Pommier Y (2006) Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer 6(10):789–802. https://doi.org/10.1038/nrc1977

Article  CAS  PubMed  Google Scholar 

Wang-Gillam A, Li C-P, Bodoky G, Dean A, Shan Y-S, Jameson G, Macarulla T, Lee K-H, Cunningham D, Blanc JF, Hubner RA, Chiu C-F, Schwartsmann G, Siveke JT, Braiteh F, Moyo V, Belanger B, Dhindsa N, Bayever E, Von Hoff DD, Chen L-T, Adoo C, Anderson T, Asselah J, Azambuja A, Bampton C, Barrios CH, Bekaii-Saab T, Bohuslav M, Chang D, Chen J-S, Chen Y-C, Choi HJ, Chung IJ, Chung V, Csoszi T, Cubillo A, DeMarco L, de Wit M, Dragovich T, Edenfield W, Fein LE, Franke F, Fuchs M, Gonzales-Cruz V, Gozza A, Fernando RH, Iaffaioli R, Jakesova J, Kahan Z, Karimi M, Kim JS, Korbenfeld E, Lang I, Lee F-C, Lee K-D, Lipton L, Ma WW, Mangel L, Mena R, Palmer D, Pant S, Park JO, Piacentini P, Pelzer U, Plazas JG, Prasad C, Rau K-M, Raoul J-L, Richards D, Ross P, Schlittler L, Smakal M, Stahalova V, Sternberg C, Seufferlein T, Tebbutt N, Vinholes JJ, Wadlow R, Wenczl M, Wong M (2016) Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet 387(10018):545–557. https://doi.org/10.1016/s0140-6736(15)00986-1

Article  CAS  PubMed  Google Scholar 

Lee HM, Clark EP, Kuijer MB, Cushman M, Pommier Y, Philpot BD (2018) Characterization and structure–activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome. Mol Autism 9:45. https://doi.org/10.1186/s13229-018-0228-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balana-Fouce R, Prada CF, Requena JM, Cushman M, Pommier Y, Alvarez-Velilla R, Escudero-Martinez JM, Calvo-Alvarez E, Perez-Pertejo Y, Reguera RM (2012) Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother 56(10):5264–5270. https://doi.org/10.1128/AAC.00499-12

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burton JH, Mazcko C, LeBlanc A, Covey JM, Ji J, Kinders RJ, Parchment RE, Khanna C, Paoloni M, Lana S, Weishaar K, London C, Kisseberth W, Krick E, Vail D, Childress M, Bryan JN, Barber L, Ehrhart EJ, Kent M, Fan T, Kow K, Northup N, Wilson-Robles H, Tomaszewski J, Holleran JL, Muzzio M, Eiseman J, Beumer JH, Doroshow JH, Pommier Y (2018) NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma. Clin Cancer Res 24(23):5830–5840. https://doi.org/10.1158/1078-0432.CCR-18-1498

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muzzio M, Hu SC, Holleran JL, Parise RA, Eiseman JL, Yellow-Duke AE, Covey JM, Glaze ER, Engelke K, Egorin MJ, McCormick DL, Beumer JH (2015) Plasma pharmacokinetics of the indenoisoquinoline topoisomerase I inhibitor, NSC 743400, in rats and dogs. Cancer Chemother Pharmacol 75(5):1015–1023. https://doi.org/10.1007/s00280-015-2722-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kummar S, Chen A, Gutierrez M, Pfister TD, Wang L, Redon C, Bonner WM, Yutzy W, Zhang Y, Kinders RJ, Ji J, Allen D, Covey JM, Eiseman JL, Holleran JL, Beumer JH, Rubinstein L, Collins J, Tomaszewski J, Parchment R, Pommier Y, Doroshow JH (2016) Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors. Cancer Chemother Pharmacol 78(1):73–81. https://doi.org/10.1007/s00280-016-2998-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holleran JL, Parise RA, Yellow-Duke AE, Egorin MJ, Eiseman JL, Covey JM, Beumer JH (2010) Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776. J Pharm Biomed Anal 52(5):714–720. https://doi.org/10.1016/j.jpba.2010.02.020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cinelli MA, Reddy PV, Lv PC, Liang JH, Chen L, Agama K, Pommier Y, van Breemen RB, Cushman M (2012) Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem 55(24):10844–10862. https://doi.org/10.1021/jm300519w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mosteller RD (1987) Simplified calculation of body-surface area. N Engl J Med 317(17):1098. https://doi.org/10.1056/NEJM198710223171717

Article  CAS  PubMed  Google Scholar 

Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16(1):31–41

Article  CAS  PubMed  Google Scholar 

Ribbing J, Jonsson EN (2004) Power, selection bias and predictive performance of the population pharmacokinetic covariate model. J Pharmacokinet Pharmacodyn 31(2):109–134. https://doi.org/10.1023/b:jopa.0000034404.86036.72

Article  CAS  PubMed  Google Scholar