A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice

Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92(3):6–10. https://doi.org/10.1016/j.metabol.2018.09.005.

Article  CAS  PubMed  Google Scholar 

Sun K, Kusminski CM, Scherer PE. Adipose tissue remodeling and obesity. J Clin Invest. 2011;121(6):2094–101. https://doi.org/10.1172/JCI45887.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell. 2014;157(6):1339–52. https://doi.org/10.1016/j.cell.2014.05.012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Onogi Y, Wada T, Okekawa A, Matsuzawa T, Watanabe E, Ikeda K, Nakano M, Kitada M, Koya D, Tsuneki H, Sasaoka T. Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity. Sci Rep. 2020;10(1):670. https://doi.org/10.1038/s41598-019-57368-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lackey DE, Olefsky JM. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol. 2016;1:15–28. https://doi.org/10.1038/nrendo.2015.189.

Article  CAS  Google Scholar 

Ahima RS, Qi Y, Singhal NS, Jackson MB, Scherer PE. Brain adipocytokine action and metabolic regulation. Diabetes. 2006;55(Suppl 2):S145-154. https://doi.org/10.2337/db06-S018.

Article  CAS  PubMed  Google Scholar 

Crispino M, Trinchese G, Penna E, Cimmino F, Catapano A, Villano I, Perrone-Capano C, Mollica MP. Interplay between peripheral and central inflammation in obesity-promoted disorders: The impact on synaptic mitochondrial functions. Int J Mol Sci. 2020;21(17):5964. https://doi.org/10.3390/ijms21175964.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361(5):496–509. https://doi.org/10.1056/NEJMra0804595.

Article  CAS  PubMed  Google Scholar 

Boehncke WH, Schön MP. Psoriasis. Lancet. 2015;386:983–94. https://doi.org/10.1016/S0140-6736(14)61909-7.

Article  CAS  PubMed  Google Scholar 

Kunz M, Simon JC, Saalbach A. Psoriasis: obesity and fatty acids. Front Immunol. 2019;10:1807. https://doi.org/10.3389/fimmu.2019.01807.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanda N, Hoashi T, Saeki H. Nutrition and psoriasis. Int J Mol Sci. 2020;21(15):5405. https://doi.org/10.3390/ijms21155405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wan MT, Shin DB, Hubbard RA, Noe MH, Mehta NN, Gelfand JM. Psoriasis and the risk of diabetes: a prospective population-based cohort study. J Am Acad Dermatol. 2018;78(2):315-322.e1. https://doi.org/10.1016/j.jaad.2017.10.050.

Article  PubMed  Google Scholar 

Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S. Hyperglycemia is associated with psoriatic inflammation in both humans and mice. J Invest Dermatol. 2019;139(6):1329-1338.e7. https://doi.org/10.1016/j.jid.2019.01.029.

Article  CAS  PubMed  Google Scholar 

Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: Lessons from vitamin D receptor null mice. Endocr Rev. 2008;29(6):726–76. https://doi.org/10.1210/er.2008-0004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kongsbak M, Levring TB, Geisler C, von Essen MR. The vitamin D receptor and T cell function. Front Immunol. 2013;4:148. https://doi.org/10.3389/fimmu.2013.00148.

Article  PubMed  PubMed Central  Google Scholar 

Vanherwegen AS, Eelen G, Ferreira GB, Ghesquière B, Cook DP, Nikolic T, Roep B, Carmeliet P, Telang S, Mathieu C, Gysemans C. Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism. J Steroid Biochem Mol Biol. 2019;187:134–45. https://doi.org/10.1016/j.jsbmb.2018.11.011.

Article  CAS  PubMed  Google Scholar 

Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988;67(2):373–8. https://doi.org/10.1210/jcem-67-2-373.

Article  CAS  PubMed  Google Scholar 

Hambly R, Kirby B. The relevance of serum vitamin D in psoriasis: a review. Arch Dermatol Res. 2017;309(7):499–517. https://doi.org/10.1007/s00403-017-1751-2.

Article  CAS  PubMed  Google Scholar 

Binderup L, Bramm E. Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochem Pharmacol. 1988;37(5):889–95. https://doi.org/10.1016/0006-2952(88)90177-3.

Article  CAS  PubMed  Google Scholar 

Kragballe K. Calcipotriol: a new drug for topical psoriasis treatment. Pharmacol Toxicol. 1995;77(4):241–6. https://doi.org/10.1111/j.1600-0773.1995.tb01020.x.

Article  CAS  PubMed  Google Scholar 

Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007;30(4):980–6. https://doi.org/10.2337/dc07-0665.

Article  CAS  PubMed  Google Scholar 

Lips P, Eekhoff M, van Schoor N, Oosterwerff M, de Jongh R, Krul-Poel Y, Simsek S. Vitamin D and type 2 diabetes. J Steroid Biochem Mol Biol. 2017;173:280–5. https://doi.org/10.1016/j.jsbmb.2016.11.021.

Article  CAS  PubMed  Google Scholar 

Wimalawansa SJ. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. J Steroid Biochem Mol Biol. 2018;175:177–89. https://doi.org/10.1016/j.jsbmb.2016.09.017.

Article  CAS  PubMed  Google Scholar 

Sergeev IN. Vitamin D-Cellular Ca(2+) link to obesity and diabetes. J Steroid Biochem Mol Biol. 2016;164:326–30. https://doi.org/10.1016/j.jsbmb.2015.11.008.

Article  CAS  PubMed  Google Scholar 

Benetti E, Mastrocola R, Chiazza F, Nigro D, D’Antona G, Bordano V, Fantozzi R, Aragno M, Collino M, Minetto MA. Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice. PLoS ONE. 2018;13(1):e0189707. https://doi.org/10.1371/journal.pone.0189707.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sergeev IN, Song Q. High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. Mol Nutr Food Res. 2014;58(6):1342–8. https://doi.org/10.1002/mnfr.201300503.

Article  CAS  PubMed  Google Scholar 

Yonezawa R, Wada T, Matsumoto N, Morita M, Sawakawa K, Ishii Y, Sasahara M, Tsuneki H, Saito S, Sasaoka T. Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet. Am J Physiol Endocrinol Metab. 2012;303(4):E445-456. https://doi.org/10.1152/ajpendo.00638.2011.

Article  CAS  PubMed  Google Scholar 

Wada T, Ishikawa A, Watanabe E, Nakamura Y, Aruga Y, Hasegawa H, Onogi Y, Honda H, Nagai Y, Takatsu K, Ishii Y, Sasahara M, Koya D, Tsuneki H, Sasaoka T. Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance. J Endocrinol. 2017;235(3):179–91. https://doi.org/10.1530/JOE-17-0351.

Article  CAS  PubMed  Google Scholar 

Tanaka T, Wada T, Uno K, Ogihara S, Ie H, Okekawa A, Ishikawa A, Ito T, Miyazawa Y, Sameshima A, Onogi Y, Tsuneki H, Sasahara M, Nakashima A, Saito S, Sasaoka T. Oestrogen receptor α in T cells controls the T cell immune profile and glucose metabolism in mouse models of gestational diabetes mellitus. Diabetologia. 2021;64(7):1660–73. https://doi.org/10.1007/s00125-021-05447-x.

Article  CAS  PubMed  Google Scholar 

Watanabe E, Wada T, Okekawa A, Kitamura F, Komatsu G, Onogi Y, Yamamoto S, Sasahara M, Kitada M, Koya D, Tsuneki H, Sasaoka T. Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity. Angiogenesis. 2020;23(4):667–84. https://doi.org/10.1007/s10456-020-09738-6.

Article  CAS  PubMed  Google Scholar 

Wada T, Miyashita Y, Sasaki M, Aruga Y, Nakamura Y, Ishii Y, Sasahara M, Kansaki K, Kitada M, Koya D, Shimano D, Tsuneki H, Sasaoka T. Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet. Am J Physiol Endocrinol Metab. 2013;305(11):E1415–25. https://doi.org/10.1152/ajpendo.00419.2013.

Article  CAS  PubMed  Google Scholar 

Onogi Y, Wada T, Kamiya C, Inata K, Matsuzawa T, Inaba Y, Kimura K, Inoue H, Yamamoto S, Ishii Y, Koya D, Tsuneki H, Sasahara M, Sasaoka T. PDGFRβ regulates adipose tissue expansion and glucose metabolism via vascular remodeling in diet-induced obesity. Diabetes. 2017;66(4):1008–21. https://doi.org/10.2337/db16-0881.

Article  CAS  PubMed  Google Scholar 

Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M. Overexpression of SH2-containing inositol phosphatase 2 results

留言 (0)

沒有登入
gif