Aamodt AH, Stovner L, Midthjell K, Hagen K, Zwart JA (2007) Headache prevalence related to diabetes mellitus. The Head-HUNT study. Eur J Neurol 14(7):738–744

Article  CAS  PubMed  Google Scholar 

Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE et al (2012) An integrated map of genetic variation from 1,092 human genomes. Nature 491(7422):56–65. https://doi.org/10.1038/nature11632

Article  CAS  PubMed  Google Scholar 

Abramowitz Y, Roth A, Keren G, Isakov O, Shomron N, Laitman Y et al (2016) Whole-exome sequencing in individuals with multiple cardiovascular risk factors and normal coronary arteries. Coronary Artery Dis 27(4):257–266

Article  Google Scholar 

Adewuyi EO, Sapkota Y, International Endogene Consortium, I., andMe Research, T., International Headache Genetics Consortium, I., Auta A et al (2020) Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity. Genes (basel). https://doi.org/10.3390/genes11030268

Article  PubMed  Google Scholar 

Adewuyi EO, Mehta D, Sapkota Y, Sapkota Y, Yoshihara K, Nyegaard M et al (2021) Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality. Hum Genet 140(3):529–552. https://doi.org/10.1007/s00439-020-02223-6

Article  CAS  PubMed  Google Scholar 

Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L et al (2018) Analysis of shared heritability in common disorders of the brain. Science. https://doi.org/10.1126/science.aap8757

Article  PubMed  Google Scholar 

Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO et al (2015) A global reference for human genetic variation. Nature 526(7571):68–74. https://doi.org/10.1038/nature15393

Article  CAS  PubMed  Google Scholar 

Berisa T, Pickrell JK (2016) Approximately independent linkage disequilibrium blocks in human populations. Bioinformatics 32(2):283

Article  CAS  PubMed  Google Scholar 

Bindesbøll C, Aas A, Ogmundsdottir MH, Pankiv S, Reine T, Zoncu R, Simonsen A (2020) NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease. Sci Rep 10(1):4528. https://doi.org/10.1038/s41598-020-61352-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Biscetti L, De Vanna G, Cresta E, Corbelli I, Gaetani L, Cupini L et al (2021) Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms. J Neuroinflamm 18(1):259. https://doi.org/10.1186/s12974-021-02229-5

Article  Google Scholar 

Boesgaard TW, Gjesing AP, Grarup N, Rutanen J, Jansson PA, Hribal ML et al (2009) Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients–EUGENE2 study. PLoS ONE 4(9):e7236. https://doi.org/10.1371/journal.pone.0007236

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borkum JM (2016) Migraine triggers and oxidative stress: a narrative review and synthesis. Headache 56(1):12–35. https://doi.org/10.1111/head.12725

Article  PubMed  Google Scholar 

Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44(2):512–525. https://doi.org/10.1093/ije/dyv080

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40(4):304–314. https://doi.org/10.1002/gepi.21965

Article  PubMed  PubMed Central  Google Scholar 

Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Patterson N et al (2015) LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genetics 47(3):291–295

Article  CAS  PubMed  Google Scholar 

Bulik-Sullivan B, Finucane HK, Anttila V, Gusev A, Day FR, Loh P-R et al (2015) An atlas of genetic correlations across human diseases and traits. Nat Genetics 47(11):1236–1241. https://doi.org/10.1038/ng.3406

Article  CAS  PubMed  Google Scholar 

Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37(7):658–665. https://doi.org/10.1002/gepi.21758

Article  PubMed  PubMed Central  Google Scholar 

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K et al (2018) The UK Biobank resource with deep phenotyping and genomic data. Nature 562(7726):203–209

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cavestro C, Rosatello A, Micca G, Ravotto M, Marino MP, Asteggiano G, Beghi E (2007) Insulin metabolism is altered in migraineurs: a new pathogenic mechanism for migraine? Headache 47(10):1436–1442. https://doi.org/10.1111/j.1526-4610.2007.00719.x

Article  PubMed  Google Scholar 

Chanda P, Huang H, Arking DE, Bader JS (2013) Fast association tests for genes with FAST. PLoS ONE 8(7):e68585. https://doi.org/10.1371/journal.pone.0068585

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ (2015) Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. https://doi.org/10.1186/s13742-13015-10047-13748

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J et al (2021) The trans-ancestral genomic architecture of glycemic traits. Nat Genet 53(6):840–860

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Yao T, Cai J, Zhang Q, Li S, Li H et al (2022) A novel genetic variant potentially altering the expression of MANBA in the cerebellum associated with attention deficit hyperactivity disorder in Han Chinese children. World J Biol Psychiatry. https://doi.org/10.1080/15622975.2021.2014248

Article  PubMed  Google Scholar 

Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X et al (2011) Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet 44(1):67–72. https://doi.org/10.1038/ng.1019

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chung J, Marini S, Pera J, Norrving B, Jimenez-Conde J, Roquer J et al (2019) Genome-wide association study of cerebral small vessel disease reveals established and novel loci. Brain 142(10):3176–3189. https://doi.org/10.1093/brain/awz233

Article  PubMed  PubMed Central  Google Scholar 

Consortium, IH (2010) Integrating common and rare genetic variation in diverse human populations. Nature 467(7311):52

Article  Google Scholar 

Corpas R, Hernández-Pinto AM, Porquet D, Hernández-Sánchez C, Bosch F, Ortega-Aznar A et al (2017) Proinsulin protects against age-related cognitive loss through anti-inflammatory convergent pathways. Neuropharmacology 123:221–232. https://doi.org/10.1016/j.neuropharm.2017.06.014

Article  CAS  PubMed  Google Scholar 

Daghals I, Sargurupremraj M, Danning R, Gormley P, Malik R, Amouyel P et al (2022) Migraine, stroke, and cervical arterial dissection: shared genetics for a triad of brain disorders with vascular involvement. Neurol Genet 8(1):e653. https://doi.org/10.1212/nxg.0000000000000653

Article  PubMed  PubMed Central  Google Scholar 

Del Moro L, Rota E, Pirovano E, Rainero I (2022) Migraine, brain glucose metabolism and the “neuroenergetic” hypothesis: a scoping review. J Pain. https://doi.org/10.1016/j.jpain.2022.02.006

Article  PubMed  Google Scholar 

Duarte AI, Moreira PI, Oliveira CR (2012) Insulin in central nervous system: more than just a peripheral hormone. J Aging Res 2012:384017. https://doi.org/10.1155/2012/384017

Article  PubMed  PubMed Central  Google Scholar 

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU et al (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genetics 42(2):105–116. https://doi.org/10.1038/ng.520

Article  CAS  PubMed  Google Scholar 

Fagherazzi G, El Fatouhi D, Fournier A, Gusto G, Mancini FR, Balkau B et al (2019) Associations between migraine and type 2 diabetes in women: findings from the E3N cohort study. JAMA Neurol 76(3):257–263. https://doi.org/10.1001/jamaneurol.2018.3960

Article  PubMed  Google Scholar 

Gerring ZF, McRae AF, Montgomery GW, Nyholt DR (2018) Genome-wide DNA methylation profiling in whole blood reveals epigenetic signatures associated with migraine. BMC Genomics 19(1):69. https://doi.org/10.1186/s12864-018-4450-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH et al (2016) Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genetics 48(8):856–866. https://doi.org/10.1038/ng.3598

Article  CAS  PubMed  Google Scholar 

Gray P, Burtness H (1935) Hypoglycemic headache. Endocrinology 19(5):549–560

Article  Google Scholar 

Gross EC, Lisicki M, Fischer D, Sándor PS, Schoenen J (2019) The metabolic face of migraine—from pathophysiology to treatment. Nat Rev Neurol 15(11):627–643

Article  CAS  PubMed  Google Scholar