Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, Gulyaeva AA, et al. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5(4):536–44.

Article  Google Scholar 

WHO Coronavirus (COVID-19) Dashboard. 2022. https://covid19.who.int. accessed Jan 14 2022.

Meinhardt J, Radke J, Dittmayer C, Franz J, Thomas C, Mothes R, et al. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci. 2021;24(2):168–75.

Article  CAS  Google Scholar 

Mehta OP, Bhandari P, Raut A, Kacimi SEO, Huy NT. Coronavirus disease (COVID-19): comprehensive review of clinical presentation. Front Public Health. 2021;8:582932.

Article  Google Scholar 

Polidori MC, Sies H, Ferrucci L, Benzing T. COVID-19 mortality as a fingerprint of biological age. Ageing Res Rev. 2021;67:101308.

Article  CAS  Google Scholar 

Matschke J, Lütgehetmann M, Hagel C, Sperhake JP, Schröder AS, Edler C, et al. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol. 2020;19(11):919–29.

Article  CAS  Google Scholar 

Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. Lancet Neurol. 2020;19(9):767–83.

Article  CAS  Google Scholar 

Thakur KT, Miller EH, Glendinning MD, Al-Dalahmah O, Banu MA, Boehme AK, et al. COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital. Brain. 2021;144(9):2696–708.

Article  Google Scholar 

Casagrande M, Fitzek A, Püschel K, Aleshcheva G, Schultheiss HP, Berneking L, et al. Detection of SARS-CoV-2 in human retinal biopsies of deceased COVID-19 patients. Ocul Immunol Inflamm. 2020;28(5):721–5.

Article  CAS  Google Scholar 

Araujo-Silva CA, Marcos AAA, Marinho PM, Branco AMC, Roque A, Romano AC, et al. Presumed SARS-CoV-2 viral particles in the human retina of patients with COVID-19. JAMA Ophthalmol. 2021;139(9):1015–21.

Article  Google Scholar 

Nasiri N, Sharifi H, Bazrafshan A, Noori A, Karamouzian M, Sharifi A. Ocular manifestations of COVID-19: a systematic review and meta-analysis. J Ophthal Vis Res. 2021;16(1):103–12.

Google Scholar 

Jevnikar K, Jaki Mekjavic P, Vidovic Valentincic N, Petro G, Globocnik PM. An update on COVID-19 related ophthalmic manifestations. Ocul Immunol Inflamm. 2021;29(4):684–9.

Article  CAS  Google Scholar 

de Figueiredo CS, Raony Í, Giestal-de-Araujo E. SARS-CoV-2 targeting the retina: host-virus interaction and possible mechanisms of viral tropism. Ocul Immunol Inflamm. 2020;28(8):1301–4.

Article  Google Scholar 

Qing H, Li Z, Yang Z, Shi M, Huang Z, Song J, et al. The possibility of COVID-19 transmission from eye to nose. Acta Ophthalmol. 2020;98(3):e388.

Article  CAS  Google Scholar 

Invernizzi A, Torre A, Parrulli S, Zicarelli F, Schiuma M, Colombo V, et al. Retinal findings in patients with COVID-19: results from the SERPICO-19 study. EClinicalMedicine. 2020;27:100550.

Article  Google Scholar 

Ferreira FL, Bota DP, Bross A, Mélot C, Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001;286(14):1754–8.

Article  CAS  Google Scholar 

Liu F, Li L, Xu M, Wu J, Luo D, Zhu Y, et al. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. J Clin Virol. 2020;127:104370.

Article  CAS  Google Scholar 

Vélez M, Velásquez Salazar P, Acosta-Reyes J, Vera-Giraldo CY, Santiago Franco J, Jiménez C, et al. Clinical factors for the prognosis of severe illness and death in patients with COVID-19. Ed. School of Medicine, University of Antioquia. 2020; https://doi.org/10.13140/RG.2.2.28812.05767

Sethi CS, Lewis GP, Fisher SK, Leitner WP, Mann DL, Luthert PJ, et al. Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2005;46(1):329–42.

Article  Google Scholar 

Shahidehpour RK, Higdon RE, Crawford NG, Neltner JH, Ighodaro ET, Patel E, et al. Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain. Neurobiol Aging. 2021;99:19–27.

Article  CAS  Google Scholar 

Bachstetter AD, Van Eldik LJ, Schmitt FA, Neltner JH, Ighodaro ET, Webster SJ, et al. Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. Acta Neuropathol Commun. 2015;3:32.

Article  Google Scholar 

Said EA, Al-Reesi I, Al-Shizawi N, Jaju S, Al-Balushi MS, Koh CY, et al. Defining IL-6 levels in healthy individuals: a meta-analysis. J Med Virol. 2021;93(6):3915–24.

Article  CAS  Google Scholar 

Huang I, Pranata R. Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis. J Intensive Care. 2020;8:36–44.

Article  Google Scholar 

Ali N. Elevated level of C-reactive protein may be an early marker to predict risk for severity of COVID-19. J Med Virol. 2020;92(11):2409–11.

Article  CAS  Google Scholar 

Henry BM, Aggarwal G, Wong J, Benoit S, Vikse J, Plebani M, et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: a pooled analysis. Am J Emerg Med. 2020;38(9):1722–6.

Article  Google Scholar 

Teo KY, Invernizzi A, Staurenghi G, Cheung CMG. COVID-19 related retinal micro-vasculopathy - a review of current evidence: COVID-19 related retinal micro-vasculopathy. Am J Ophthalmol. 2022;235:98–110.

Article  CAS  Google Scholar 

Jidigam VK, Singh R, Batoki JC, Milliner C, Sawant OB, Bonilha VL, et al. Histopathological assessments reveal retinal vascular changes, inflammation, and gliosis in patients with lethal COVID-19. Graefes Arch Clin Exp Ophthalmol. 2022;260(4):1275–88.

Article  CAS  Google Scholar 

Zapata MÁ, Banderas García S, Sánchez-Moltalvá A, Falcó A, Otero-Romero S, Arcos G, et al. Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity. Br J Ophthalmol. 2022;106(4):559–63.

Article  Google Scholar 

Nag TC. Pathogenic mechanisms contributing to the vulnerability of aging human photoreceptor cells. Eye (Lond). 2021;35(11):2917–29.

Article  Google Scholar 

Nag TC, Kathpalia P, Gorla S, Wadhwa S. Localization of nitro-tyrosine immunoreactivity in human retina. Ann Anat. 2019;223:8–18.

Article  Google Scholar 

Cuenca N, Fernández-Sánchez L, Campello L, Maneu V, De la Villa P, Lax P, et al. Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases. Prog Retin Eye Res. 2014;43:17–75.

Article  CAS  Google Scholar 

Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, et al. Müller cells in the healthy and diseased retina. Prog Retin Eye Res. 2006;25(4):397–424.

Article  CAS  Google Scholar 

Cuenca N, Ortuño-Lizarán I, Sánchez-Sáez X, Kutsyr O, Albertos-Arranz H, Fernández-Sánchez L, et al. Interpretation of OCT and OCTA images from a histological approach: clinical and experimental implications. Prog Retin Eye Res. 2020;77:100828.

Article  CAS  Google Scholar 

Baumal CR, Sarraf D, Bryant T, Gui W, Muakkassa N, Pichi F, et al. Henle fiber layer hemorrhage: clinical features and pathogenesis. Br J Ophthalmol. 2021;105(3):374–80.

Article  Google Scholar 

Mustafi D, Do BK, Rodger DC, Rao NA. Relationship of epiretinal membrane formation and macular edema development in a large cohort of uveitic eyes. Ocul Immunol Inflamm. 2021;29(5):915–21.

Article  Google Scholar 

Chen W, Shen X, Zhang P, Xu G, Jiang R, Huang X, et al. Clinical characteristics, long-term surgical outcomes, and prognostic factors of epiretinal membrane in young patients. Retina. 2019;39(8):1478–87.

Article  CAS  Google Scholar 

Ramírez JM, Ramírez AI, Salazar JJ, de Hoz R, Triviño A. Changes of astrocytes in retinal ageing and age-related macular degeneration. Exp Eye Res. 2001;73(5):601–15.

Article  Google Scholar 

Kaur C, Foulds WS, Ling EA. Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management. Prog Retin Eye Res. 2008;27(6):622–47.

Article  CAS  Google Scholar 

Simões e Silva AC, Silveira KD, Ferreira AJ, Teixeira MM. ACE2, angiotensin-(1–7) and Mas receptor axis in inflammation and fibrosis. Br J Pharmacol. 2013;169(3):477–92.

Article  Google Scholar 

Zhou L, Xu Z, Guerra J, Rosenberg AZ, Fenaroli P, Eberhart CG, et al. Expression of the SARS-CoV-2 receptor ACE2 in human retina and diabetes-implications for retinopathy. Invest Ophthalmol Vis Sci. 2021;62(7):6.

Article  CAS  Google Scholar 

Robles JP, Zamora M, Adan-Castro E, Siqueiros-Marquez L, Martinez de la Escalera G, Clapp C. The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling. J Biol Chem. 2022;298(3):101695.

Article  CAS  Google Scholar 

Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, et al. SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE2. Circ Res. 2021;128(9):1323–6.

Article  CAS  Google Scholar 

Wang Y, Detrick B, Yu ZX, Zhang J, Chesky L, Hooks JJ. The role of apoptosis within the retina of coronavirus-infected mice. Invest Ophthalmol Vis Sci. 2000;41(10):3011–8.

CAS  Google Scholar 

Zinkernagel MS, Chinnery HR, Ong ML, Petitjean C, Voigt V, McLenachan S, et al. Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection. Am J Pathol. 2013;182(3):875–85.

Article  CAS  Google Scholar 

Streit WJ, Sammons NW, Kuhns AJ, Sparks DL. Dystrophic microglia in the aging human brain. Glia. 2004;45(2):208–12.

Article  Google Scholar 

Singaravelu J, Zhao L, Fariss RN, Nork TM, Wong WT. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain Struct Funct. 2017;222(6):2759–71.

Article  Google Scholar 

Kutsyr O, Noailles A, Martínez-Gil N, Maestre-Carballa L, Martinez-Garcia M, Maneu V, et al. Short-term high-fat feeding exacerbates degeneration