Genes and my development [Essays]

Mitchell A. Lazar Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA Corresponding author: lazarpennmedicine.upenn.edu

When I started my independent research lab in 1989, I did not know Terri Grodzicker and I did not realize that she was just beginning what would become her decades-long leadership of Genes & Development. G&D had been founded just 2 years before (Inglis 2007), and as my lab developed I watched G&D rapidly join the ranks of the most respected, most influential, and most selective molecular biology journals. People weren't talking so much about “impact” at that time, but it was clear to me that G&D papers had it. In the words of former Supreme Court Justice Potter Stewart, “I know it when I see it.” Of course, he was talking about something else. But I digress.

Under Terri's stewardship, G&D papers have consistently been well-written and addressed important questions related to the regulation of gene expression or development. Sometimes they told a “story,” but more often they provided an interesting, robust, and convincing piece of a scientific puzzle. The term “cool finding” comes to mind. This was the kind of science that I hoped my lab would come to be recognized for, and I really wanted to publish our best work in G&D. After a few years of running my own lab studying nuclear receptor (NR) mechanisms, we generated a set of findings that I thought were exciting and G&D-worthy.

I submitted the paper (literally, since email wasn't yet standard) and waited. I didn't have to wait long because one great thing about G&D was (and is) their short turnaround time. Unfortunately, though, the reviews were negative, although the rejection letter from Terri assured me that “we are interested in this area of research, and would certainly consider future manuscripts.” The reviews were mixed, and I considered protesting the decision. However, I realized that most authors …

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