3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles

The properties of dry-coated paracetamol particles (fast-dissolving model drug) with carnauba wax particles as the coating agent (dissolution retardant) are investigated. Raman mapping technique is used to non-destructively examine the thickness and homogeneity of coated particles. The results show that the wax exists in two forms on the surface of the paracetamol particles, forming a porous coating layer: i) whole wax particles on the surface of paracetamol and glued together with other wax surface particles, and ii) deformed wax particles spread on the surface. Regardless of the final particle size fraction (between 100–800 μm), the coating thickness has high variability, with average thickness of 5.9 ± 4.2 μm. The ability of carnauba wax to decrease the dissolution rate of paracetamol is confirmed by dissolution of powder and tablet formulations. The dissolution is slower for larger coated particles. Tableting further reduces the dissolution rate, clearly indicating the impact of subsequent formulation processes on the final quality of the product.

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