I Ali and R Rafique: synthesis of targets compounds, characterization of compounds and writing of the original draft. KM Khan: supervision, conceptualization, visualization, resources, project administration, investigation, funding acquisition, formal analysis, review, editing and validation of the final draft of the manuscript. S Chigurupati: biological experiments, their investigation and analysis. A Wadood and AU Rehman: in silico studies, writing and reviewing of manuscript. SA Almahmoud and SG Felemban: investigation on bioassays and methodology. U Salar: spectroscopic data analysis, troubleshooting, writing-review and editing the draft. S Hameed: data acquisition, troubleshooting and quality control. X Ji and S Perveen: supervised all the synthetic work, quality control, spectra characterization, reviewing and editing of the manuscript. All authors revised and approved the final draft and data analysis. All authors have read and agreed to the published version of the manuscript.