Personal Glucose Meters Coupled with Signal Amplification Technologies for Quantitative Detection of Non-Glucose Targets: Recent Progress and Challenges in Food Safety Hazards Analysis

Journal of Pharmaceutical Analysis

Available online 16 February 2023

Journal of Pharmaceutical AnalysisAuthor links open overlay panel, , , , , , , , , Highlights•

PGM is an effective tool for detecting food hazards.

Integration of various signal amplification technologies with PGMs.

The principles of PGM-based biosensing strategies are described.

The advantages and disadvantages of PGMs for biosensing applications are discussed.

Future challenges and perspectives of PGMs in the field of food safety are addressed.

Abstract

Ensuring food safety is paramount worldwide. Developing effective detection methods to ensure food safety can be challenging owing to trace hazards, long detection time, and resource-poor sites, in addition to the matrix effects of food. Personal glucose meters (PGMs), a classic point-of-care testing device, possess unique application advantages, demonstrating promise in food safety. Currently, many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards. Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors, which is crucial for solving the challenges associated with the use of PGMs for food safety analysis. This review introduces the basic detection principle of a PGM-based sensing strategy, which consists of three key factors: target recognition, signal transduction, and signal output. Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies (nanomaterial-loaded multienzyme labeling, nucleic acid reaction, DNAzyme catalysis, responsive nanomaterial encapsulation, and others) in the field of food safety detection have been reviewed. Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed. Despite the need for complex sample preparation and the lack of standardization in the field, using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis.

Keywords

Food safety

Personal glucose meter

Signal amplification

Point-of-care testing

Detection principle

© 2023 The Author(s). Published by Elsevier B.V. on behalf of Xi’an Jiaotong University.

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