Dale, H. H. The action of certain esters and ethers of choline, and their relation to muscarine. J. Pharmacol. Exp. Ther. 6, 147–190 (1914).
Ewins, A. J. Acetylcholine, a new active principle of ergot. Biochem. J. 8, 44 (1914).
Article CAS PubMed PubMed Central Google Scholar
Katz, B. & Miledi, R. The measurement of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction. Proc. R. Soc. Lond. B 161, 483–495 (1965).
Article CAS PubMed Google Scholar
Peper, K., Bradley, R. J. & Dreyer, F. The acetylcholine receptor at the neuromuscular junction. Physiol. Rev. 62, 1271–1340 (1982).
Article CAS PubMed Google Scholar
Picciotto, M. R., Higley, M. J. & Mineur, Y. S. Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron 76, 116–129 (2012).
Article CAS PubMed PubMed Central Google Scholar
Ballinger, E. C., Ananth, M., Talmage, D. A. & Role, L. W. Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline. Neuron 91, 1199–1218 (2016).
Article CAS PubMed PubMed Central Google Scholar
Lohani, S. et al. Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity. Nat. Neurosci. 25, 1706–1713 (2022). This study uses in vivo wide-field imaging of cortical activity and ACh release to show distinct activity profiles associated with specific behavioural states.
Article CAS PubMed Google Scholar
Záborszky, L. et al. Specific basal forebrain-cortical cholinergic circuits coordinate cognitive operations. J. Neurosci. 38, 9446–9458 (2018).
Article PubMed PubMed Central Google Scholar
Stifani, N. Motor neurons and the generation of spinal motor neuron diversity. Front. Cell Neurosci. 8, 293 (2014).
Article PubMed PubMed Central Google Scholar
Alkaslasi, M. R. et al. Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord. Nat. Commun. 12, 2471 (2021).
Article CAS PubMed PubMed Central Google Scholar
Higley, M. J. et al. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS ONE 6, e19155 (2011).
Article CAS PubMed PubMed Central Google Scholar
Kljakic, O., Janickova, H., Prado, V. F. & Prado, M. A. M. Cholinergic/glutamatergic co-transmission in striatal cholinergic interneurons: new mechanisms regulating striatal computation. J. Neurochem. 142 (Suppl. 2), 90–102 (2017).
Article CAS PubMed Google Scholar
Mayer, C. et al. Developmental diversification of cortical inhibitory interneurons. Nature 555, 457–462 (2018).
Article CAS PubMed PubMed Central Google Scholar
Obermayer, J. et al. Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention. Nat. Commun. 10, 5280 (2019).
Article CAS PubMed PubMed Central Google Scholar
Mineur, Y. S. et al. Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs. Mol. Psychiatry 27, 1829–1838 (2022).
Article CAS PubMed PubMed Central Google Scholar
Granger, A. J. et al. Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner. eLife 9, e57749 (2020).
Article CAS PubMed PubMed Central Google Scholar
Dudai, A., Yayon, N., Soreq, H. & London, M. Cortical VIP+/ChAT+ interneurons: from genetics to function. J. Neurochem. 158, 1320–1333 (2021).
Article CAS PubMed Google Scholar
Mesulam, M. M., Mufson, E. J., Levey, A. I. & Wainer, B. H. Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J. Comp. Neurol. 214, 170–197 (1983).
Article CAS PubMed Google Scholar
Woolf, N. J. Cholinergic systems in mammalian brain and spinal cord. Prog. Neurobiol. 37, 475–524 (1991).
Article CAS PubMed Google Scholar
Eckenstein, F. & Baughman, R. W. Two types of cholinergic innervation in cortex, one co-localized with vasoactive intestinal polypeptide. Nature 309, 153–155 (1984).
Article CAS PubMed Google Scholar
Geula, C. et al. Basal forebrain cholinergic system in the dementias: vulnerability, resilience, and resistance. J. Neurochem. 158, 1394–1411 (2021).
Article CAS PubMed PubMed Central Google Scholar
Bertrand, D. & Wallace, T. L. A review of the cholinergic system and therapeutic approaches to treat brain disorders. Curr. Top. Behav. Neurosci. 45, 1–28 (2020).
Article CAS PubMed Google Scholar
Ferreira-Vieira, T. H., Guimaraes, I. M., Silva, F. R. & Ribeiro, F. M. Alzheimer’s disease: targeting the cholinergic system. Curr. Neuropharmacol. 14, 101–115 (2016).
Article CAS PubMed PubMed Central Google Scholar
Solari, N. & Hangya, B. Cholinergic modulation of spatial learning, memory and navigation. Eur. J. Neurosci. 48, 2199–2230 (2018).
Article PubMed PubMed Central Google Scholar
Knox, D. The role of basal forebrain cholinergic neurons in fear and extinction memory. Neurobiol. Learn. Mem. 133, 39–52 (2016).
Article CAS PubMed PubMed Central Google Scholar
Kumar Yadav, R. & Mallick, B. N. Dopaminergic- and cholinergic-inputs from substantia nigra and pedunculo-pontine tegmentum, respectively, converge in amygdala to modulate rapid eye movement sleep in rats. Neuropharmacology 193, 108607 (2021).
Article CAS PubMed Google Scholar
Vanini, G. & Torterolo, P. Sleep-wake neurobiology. Adv. Exp. Med. Biol. 1297, 65–82 (2021).
Article CAS PubMed Google Scholar
Jones, B. E. Arousal and sleep circuits. Neuropsychopharmacology 45, 6–20 (2020).
Article CAS PubMed Google Scholar
Shao, X. & Feldman, J. Central cholinergic regulation of respiration: nicotinic receptors. Acta Pharmacol. Sin. 30, 761–770 (2009).
Article CAS PubMed PubMed Central Google Scholar
Dani, J. A. & Bertrand, D. Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 47, 699–729 (2007).
Article CAS PubMed Google Scholar
Thiele, A. Muscarinic signaling in the brain. Annu. Rev. Neurosci. 36, 271–294 (2013).
Article CAS PubMed Google Scholar
Nathanson, N. M. Regulation of muscarinic acetylcholine receptor expression and function. Prog. Brain Res. 109, 165–168 (1996).
Article CAS PubMed Google Scholar
Gaimarri, A. et al. Regulation of neuronal nicotinic receptor traffic and expression. Brain Res. Rev. 55, 134–143 (2007).
Article CAS PubMed Google Scholar
Wess, J. Molecular basis of muscarinic acetylcholine receptor function. Trends Pharmacol. Sci. 14, 308–313 (1993).
Article CAS PubMed Google Scholar
Zoli, M., Pucci, S., Vilella, A. & Gotti, C. Neuronal and extraneuronal nicotinic acetylcholine receptors. Curr. Neuropharmacol. 16, 338–349 (2018).
Article CAS PubMed PubMed Central Google Scholar
Zaborszky, L., van den Pol, A. & Gyengesi, E. in The Mouse Nervous System (eds Watson, C., Paxinos, G. & Puelles, L.) 684–718 (Academic, 2012).
Huerta-Ocampo, I., Dautan, D., Gut, N. K., Khan, B. & Mena-Segovia, J. Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons. Sci. Rep. 11, 9055 (2021).
留言 (0)