Tumor-associated macrophage-derived GDNF promotes gastric cancer liver metastasis via a GFRA1-modulated autophagy flux

A. Cervantes, D. Roda, N. Tarazona, S. Rosello, J.A. Perez-Fidalgo, Current questions for the treatment of advanced gastric cancer. Cancer Treat Rev 39, 60–67 (2013)

Article  CAS  PubMed  Google Scholar 

M. Garancini, F. Uggeri, L. Degrate, L. Nespoli, L. Gianotti, A. Nespoli, F. Uggeri, F. Romano, Surgical treatment of liver metastases of gastric cancer: is local treatment in a systemic disease worthwhile? HPB (Oxford) 14, 209–215 (2012)

Article  PubMed  Google Scholar 

C. Allemani, T. Matsuda, V. Di Carlo, R. Harewood, M. Matz, M. Nikšić, A. Bonaventure, M. Valkov, C.J. Johnson, J. Estève, O.J. Ogunbiyi, G. Azevedo e Silva, W.-Q. Chen, S. Eser, G. Engholm, C.A. Stiller, A. Monnereau, R.R. Woods, O. Visser, G.H. Lim, J. Aitken, H.K. Weir, M.P. Coleman, S. Bouzbid, M. Hamdi-Chérif, Z. Zaidi, K. Meguenni, D. Regagba, S. Bayo, T. Cheick Bougadari, S.S. Manraj, K. Bendahhou, A. Fabowale, D. Bradshaw, N.I.M. Somdyala, I. Kumcher, F. Moreno, G.H. Calabrano, S.B. Espinola, B. Carballo Quintero, R. Fita, M.C. Diumenjo, W.D. Laspada, S.G. Ibañez, C.A. Lima, P.C.F. De Souza, K. Del Pino, C. Laporte, M.P. Curado, J.C. de Oliveira, C.L.A. Veneziano, D.B. Veneziano, M.R.D.O. Latorre, L.F. Tanaka, M.S. Rebelo, M.O. Santos, J.C. Galaz, M. Aparicio Aravena, J. Sanhueza Monsalve, D.A. Herrmann, S. Vargas, V.M. Herrera, C.J. Uribe, L.E. Bravo, L.S. Garcia, N.E. Arias-Ortiz, D. Morantes, D.M. Jurado, M.C. Yépez Chamorro, S. Delgado, M. Ramirez, Y.H. Galán Alvarez, P. Torres, F. Martínez-Reyes, L. Jaramillo, R. Quinto, J. Castillo, M. Mendoza, P. Cueva, J.G. Yépez, B. Bhakkan, J. Deloumeaux, C. Joachim, J. Macni, R. Carrillo, J. Shalkow Klincovstein, R. Rivera Gomez, E. Poquioma, G. Tortolero-Luna, D. Zavala, R. Alonso, E. Barrios, A. Eckstrand, C. Nikiforuk, G. Noonan, D. Turner, E. Kumar, B. Zhang, F.R. McCrate, S. Ryan, M. MacIntyre, N. Saint-Jacques, D.E. Nishri, C.A. McClure, K.A. Vriends, S. Kozie, H. Stuart-Panko, T. Freeman, J.T. George, J.T. Brockhouse, D.K. O'Brien, A. Holt, L. Almon, S. Kwong, C. Morris, R. Rycroft, L. Mueller, C.E. Phillips, H. Brown, B. Cromartie, A.G. Schwartz, F. Vigneau, G.M. Levin, B. Wohler, R. Bayakly, K.C. Ward, S.L. Gomez, M. McKinley, R. Cress, M.D. Green, K. Miyagi, L.P. Ruppert, C.F. Lynch, B. Huang, T.C. Tucker, D. Deapen, L. Liu, M.C. Hsieh, X.C. Wu, M. Schwenn, S.T. Gershman, R.C. Knowlton, G. Alverson, G.E. Copeland, S. Bushhouse, D.B. Rogers, J. Jackson-Thompson, D. Lemons, H.J. Zimmerman, M. Hood, J. Roberts-Johnson, J.R. Rees, B. Riddle, K.S. Pawlish, A. Stroup, C. Key, C. Wiggins, A.R. Kahn, M.J. Schymura, S. Radhakrishnan, C. Rao, L.K. Giljahn, R.M. Slocumb, R.E. Espinoza, F. Khan, K.G. Aird, T. Beran, J.J. Rubertone, S.J. Slack, L. Garcia, D.L. Rousseau, T.A. Janes, S.M. Schwartz, S.W. Bolick, D.M. Hurley, M.A. Whiteside, P. Miller-Gianturco, M.A. Williams, K. Herget, C. Sweeney, A.T. Johnson, M.B. Keitheri Cheteri, P. Migliore Santiago, S.E. Blankenship, S. Farley, R. Borchers, R. Malicki, J.R. Espinoza, J. Grandpre, R. Wilson, B.K. Edwards, A. Mariotto, Y. Lei, N. Wang, J.S. Chen, Y. Zhou, Y.T. He, G.H. Song, X.P. Gu, D. Mei, H.J. Mu, H.M. Ge, T.H. Wu, Y.Y. Li, D.L. Zhao, F. Jin, J.H. Zhang, F.D. Zhu, Q. Junhua, Y.L. Yang, C.X. Jiang, W. Biao, J. Wang, Q.L. Li, H. Yi, X. Zhou, J. Dong, W. Li, F.X. Fu, S.Z. Liu, J.G. Chen, J. Zhu, Y.H. Li, Y.Q. Lu, M. Fan, S.Q. Huang, G.P. Guo, H. Zhaolai, K. Wei, H. Zeng, A.V. Demetriou, W.K. Mang, K.C. Ngan, A.C. Kataki, M. Krishnatreya, P.A. Jayalekshmi, P. Sebastian, A. Nandakumar, R. Malekzadeh, G. Roshandel, L. Keinan-Boker, B.G. Silverman, H. Ito, H. Nakagawa, M. Sato, F. Tobori, I. Nakata, N. Teramoto, M. Hattori, Y. Kaizaki, F. Moki, H. Sugiyama, M. Utada, M. Nishimura, K. Yoshida, K. Kurosawa, Y. Nemoto, H. Narimatsu, M. Sakaguchi, S. Kanemura, M. Naito, R. Narisawa, I. Miyashiro, K. Nakata, S. Sato, M. Yoshii, I. Oki, N. Fukushima, A. Shibata, K. Iwasa, C. Ono, O. Nimri, K.W. Jung, Y.J. Won, E. Alawadhi, A. Elbasmi, A. Ab Manan, F. Adam, E. Sanjaajmats, U. Tudev, C. Ochir, A.M. Al Khater, M.M. El Mistiri, Y.Y. Teo, C.J. Chiang, W.C. Lee, R. Buasom, S. Sangrajrang, S. Kamsa-ard, S. Wiangnon, K. Daoprasert, D. Pongnikorn, A. Leklob, S. Sangkitipaiboon, S.L. Geater, H. Sriplung, O. Ceylan, I. Kög, O. Dirican, T. Köse, T. Gurbuz, F.E. Karaşahin, D. Turhan, U. Aktaş, Y. Halat, C.I. Yakut, M. Altinisik, Y. Cavusoglu, A. Türkköylü, N. Üçüncü, M. Hackl, A.A. Zborovskaya, O.V. Aleinikova, K. Henau, L. Van Eycken, Z. Valerianova, M.R. Yordanova, M. Šekerija, L. Dušek, M. Zvolský, H. Storm, K. Innos, M. Mägi, N. Malila, K. Seppä, J. Jégu, M. Velten, E. Cornet, X. Troussard, A.M. Bouvier, A.V. Guizard, V. Bouvier, G. Launoy, P. Arveux, M. Maynadié, M. Mounier, A.S. Woronoff, M. Daoulas, M. Robaszkiewicz, J. Clavel, S. Goujon, B. Lacour, I. Baldi, C. Pouchieu, B. Amadeo, G. Coureau, S. Orazio, P.M. Preux, F. Rharbaoui, E. Marrer, B. Trétarre, M. Colonna, P. Delafosse, K. Ligier, S. Plouvier, A. Cowppli-Bony, F. Molinié, S. Bara, O. Ganry, B. Lapôtre-Ledoux, P. Grosclaude, N. Bossard, Z. Uhry, F. Bray, M. Piñeros, R. Stabenow, H. Wilsdorf-Köhler, A. Eberle, S. Luttmann, I. Löhden, A.L. Nennecke, J. Kieschke, E. Sirri, K. Emrich, S.R. Zeissig, B. Holleczek, N. Eisemann, A. Katalinic, R.A. Asquez, V. Kumar, E. Petridou, E.J. Ólafsdóttir, L. Tryggvadóttir, K. Clough-Gorr, P.M. Walsh, H. Sundseth, G. Mazzoleni, F. Vittadello, E. Coviello, F. Cuccaro, R. Galasso, G. Sampietro, A. Giacomin, M. Magoni, A. Ardizzone, A. D'Argenzio, M. Castaing, G. Grosso, A.M. Lavecchia, A. Sutera Sardo, G. Gola, L. Gatti, P. Ricci, S. Ferretti, D. Serraino, A. Zucchetto, M.V. Celesia, R.A. Filiberti, F. Pannozzo, A. Melcarne, F. Quarta, A.G. Russo, G. Carrozzi, C. Cirilli, L. Cavalieri d'Oro, M. Rognoni, M. Fusco, M.F. Vitale, M. Usala, R. Cusimano, W. Mazzucco, M. Michiara, P. Sgargi, L. Boschetti, E. Borciani, P. Seghini, M.M. Maule, F. Merletti, R. Tumino, P. Mancuso, M. Vicentini, T. Cassetti, R. Sassatelli, F. Falcini, S. Giorgetti, A.L. Caiazzo, R. Cavallo, R. Cesaraccio, D.R. Pirino, M.L. Contrino, F. Tisano, A.C. Fanetti, S. Maspero, S. Carone, A. Mincuzzi, G. Candela, T. Scuderi, M.A. Gentilini, S. Piffer, S. Rosso, A. Barchielli, A. Caldarella, F. Bianconi, F. Stracci, P. Contiero, G. Tagliabue, M. Rugge, M. Zorzi, S. Beggiato, A. Brustolin, F. Berrino, G. Gatta, M. Sant, C. Buzzoni, L. Mangone, R. Capocaccia, R. De Angelis, R. Zanetti, A. Maurina, S. Pildava, N. Lipunova, I. Vincerževskiené, D. Agius, N. Calleja, S. Siesling, S. Larønningen, B. Møller, A. Dyzmann-Sroka, M. Trojanowski, S. Góźdź, R. Mężyk, T. Mierzwa, L. Molong, J. Rachtan, S. Szewczyk, J. Błaszczyk, K. Kępska, B. Kościańska, K. Tarocińska, M. Zwierko, K. Drosik, K.M. Maksimowicz, E. Purwin-Porowska, E. Reca, J. Wójcik-Tomaszewska, A. Tukiendorf, M. Grądalska-Lampart, A.U. Radziszewska, A. Gos, M. Talerczyk, M. Wyborska, J.A. Didkowska, U. Wojciechowska, M. Bielska-Lasota, G. Forjaz de Lacerda, R.A. Rego, J. Bastos, M.A. Silva, L. Antunes, J. Laranja Pontes, A. Mayer-da-Silva, A. Miranda, L.M. Blaga, D. Coza, L. Gusenkova, O. Lazarevich, O. Prudnikova, D.M. Vjushkov, A.G. Egorova, A.E. Orlov, L.A. Kudyakov, L.V. Pikalova, J. Adamcik, C. Safaei Diba, M. Primic-Žakelj, V. Zadnik, N. Larrañaga, A. Lopez de Munain, A.A. Herrera, R. Redondas, R. Marcos-Gragera, M.L. Vilardell Gil, E. Molina, M.J. Sánchez Perez, P. Franch Sureda, M. Ramos Montserrat, M.D. Chirlaque, C. Navarro, E.E. Ardanaz, M.M. Guevara, R. Fernández-Delgado, R. Peris-Bonet, M. Carulla, J. Galceran, C. Alberich, M. Vicente-Raneda, S. Khan, D. Pettersson, P. Dickman, I. Avelina, K. Staehelin, B. Camey, C. Bouchardy, R. Schaffar, H. Frick, C. Herrmann, J.L. Bulliard, M. Maspoli-Conconi, C.E. Kuehni, S.M. Redmond, A. Bordoni, L. Ortelli, A. Chiolero, I. Konzelmann, K.L. Matthes, S. Rohrmann, J. Broggio, J. Rashbass, D. Fitzpatrick, A. Gavin, D.I. Clark, A.J. Deas, D.W. Huws, C. White, L. Montel, B. Rachet, A.D. Turculet, R. Stephens, E. Chalker, H. Phung, R. Walton, H. You, S. Guthridge, F. Johnson, P. Gordon, K. D'Onise, K. Priest, B.C. Stokes, A. Venn, H. Farrugia, V. Thursfield, J. Dowling, D. Currow, J. Hendrix and C. Lewis, Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries, The Lancet 391, 1023–1075 (2018)

Y. Xiao, S. Liu, J. Li, W. Dai, W. Tang, L. Xiang, W. Zhang, J. Lin, J. Wang, X. Wu, G. Liu, Y. Liu, Y. Chen, H. Zhu, Y. Wang, Z. Lin, Q. Yang, T. Chen, Y. Sun, A. Li, J. Xiong, J. Wang, The POU2F1/miR-4490/USP22 axis regulates cell proliferation and metastasis in gastric cancer. Cell Oncol 43, 1017–1033 (2020)

Article  CAS  Google Scholar 

Z. Song, Y. Wu, J. Yang, D. Yang, X. Fang, Progress in the treatment of advanced gastric cancer. Tumour Biol 39, 1–7 (2017)

Article  CAS  Google Scholar 

Y. Kodera, K. Fujitani, N. Fukushima, S. Ito, K. Muro, N. Ohashi, T. Yoshikawa, D. Kobayashi, C. Tanaka, M. Fujiwara, Surgical resection of hepatic metastasis from gastric cancer: a review and new recommendation in the Japanese gastric cancer treatment guidelines. Gastric Cancer 17, 206–212 (2014)

Article  PubMed  Google Scholar 

A. Japanese Gastric Cancer, Japanese gastric cancer treatment guidelines 2018 (5th edition), Gastric Cancer 24, 1–21 (2021)

M. Donadon, G. Torzilli, N. Cortese, C. Soldani, L. Di Tommaso, B. Franceschini, R. Carriero, M. Barbagallo, A. Rigamonti, A. Anselmo, F.S. Colombo, G. Maggi, A. Lleo, J. Cibella, C. Peano, P. Kunderfranco, M. Roncalli, A. Mantovani, F. Marchesi, Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis. J Exp Med 217, 1–12 (2020)

Article  Google Scholar 

K.R. Hess, G.R. Varadhachary, S.H. Taylor, W. Wei, M.N. Raber, R. Lenzi, J.L. Abbruzzese, Metastatic patterns in adenocarcinoma. Cancer 106, 1624–1633 (2006)

Article  PubMed  Google Scholar 

P. Brodt, Role of the microenvironment in liver metastasis: From pre- to prometastatic niches. Clin Cancer Res 22, 5971–5982 (2016)

Article  CAS  PubMed  Google Scholar 

L.G. Lima, S. Ham, H. Shin, E.P.Z. Chai, E.S.H. Lek, R.J. Lobb, A.F. Muller, S. Mathivanan, B. Yeo, Y. Choi, B.S. Parker, A. Moller, Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution. Nat Commun 12, 1–12 (2021)

Article  Google Scholar 

G. Valcz, E.I. Buzas, A. Sebestyen, T. Krenacs, Z. Szallasi, P. Igaz, B. Molnar, Extracellular associated fibroblasts in anti-cancer therapy. Cancers (Basel) 12, 1–16 (2020)

Google Scholar 

X. Li, W. Yao, Y. Yuan, P. Chen, B. Li, J. Li, R. Chu, H. Song, D. Xie, X. Jiang, H. Wang, Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma. Gut 66, 157–167 (2017)

Article  CAS  PubMed  Google Scholar 

O.W. Yeung, C.M. Lo, C.C. Ling, X. Qi, W. Geng, C.X. Li, K.T. Ng, S.J. Forbes, X.Y. Guan, R.T. Poon, S.T. Fan, K. Man, Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma. J Hepatol 62, 607–616 (2015)

Article  CAS  PubMed  Google Scholar 

Z. Liu, X. Cheng, L. Zhang, J. Zhou, D. Deng, J. Ji, A panel of DNA methylated markers predicts metastasis of pN0M0 gastric carcinoma: a prospective cohort study. Brit J Cancer 121, 529–536 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.S. Airaksinen, M. Saarma, The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3, 383–394 (2002)

Article  CAS  PubMed  Google Scholar 

J. Anders, S. Kjar, C.F. Ibanez, Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site. J Biol Chem 276, 35808–35817 (2001)

Article  CAS  PubMed  Google Scholar 

M. Paolillo, S. Schinelli, Extracellular matrix alterations in metastatic processes. Int J Mol Sci 20, 1–18 (2019)

Article  Google Scholar 

B. Ni, Q. Li, C. Zhuang, P.Q. Huang, X. Xia, L.X. Yang, X.L. Ma, C. Huang, W.Y. Zhao, L. Tu, Y.Y. Shen, C.C. Zhu, Z.Z. Zhang, E.H. Zhao, M. Wang, H. Cao, The nerve-tumour regulatory axis GDNF-GFRA1 promotes tumour dormancy, imatinib resistance and local recurrence of gastrointestinal stromal tumours by achieving autophagic flux. Cancer Lett 535, 1–14 (2022)

Article  Google Scholar 

F. Castro-Giner, N. Aceto, Tracking cancer progression: from circulating tumor cells to metastasis. Genome Medicine 12, 1–12 (2020)

Article  Google Scholar 

H. Peinado, H. Zhang, I.R. Matei, B. Costa-Silva, A. Hoshino, G. Rodrigues, B. Psaila, R.N. Kaplan, J.F. Bromberg, Y. Kang, M.J. Bissell, T.R. Cox, A.J. Giaccia, J.T. Erler, S. Hiratsuka, C.M. Ghajar, D. Lyden, Pre-metastatic niches: organ-specific homes for metastases. Nature Rev Cancer 17, 302–317 (2017)

Article  CAS  Google Scholar 

Q. Li, C.C. Zhu, B. Ni, Z.Z. Zhang, S.H. Jiang, L.P. Hu, X. Wang, X.X. Zhang, P.Q. Huang, Q. Yang, J. Li, J.R. Gu, J. Xu, K.Q. Luo, G. Zhao, Z.G. Zhang, Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts. EBioMedicine 49, 157–171 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

T. Marsh, B. Tolani, J. Debnath, The pleiotropic functions of autophagy in metastasis. J Cell Sci 134, 1–15 (2021)

Article  Google Scholar 

M. Riihimaki, A. Hemminki, K. Sundquist, J. Sundquist, K. Hemminki, Metastatic spread in patients with gastric cancer. Oncotarget 7, 52307–52316 (2016)

Article  PubMed  PubMed Central  Google Scholar 

Y. Dittmar, A. Altendorf-Hofmann, F. Rauchfuss, M. Gotz, H. Scheuerlein, K. Jandt, U. Settmacher, Resection of liver metastases is beneficial in patients with gastric cancer: report on 15 cases and review of literature. Gastric Cancer 15, 131–136 (2012)

Article  PubMed  Google Scholar 

G.C. Fielder, T.W.-S. Yang, M. Razdan, Y. Li, J. Lu, J.K. Perry, P.E. Lobie, D.-X. Liu, The GDNF family: A role in cancer? Neoplasia 20, 99–117 (2018)

Article  CAS  PubMed  Google Scholar 

K. Kawai, M. Takahashi, Intracellular RET signaling pathways activated by GDNF. Cell Tissue Res. 382, 113–123 (2020)

Article  CAS  PubMed  Google Scholar 

S.-M. Huang, T.-S. Chen, C.-M. Chiu, L.-K. Chang, K.-F. Liao, H.-M. Tan, W.-L. Yeh, G.R.-L. Chang, M.-Y. Wang, D.-Y. Lu, GDNF increases cell motility in human colon cancer through VEGF–VEGFR1 interaction. Endocr. Relat. Cancer 21, 73–84 (2014)

Article  CAS  PubMed  Google Scholar 

Y.-D. Choi, J.-Y. Jung, M. Baek, S. Khan, P.I. Song, S. Ryu, J.-Y. Koo, S.C. Chauhan, A. Tsin, C. Choi, W.J. Kim, M. Kim, APE1 promotes pancreatic cancer proliferation through GFRα1/Src/ERK axis-cascade signaling in response to GDNF. Int J Mol Sci 21, 1–15 (2020)

Google Scholar 

W. Li, X. Zhang, F. Wu, Y. Zhou, Z. Bao, H. Li, P. Zheng, S. Zhao, Gastric cancer-derived mesenchymal stromal cells trigger M2 macrophage polarization that promotes metastasis and EMT in gastric cancer. Cell Death Dis 10, 918 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.T. George, H. Levine, Implications of tumor–immune coevolution on cancer evasion and optimized immunotherapy. Trends in Cancer 7, 373–383 (2021)

Article  CAS  PubMed  Google Scholar 

M.R. Junttila, F.J. de Sauvage, Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501, 346–354 (2013)

Article  CAS  PubMed  Google Scholar 

L. Wan, K. Pantel, Y. Kang, Tumor metastasis: moving new biological insights into the clinic. Nat. Med. 19, 1450–1464 (2013)

Article  CAS  PubMed  Google Scholar 

J. Majidpoor, K. Mortezaee, Steps in metastasis: an updated review. Med Oncol 38, 1–17 (2021)

Article  Google Scholar 

H. Funahashi, Y. Okada, H. Sawai, H. Takahashi, Y. Matsuo, H. Takeyama, T. Manabe, The role of glial cell line-derived neurotrophic factor (GDNF) and integrins for invasion and metastasis in human pancreatic cancer cells. J. Surg. Oncol. 91, 77–83 (2005)

Article  CAS  PubMed  Google Scholar 

L.M. Mulligan, GDNF and the RET receptor in cancer: New insights and therapeutic potential. Front. Physiol. 9, 1–13 (2019)

Article  CAS  Google Scholar 

J. Zhang, D. Rao, H. Ma, D. Kong, X. Xu, H. Lu, LncRNA SNHG15 contributes to doxorubicin resistance of osteosarcoma cells through targeting the miR-381-3p/GFRA1 axis. Open Life Sci 15, 871–883 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Bellaïche, A.-S. Goupil, E. Sambroni, J.-J. Lareyre, F. Le Gac, Gdnf-Gfra1 pathway is expressed in a spermatogenetic-dependent manner and is regulated by Fsh in a Fish testis1. Biol. Reprod. 91, 1–12 (2014)

Article 

留言 (0)

沒有登入
gif