Andersen KAA, Carhart‐Harris R, Nutt DJ, Erritzoe D. Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies. Acta Psychiatr Scand. 2021;143:101–18.
Davis AK, Barrett FS, May DG, Cosimano MP, Sepeda ND, Johnson MW, et al. Effects of Psilocybin-assisted therapy on major depressive disorder: A randomized clinical trial. JAMA Psychiatry. 2021;78:481.
De Gregorio D, Aguilar-Valles A, Preller KH, Heifets BD, Hibicke M, Mitchell J, et al. Hallucinogens in mental health: Preclinical and clinical studies on LSD, Psilocybin, MDMA, and Ketamine. J Neurosci. 2021;41:891–900.
Article PubMed PubMed Central Google Scholar
dos Santos RG, Osório FL, Crippa JAS, Riba J, Zuardi AW, Hallak JEC. Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): A systematic review of clinical trials published in the last 25 years. Ther Adv Psychopharmacol. 2016;6:193–213.
Article PubMed PubMed Central Google Scholar
Grob CS, Danforth AL, Chopra GS, Hagerty M, McKay CR, Halberstadt AL, et al. Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer. Arch Gen Psychiatry. 2011;68:71.
Article CAS PubMed Google Scholar
Carhart-Harris RL, Bolstridge M, Day CMJ, Rucker J, Watts R, Erritzoe DE, et al. Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Psychopharmacology 2018;235:399–408.
Article CAS PubMed Google Scholar
Daws RE, Timmermann C, Giribaldi B, Sexton JD, Wall MB, Erritzoe D, et al. Increased global integration in the brain after psilocybin therapy for depression. Nat Med. 2022;28:844–51.
Article CAS PubMed Google Scholar
Griffiths RR, Johnson MW, Carducci MA, Umbricht A, Richards WA, Richards BD, et al. Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. J Psychopharmacol. 2016;30:1181–97.
Article CAS PubMed PubMed Central Google Scholar
Johnson M, Richards W, Griffiths R. Human hallucinogen research: Guidelines for safety. J Psychopharmacol. 2008;22:603–20.
Article CAS PubMed PubMed Central Google Scholar
Phelps J. Developing guidelines and competencies for the training of Psychedelic therapists. J Humanist Psychol. 2017;57:450–87.
Reiff CM, Richman EE, Nemeroff CB, Carpenter LL, Widge AS, Rodriguez CI, et al. Psychedelics and Psychedelic-assisted psychotherapy. AJP 2020;177:391–410.
Kwan AC, Olson DE, Preller KH, Roth BL. The neural basis of psychedelic action. Nat Neurosci. 2022;25:1407–19.
Article CAS PubMed Google Scholar
Carhart-Harris R, Nutt D. Serotonin and brain function: A tale of two receptors. J Psychopharmacol. 2017;31:1091–120.
Article CAS PubMed PubMed Central Google Scholar
Carhart-Harris RL, Friston KJ. REBUS and the anarchic brain: Toward a unified model of the brain action of psychedelics. Pharm Rev. 2019;71:316–44.
Article CAS PubMed PubMed Central Google Scholar
Dajani DR, Uddin LQ. Demystifying cognitive flexibility: Implications for clinical and developmental neuroscience. Trends Neurosci. 2015;38:571–8.
Article CAS PubMed PubMed Central Google Scholar
Millan MJ, Agid Y, Brüne M, Bullmore ET, Carter CS, Clayton NS, et al. Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Disco. 2012;11:141–68.
Snyder HR. Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: A meta-analysis and review. Psychol Bull. 2013;139:81–132.
Southwick SM, Vythilingam M, Charney DS. The psychobiology of depression and resilience to stress: Implications for prevention and treatment. Annu Rev Clin Psychol. 2005;1:255–91.
Stange JP, Alloy LB, Fresco DM. Inflexibility as a vulnerability to depression: A systematic qualitative review. Clin Psychol Sci Pr. 2017;24:245–76.
Doss MK, Považan M, Rosenberg MD, Sepeda ND, Davis AK, Finan PH, et al. Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder. Transl Psychiatry. 2021;11:574.
Article CAS PubMed PubMed Central Google Scholar
Bale TL, Abel T, Akil H, Carlezon WA, Moghaddam B, Nestler EJ, et al. The critical importance of basic animal research for neuropsychiatric disorders. Neuropsychopharmacol. 2019;44:1349–53.
Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson SM. Harnessing psilocybin: Antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice. Proc Natl Acad Sci USA. 2021;118:e2022489118.
Article CAS PubMed PubMed Central Google Scholar
Shao L-X, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, et al. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron 2021;109:2535–44.e4.
Article CAS PubMed PubMed Central Google Scholar
Amodeo DA, Hassan O, Klein L, Halberstadt AL, Powell SB. Acute serotonin 2A receptor activation impairs behavioral flexibility in mice. Behav Brain Res. 2020;395:112861.
Article CAS PubMed Google Scholar
Odland AU, Kristensen JL, Andreasen JT. The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice. Behav Pharmacol. 2021;32:448–52.
Article CAS PubMed Google Scholar
Darmani NA, Martin BR, Pandey U, Glennon RA. Do functional relationships exist between 5-HT1A and 5-HT2 receptors? Pharmacol Biochem Behav. 1990;36:901–6.
Article CAS PubMed Google Scholar
Boulougouris V, Glennon JC, Robbins TW. Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats. Neuropsychopharmacol. 2008;33:2007–19.
Winstanley CA, Theobald DEH, Dalley JW, Glennon JC, Robbins TW. 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: Interactions with global 5-HT depletion. Psychopharmacology 2004;176:376–85.
Article CAS PubMed Google Scholar
Darrah JM, Stefani MR, Moghaddam B. Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm. Behav Pharmacol. 2008;19:225–34.
Article CAS PubMed PubMed Central Google Scholar
Del Arco A, Park J, Wood J, Kim Y, Moghaddam B. Adaptive encoding of outcome prediction by prefrontal cortex ensembles supports behavioral flexibility. J Neurosci. 2017;37:8363–73.
Article PubMed PubMed Central Google Scholar
Park J, Wood J, Bondi C, Del Arco A, Moghaddam B. Anxiety Evokes Hypofrontality and disrupts rule-relevant encoding by dorsomedial prefrontal cortex neurons. J Neurosci. 2016;36:3322–35.
Article CAS PubMed PubMed Central Google Scholar
Kim Y-B, Matthews M, Moghaddam B. Putative γ-aminobutyric acid neurons in the ventral tegmental area have a similar pattern of plasticity as dopamine neurons during appetitive and aversive learning: Associative learning in VTA. Eur J Neurosci. 2010;32:1564–72.
Article PubMed PubMed Central Google Scholar
Bissonette GB, Roesch MR. Neurophysiology of rule switching in the corticostriatal circuit. Neuroscience 2017;345:64–76.
Article CAS PubMed Google Scholar
Izquierdo A, Brigman JL, Radke AK, Rudebeck PH, Holmes A. The neural basis of reversal learning: An updated perspective. Neuroscience 2017;345:12–26.
Article CAS PubMed Google Scholar
Baker PM, Thompson JL, Sweeney JA, Ragozzino ME. Differential effects of 5-HT2A and 5-HT2C receptor blockade on strategy-switching. Behav Brain Res. 2011;219:123–31.
Article CAS PubMed PubMed Central Google Scholar
Murphy-Beiner A, Soar K. Ayahuasca’s ‘afterglow’: Improved mindfulness and cognitive flexibility in ayahuasca drinkers. Psychopharmacology 2020;237:1161–9.
Article CAS PubMed Google Scholar
Hamilton DA, Brigman JL. Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions: Flexibility and frontocortical function. Genes, Brain Behav. 2015;14:4–21.
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