Gerdes J, Schwab U, Lemke H, Stein H (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31:13-20.

Article  CAS  PubMed  Google Scholar 

Kreipe H, Heidebrecht HJ, Hansen S, Rohlk W, Kubbies M, Wacker HH, Tiemann M, Radzun HJ, Parwaresch R (1993) A new proliferation-associated nuclear antigen detectable in paraffin-embedded tissues by the monoclonal antibody Ki-S1. Am J Pathol 142:3-9.

CAS  PubMed  PubMed Central  Google Scholar 

La Rosa S, Sessa F, Capella C, Riva C, Leone BE, Klersy C, Rindi G, Solcia E (1996) Prognostic criteria in nonfunctioning pancreatic endocrine tumours. Virchows Arch 429:323-333.

Article  PubMed  Google Scholar 

Pelosi G, Bresaola E, Bogina G, Pasini F, Rodella S, Castelli P, Iacono C, Serio G, Zamboni G (1996) Endocrine tumors of the pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy: a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables. Hum Pathol 27:1124-1134.

Article  CAS  PubMed  Google Scholar 

Asa SL, Mete O, Cusimano MD, McCutcheon IE, et al (2021) Pituitary neuroendocrine tumors: a model for neuroendocrine tumor classification. Mod Pathol 34:1634-1650.

Article  PubMed  Google Scholar 

WHO Classification of Tumours Editorial Board (2022) Endocrine and Neuroendocrine tumours. WHO classification of tumours series, 5th ed.; vol. 8. International Agency for Research on Cancer, Lyon

Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, Bosman FT, Brambilla E, Busam KJ, de Krijger RR, Dietel M, El-Naggar AK, Fernandez-Cuesta L, Klöppel G, McCluggage WG, Moch H, Ohgaki H, Rakha EA, Reed NS, Rous BA, Sasano H, Scarpa A, Scoazec JY, Travis WD, Tallini G, Trouillas J, van Krieken JH, Cree IA (2018) A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol 31:1770-1786.

Article  PubMed  PubMed Central  Google Scholar 

Salehi F, Agur A, Scheithauer BW, Kovacs K, Lloyd RV, Cusimano M (2009) Ki-67 in pituitary neoplasms: a review--part I. Neurosurgery 65:429-437.

Article  PubMed  Google Scholar 

Grimm F, Maurus R, Beschorner R, Naros G, Stanojevic M, Gugel I, Giese S, Bier G, Bender B, Honegger J (2019) Ki-67 labeling index and expression of p53 are non-predictive for invasiveness and tumor size in functional and nonfunctional pituitary adenomas. Acta Neurochir (Wien) 161:1149-1156.

Article  PubMed  Google Scholar 

Trouillas J, Roy P, Sturm N, et al (2013) A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up. Acta Neuropathol 126:123-135.

Article  PubMed  Google Scholar 

Mete O, Cintosun A, Pressman I, Asa SL (2018) Epidemiology and biomarker profile of pituitary adenohypophysial tumors. Mod Pathol 31: 900-909.

Article  CAS  PubMed  Google Scholar 

Almeida JP, Stephens CC, Eschbacher JM, Felicella MM, Yuen KCJ, White WL, Mooney MA, Bernat AL, Mete O, Zadeh G, Gentili F, Little AS (2019) Clinical, pathologic, and imaging characteristics of pituitary null cell adenomas as defined according to the 2017 World Health Organization criteria: a case series from two pituitary centers. Pituitary 22: 514-519.

Article  CAS  PubMed  Google Scholar 

Balogun JA, Monsalves E, Juraschka K, Parvez K, Kucharczyk W, Mete O, Gentili F, Zadeh G (2015) Null cell adenomas of the pituitary gland: an institutional review of their clinical imaging and behavioral characteristics. Endocr Pathol 26: 63-70.

Article  PubMed  Google Scholar 

Alahmadi H, Lee D, Wilson JR, Hayhurst C, Mete O, Gentili F, Asa SL, Zadeh G (2012) Clinical features of silent corticotroph adenomas. Acta Neurochir (Wien) 154: 1493-1498

Article  PubMed  Google Scholar 

Guaraldi F, Zoli M, Righi A, Gibertoni D, Marino Picciola V, Faustini-Fustini M, Morandi L, Bacci A, Pasquini E, Mazzatenta D, Asioli S (2020) A practical algorithm to predict postsurgical recurrence and progression of pituitary neuroendocrine tumours (PitNET)s. Clin Endocrinol (Oxf) 93:36-43.

Article  CAS  PubMed  Google Scholar 

Asa SL, Mete O, Perry A, Osamura RY (2022) Overview of the 2022 WHO classification of pituitary tumors. Endocr Pathol 33:6-26.

Article  CAS  PubMed  Google Scholar 

Vanoli A, La Rosa S, Miceli E, Klersy C, Maragliano R, Capuano F, Persichella A, Martino M, Inzani F, Luinetti O, Di Sabatino A, Sessa F, Paulli M, Corazza GR, Rindi G, Bordi C, Capella C, Solcia E (2018) Prognostic evaluations tailored to specific gastric neuroendocrine neoplasms: Analysis of 200 cases with extended follow-up Neuroendocrinology 107:114–126.

WHO Classification of Tumours Editorial Board (2022). Head and neck tumours. WHO classification of tumours series, 5th ed.; vol. 9. International Agency for Research on Cancer, Lyon.

El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (2017) WHO Classification of Head and Neck Tumours, 4th Edition. International Agency for Research on Cancer, Lyon.

Kao HL, Chang WC, Li WY, Chia-Heng Li A, Fen-Yau Li A (2012) Head and neck large cell neuroendocrine carcinoma should be separated from atypical carcinoid on the basis of different clinical features, overall survival, and pathogenesis. Am J Surg Pathol 36:185-192.

Article  PubMed  Google Scholar 

Shah K, Perez-Ordóñez B (2016) Neuroendocrine neoplasms of the sinonasal tract: neuroendocrine carcinomas and olfactory neuroblastoma. Head Neck Pathol 10:85-94.

Article  PubMed  PubMed Central  Google Scholar 

Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A (2022) Neuroendocrine neoplasms of the larynx: a clinicopathologic analysis of 27 neuroendocrine tumors and neuroendocrine carcinomas. Head Neck Pathol 16:375-387.

Article  PubMed  Google Scholar 

Turri-Zanoni M, Maragliano R, Battaglia P, Giovannardi M, Antognoni P, Lombardi D, Morassi ML, Pasquini E, Tarchini P, Asioli S, Foschini MP, Sessa F, Nicolai P, Castelnuovo P, La Rosa S (2017) The clinicopathological spectrum of olfactory neuroblastoma and sinonasal neuroendocrine neoplasms: refinements in diagnostic criteria and impact of multimodal treatments on survival. Oral Oncol 74:21-29.

Article  PubMed  Google Scholar 

Classe M, Burgess A, El Zein S, Wassef M, Herman P, Mortuaire G, Leroy X, Malouf GG, Verillaud B (2019) Evaluating the prognostic potential of the Ki67 proliferation index and tumour-infiltrating lymphocytes in olfactory neuroblastoma. Histopathology 75:853-864.

Article  PubMed  Google Scholar 

Kakudo K, Wakasa T, Ohta Y, Yane K, Ito Y, Yamashita H (2015) Prognostic classification of thyroid follicular cell tumors using Ki-67 labeling index: risk stratification of thyroid follicular cell carcinomas. Endocr J 62:1-12.

Article  PubMed  Google Scholar 

Müller-Höcker J (1999) Immunoreactivity of p53, Ki-67, and Bcl 2 in oncocytic adenomas and carcinomas of the thyroid gland. Hum Pathol 30:926-933.

Article  PubMed  Google Scholar 

Erickson LA, Jin L, Wollan PC, Thompson GB, van Heerden J, Lloyd RV (1998) Expression of p27kip1 and Ki-67 in benign and malignant thyroid tumors. Mod Pathol 11:169-174.

CAS  PubMed  Google Scholar 

Pisani T, Pantellini F, Centanni M, Vecchione A, Giovagnoli MR (2003) Immunocytochemical expression of Ki67 and laminin in Hurthle cell adenomas and carcinomas. Anticancer Res 23: 3323-3326.

CAS  PubMed  Google Scholar 

Katoh R, Bray CE, Suzuki K, Komiyama A, Hemmi A, Kawaoi A, Oyama T, Sugai T, Sasou S (1995) Growth activity in hyperplastic and neoplastic human thyroid determined by an immunohistochemical staining procedure using monoclonal antibody MIB-1. Hum Pathol 26: 136-146.

Article  Google Scholar 

Sofiadis A, Tani E, Foukakis T, Kjellman P, Skoog L, Höög A, Wallin G, Zedenius J, Larsson C (2009) Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy. Int J Oncol 35: 369-374.

CAS  PubMed  Google Scholar 

Cho Mar K, Eimoto T, Nagaya S, Tateyama H (2006) Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid. Histopathol 48: 801-807.

Article  CAS  Google Scholar 

Tan A, Etit D, Bayol U, Altinel D, Tan S (2011) Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. Ann Diagn Pathol 15:108-116.

Article  PubMed  Google Scholar 

Hellgren LS, Stenman A, Paulsson JO, Höög A, Larsson C, Zedenius J, Juhlin CC (2022) Prognostic utility of the Ki-67 labeling index in follicular thyroid tumors: a 20-year experience from a tertiary thyroid center. Endocr Pathol 33:231-242.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ito Y, Hirokawa M, Miyauchi A, Masuoka H, Yabuta T, Fukushima M, Kihara M, Higashiyama T, Kobayashi K, Miya A (2016) Prognostic impact of Ki-67 labeling index in minimally invasive follicular thyroid carcinoma. Endocr J 63:913-917.

Article  CAS  PubMed  Google Scholar 

Ito Y, Hirokawa M, Fujishima M, Masuoka H, Higashiyama T, Kihara M, Onoda N, Miya A, Miyauchi A (2021) Prognostic significance of vascular invasion and cell-proliferation activity in widely invasive follicular carcinoma of the thyroid. Endocr J 68:881-888.

Article  PubMed  Google Scholar 

Viana AOR, Gonçalves Filho J, Francisco ALN, Pinto CAL, Kowalski LP (2020) Ki-67 and CK-19 are predictors of locoregional recurrence in papillary thyroid carcinoma. Acta Otorhinolaryngol Ital 40:190-197.

Article  PubMed  PubMed Central  Google Scholar 

Tang J, Gui C, Qiu S, Wang M (2018) The clinicopathological significance of Ki67 in papillary thyroid carcinoma: a suitable indicator? World J Surg Oncol 16: 100.

Article  PubMed  PubMed Central  Google Scholar 

Matsuse M, Yabuta T, Saenko V, Hirokawa M, Nishihara E, Suzuki K, Yamashita S, Miyauchi A, Mitsutake N (2017) TERT Promoter mutations and Ki-67 labeling index as a prognostic marker of papillary thyroid carcinomas: combination of two independent factors. Sci.Rep 7:41752.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirokawa M, Matsuda K, Kudo T, Higuchi M, Suzuki A, Takada N, Nakashima M, Miyauchi A (2019) Cribriform-morular variant of papillary thyroid carcinoma shows high Ki-67 labeling indices, despite its excellent prognosis. Pathobiology 86:248-253.

Article  CAS