Carta et al,19Carta A.F. Lichtblau M. Berlier C. et al.The impact of breathing hypoxic gas and oxygen on pulmonary hemodynamics in patients with pulmonary hypertension. 2022b

Patients assessed with RHC.

149FiO21.0 for 10 minmPAP 36 ± 12 mm Hg
PVR 5.0 ± 2.8 WUSpO2 92 ± 3%
PaO2 9.4 ± 1.8 kPamPAP −4.4 ± 11 mm Hg (−12%)
PVR -0.4 ± 3.1 WU (- 8%)—Shigetoshi et al,27Shigetoshi M. Hatanaka K. Ogawa A. et al.Oxygen inhalation can selectively dilate pulmonary arteries in patients with chronic thromboembolic pulmonary hypertension before balloon angioplasty. 2022b

Patients assessed with RHC.

52 CTEPH5L/min for 10 minmPAP 40.4 ± 8.8 mm Hg
PVR 8.5 ± 3.7WU
CI 2.51 ± 1.5 1.1 L/min/m2—mPAP −3.8 ± 8.1 mm Hg (−9%)
PVR -0.7 ± 3.2 WU (−8%)
CI -0.14 ± 1.1 L/min/m2 (−6%)—Boutou et al,28Boutou A.K. Dipla K. Zafeiridis A. et al.A randomized placebo-control trial of the acute effects of oxygen supplementation on exercise hemodynamics, autonomic modulation, and brain oxygenation in patients with pulmonary hypertension. 20219 (3 CTEPH, 6 PAH)FiO20.4 during exercise—SpO2 92 ± 3%—Constant load exercise endurance air 10.3 ± 3.9 min, oxygen 14.9 ± 4.0 minGroth et al,22Groth A. Saxer S. Bader P.R. et al.Acute hemodynamic changes by breathing hypoxic and hyperoxic gas mixtures in pulmonary arterial and chronic thromboembolic pulmonary hypertension. 2018a

Data are presented as median and interquartile.

,b

Patients assessed with RHC.

28FiO21.0 for 10 minmPAP 35 (31; 44) mm Hg
PVR 4.8 (3.1; 7.0)WUSpO2 97 (83;95) %
PaO2 9.5 (6.8;9.3) kPamPAP −4 (−6 to −2) mm Hg (−11%)
PVR -0.4 (−1 to 0) WU (−8%)—Ulrich et al,30Ulrich S. Schneider S.R. Bloch K.E. Effect of hypoxia and hyperoxia on exercise performance in healthy individuals and in patients with pulmonary hypertension: a systematic review. 2017N = 22FiO20.5 for 8–12 minmPAP 35 ± 9 mm Hg
PVR 4.7 ± 2.5 mm HgSpO2 95 ± 3%
PaO2 8.8 ± 2.5 kPaNot reportedIncremental exercise test +19.7 (10.5;28.9) W (+17%)
Constant load exercise endurance +671 (392; 951) sec (+117%)Leuchte et al,21Leuchte H.H. Baezner C.J. Baumgartner R.A. et al.Acute hemodynamic responses to supplemental oxygen and their prognostic implications in pulmonary hypertension. 2013b

Patients assessed with RHC.

104FiO20.4 for >10 minmPAP 46.4 ± 1.3 mm Hg
PVR 10.1 ± 0.5WUSaO2 87.5 ± 0.8%
PaO2 63.9 ± 1.6 mm HgmPAP −4.1 ± 1.3 mm Hg (−9%)
PVR -0.5 ± 0.5WU (−5%)—Roberts et al,25Roberts D.H. Lepore J.J. Maroo A. et al.Oxygen therapy improves cardiac index and pulmonary vascular resistance in patients with pulmonary hypertension. 2001b

Patients assessed with RHC.

N = 23
13 PAH
4 PortoPul
2 COPD
2 CHD (1ASD & 1VSD)
1 syst.skler
1 HIVFiO21.0 via facemask for 5 minmPAP 56 ± 3 mm Hg
RAP 8 ± 1 mm Hg
PAWP 8 ± 1 mm Hg
PVR 14.6 ± 1.4WU
CI 2.1 ± 0.1 L/min/m2SaO2 91 ± 1%
PaO2 8.53 ± 0.4 kPamPAP −3 ± 2 mm Hg (−5%)
RAP no change
PAWP no change
PVR -4 ± 1.0WU (−27%)
CI + 0.4 ± 0.2 L/min/m2 (+19%)SaO2 99 ± 1%
PaO2 41 ± 3.7 kPa
PVR/systemic vascular resistance, 0.53 ± 0.04 to 0.48 ± 0.03
The beneficial effect on PVR was independent of the etiology of pulmonary hypertensionPitton et al,26Pitton M.B. Hatanaka K. Ogawa A. et al.[Effect of oxygen inhalation on hemodynamics in chronic thromboembolic pulmonary hypertension]. 1998b

Patients assessed with RHC.

31 CTEPH10 L/min for 20 mingroup mild PH:
mPAP 25.9 ± 6 mm Hg
Severe PH: mPAP 53.4 ± 17.1 mm Hg—Group mild PH:
mPAP −11.1 ± 16.7 mm Hg (−11%)
Severe PH: mPAP −4.6 ± 4 mm Hg (−5%)—Morgan et al,23Morgan J.M. Griffiths M. du Bois R.M. et al.Hypoxic pulmonary vasoconstriction in systemic sclerosis and primary pulmonary hypertension. 1991b

Patients assessed with RHC.

7 SSc
8 PAHFiO2 0.6 for 30 minSSc mPAP 43 ± 15 mm Hg
PVR 10 ± 4 WU
PAH mPAP 54 ± 20 mm Hg
PVR 12 ± 5WUSSc
PaO2 9.6 ± 3.4 kPa
PAH
PaO2 9.9 ± 3.4 kPaSSc mPAP −4.8 mm Hg (−11%)
PVR -2.4WU (−24%)
PAH mPAP = −5%, PVR = −12% (data from figures)—Packer et al,24Packer M. Lee W.H. Medina N. et al.Systemic vasoconstrictor effects of oxygen administration in obliterative pulmonary vascular disorders. 1985b

Patients assessed with RHC.

N = 14
8 idiopat.
4 Lupus e.
1 CTEPH
1 CHD (corrected by surgery)FiO2 0.5–0.7 20–30 min
Ambient air for 20–30 minmPAP 62 ± 5 mm Hg
RAP 12 ± 2 mm Hg
CI 1.9 ± 0.2 L/min/m2PaO2 = 8.67 ± 0.53 kPamPAP −5 ± 5 mm Hg (−8%)
RAP -2 ± 1 mm Hg (−16%)
CI -0.1 ± 1.2 L/min/m2 (−5%)
PAWP = no changesHR = −4%
Systemic arterial pressure = +4%
PaO2 = 19.73 ± 3.11