Singh , Neetesh Jain , "Preparation, Characterization and In-vitro Evaluation of Gamma Oryzanol Loaded Self-nanoemulsifying Drug Delivery Systems," Advances in Pharmacology and Pharmacy, Vol. 11, No. 2, pp. 168 - 178, 2023. DOI: 10.13189/app.2023.110208.

(b). APA Format:
Sandip Badadhe , Gurdeeep Singh , Neetesh Jain (2023). Preparation, Characterization and In-vitro Evaluation of Gamma Oryzanol Loaded Self-nanoemulsifying Drug Delivery Systems. Advances in Pharmacology and Pharmacy, 11(2), 168 - 178. DOI: 10.13189/app.2023.110208.